In vivo identification of uric acid stones with dual-energy CT: diagnostic performance evaluation in patients. Export

@article{citeulike:5734877, abstract = {BACKGROUND: To prospectively investigate the in vivo diagnostic performance of dual-energy (DE) computed tomography (CT) for the differentiation between uric acid (UA)-containing and non-UA-containing urinary stones. METHODS: DE CT scans were performed in 180 patients with suspected urinary stone disease using a dual-source CT scanner in the DE mode (tube voltages 80 and 140 kV). Urinary stones were classified as UA-containing or non-UA-containing based on CT number measurements and DE software results. Sensitivity, specificity, positive predictive values (PPV), and negative predictive values (NPV) for the detection of UA-containing urinary stones were calculated using the crystallographic stone analysis as the reference standard. RESULTS: DE CT detected 110/180 patients (61\%) with urinary stone disease. In 53 patients, stones were sampled. Forty-four out of 53 stones (83\%) were non-UA-containing; and nine stones (17\%) were UA-containing. The software automatically mapped 52/53 (98\%) stones. One non-UA-containing stone (UA, 2 mm) was missed; one UA-containing stone (3 mm) was misclassified by software analysis. The sensitivity, specificity, PPV, and NPV for the detection of UA-containing stones was 89\% (8/9, 95\% CI: 52-100\%), 98\% (43/44, 95\% CI: 88-100\%), 89\% (8/9, 95\% CI: 52-100\%), and 98\% (43/44, 95\% CI: 88-100\%). CONCLUSION: Our results indicate that DE dual-source CT permits for the accurate in vivo differentiation between UA-containing and non-UA-containing urinary stones.}, author = {Stolzmann, Paul and Kozomara, Marko and Chuck, Natalie and M\"{u}ntener, Michael and Leschka, Sebastian and Scheffel, Hans and Alkadhi, Hatem}, citeulike-article-id = {5734877}, citeulike-linkout-0 = {http://dx.doi.org/10.1007/s00261-009-9569-9}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19727931}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19727931}, citeulike-linkout-3 = {http://www.springerlink.com/content/t6331h1162076jh6}, day = {2}, doi = {10.1007/s00261-009-9569-9}, issn = {1432-0509}, journal = {Abdominal imaging}, keywords = {ct, kkr, uric, zueri}, month = {September}, posted-at = {2009-10-01 09:30:50}, priority = {2}, title = {In vivo identification of uric acid stones with dual-energy CT: diagnostic performance evaluation in patients.}, url = {http://dx.doi.org/10.1007/s00261-009-9569-9}, year = {2009} }

TY - JOUR ID - citeulike:5734877 L3 - citeulike-article-id:5734877 N2 - BACKGROUND: To prospectively investigate the in vivo diagnostic performance of dual-energy (DE) computed tomography (CT) for the differentiation between uric acid (UA)-containing and non-UA-containing urinary stones. METHODS: DE CT scans were performed in 180 patients with suspected urinary stone disease using a dual-source CT scanner in the DE mode (tube voltages 80 and 140 kV). Urinary stones were classified as UA-containing or non-UA-containing based on CT number measurements and DE software results. Sensitivity, specificity, positive predictive values (PPV), and negative predictive values (NPV) for the detection of UA-containing urinary stones were calculated using the crystallographic stone analysis as the reference standard. RESULTS: DE CT detected 110/180 patients (61%) with urinary stone disease. In 53 patients, stones were sampled. Forty-four out of 53 stones (83%) were non-UA-containing; and nine stones (17%) were UA-containing. The software automatically mapped 52/53 (98%) stones. One non-UA-containing stone (UA, 2 mm) was missed; one UA-containing stone (3 mm) was misclassified by software analysis. The sensitivity, specificity, PPV, and NPV for the detection of UA-containing stones was 89% (8/9, 95% CI: 52-100%), 98% (43/44, 95% CI: 88-100%), 89% (8/9, 95% CI: 52-100%), and 98% (43/44, 95% CI: 88-100%). CONCLUSION: Our results indicate that DE dual-source CT permits for the accurate in vivo differentiation between UA-containing and non-UA-containing urinary stones. JF - Abdominal imaging SN - 1432-0509 TI - In vivo identification of uric acid stones with dual-energy CT: diagnostic performance evaluation in patients. KW - ct KW - kkr KW - uric KW - zueri AU - Stolzmann, Paul AU - Kozomara, Marko AU - Chuck, Natalie AU - Müntener, Michael AU - Leschka, Sebastian AU - Scheffel, Hans AU - Alkadhi, Hatem PY - 2009/09/02/ UR - http://dx.doi.org/10.1007/s00261-009-9569-9 ER -