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weezerific's Price:DL [3 articles]

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	Disruption of Corticocortical Connections Ameliorates Amyloid Burden in Terminal Fields in a Transgenic Model of Abeta Amyloidosis J. Neurosci., Vol. 22, No. 22. (15 November 2002), pp. 9794-9799. by Jin G. Sheng, Donald L. Price, Vassilis E. Koliatsos posted to no-tag by weezerific on 2008-11-23 23:15:31 Abstract Copy My Attachments My Copy Abstract We demonstrated previously that amyloid precursor protein (APP) is anterogradely transported from the entorhinal cortex (ERC) to the dentate gyrus via axons of the perforant pathway. In the terminal fields of these inputs, APP undergoes proteolysis to generate C-terminal fragments containing the entire amyloid [beta] peptide (A[beta]) domain. The present study was designed to test the hypothesis that APP derived from ERC neurons is the source of the A[beta] peptide deposited in the hippocampal dentate gyrus in Alzheimer's disease (AD) and ...
	Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice. Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, No. 14. (8 April 2008), pp. 5585-5590. by A. V. Savonenko, T. Melnikova, F. M. Laird, K. A. Stewart, D. L. Price, P. C. Wong posted to alzheimer app bace by weezerific on 2008-04-08 23:03:30 along with 1 person daforerog Abstract Copy My Attachments My Copy Abstract beta-Site APP-cleaving enzyme 1 (BACE1) is required for the penultimate cleavage of the amyloid-beta precursor protein (APP) leading to the generation of amyloid-beta peptides that is central to the pathogenesis of Alzheimer's disease. In addition to its role in endoproteolysis of APP, BACE1 participates in the proteolytic processing of neuregulin 1 (NRG1) and influences the myelination of central and peripheral axons. Although NRG1 has been genetically linked to schizophrenia and NRG1(+/-) mice exhibit a number of schizophrenia-like behavioral traits, it is ...
	Axonal Transport, Amyloid Precursor Protein, Kinesin-1, and the Processing Apparatus: Revisited J. Neurosci., Vol. 25, No. 9. (2 March 2005), pp. 2386-2395. by Orly Lazarov, Gerardo A. Morfini, Edward B. Lee, et al.Mohamed H. Farah, Anita Szodorai, Scott R. Deboer, Vassilis E. Koliatsos, Stefan Kins, Virginia M. Lee, Philip C. Wong, Donald L. Price, Scott T. Brady, Sangram S. Sisodia posted to app axonal trafficking transport by weezerific on 2008-03-12 19:47:09 Abstract Copy My Attachments My Copy Abstract The sequential enzymatic actions of beta-APP cleaving enzyme 1 (BACE1), presenilins (PS), and other proteins of the gamma-secretase complex liberate beta-amyloid (Abeta) peptides from larger integral membrane proteins, termed beta-amyloid precursor proteins (APPs). Relatively little is known about the normal function(s) of APP or the neuronal compartment(s) in which APP undergoes proteolytic processing. Recent studies have been interpreted as consistent with the idea that APP serves as a kinesin-1 cargo receptor and that PS and BACE1 are associated with the APP-resident ...

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