Peroxiredoxins in malaria parasites: parasitologic aspects. Export

@article{citeulike:3321502, abstract = {Malaria is one of the most debilitating and life threatening diseases in tropical regions of the world. Over 500 million clinical cases occur, and 2-3 million people die of the disease each year. Because Plasmodium lacks genuine glutathione peroxidase and catalase, the two major antioxidant enzymes in the eukaryotic cell, malaria parasites are likely to utilize members of the peroxiredoxin (Prx) family as the principal enzymes to reduce peroxides, which increase in the parasite cell due to metabolism and parasitism during parasite development. In addition to its function of protecting macromolecules from H(2)O(2), Prx has also been reported to regulate H(2)O(2) as second messenger in transmission of redox signals, which mediate cell proliferation, differentiation, and apoptosis. In the malaria parasite, several lines of experimental data have suggested that the parasite uses Prxs as multifunctional molecules to adapt themselves to asexual and sexual development. In this review, we summarize the accumulated knowledge on the Prx family with respect to their functions in mammalian cells and their possible function(s) in malaria parasites.}, address = {National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, 2-13 Inada-cho, Obihiro, Hokkaido 080-8555, Japan. skawazu@obihiro.ac.jp}, author = {Kawazu, S. and Komaki-Yasuda, K. and Oku, H. and Kano, S.}, citeulike-article-id = {3321502}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.parint.2007.08.001}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17890140}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17890140}, doi = {10.1016/j.parint.2007.08.001}, issn = {1383-5769}, journal = {Parasitology international}, keywords = {parasite, peroxiredoxin}, month = {March}, number = {1}, pages = {1--7}, posted-at = {2008-09-23 13:55:48}, priority = {2}, title = {Peroxiredoxins in malaria parasites: parasitologic aspects.}, url = {http://dx.doi.org/10.1016/j.parint.2007.08.001}, volume = {57}, year = {2008} }

TY - JOUR ID - citeulike:3321502 L3 - citeulike-article-id:3321502 N2 - Malaria is one of the most debilitating and life threatening diseases in tropical regions of the world. Over 500 million clinical cases occur, and 2-3 million people die of the disease each year. Because Plasmodium lacks genuine glutathione peroxidase and catalase, the two major antioxidant enzymes in the eukaryotic cell, malaria parasites are likely to utilize members of the peroxiredoxin (Prx) family as the principal enzymes to reduce peroxides, which increase in the parasite cell due to metabolism and parasitism during parasite development. In addition to its function of protecting macromolecules from H(2)O(2), Prx has also been reported to regulate H(2)O(2) as second messenger in transmission of redox signals, which mediate cell proliferation, differentiation, and apoptosis. In the malaria parasite, several lines of experimental data have suggested that the parasite uses Prxs as multifunctional molecules to adapt themselves to asexual and sexual development. In this review, we summarize the accumulated knowledge on the Prx family with respect to their functions in mammalian cells and their possible function(s) in malaria parasites. IS - 1 JF - Parasitology international SN - 1383-5769 AD - National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, 2-13 Inada-cho, Obihiro, Hokkaido 080-8555, Japan. skawazu@obihiro.ac.jp EP - 7 TI - Peroxiredoxins in malaria parasites: parasitologic aspects. VL - 57 SP - 1 KW - parasite KW - peroxiredoxin AU - Kawazu, S AU - Komaki-Yasuda, K AU - Oku, H AU - Kano, S PY - 2008/03// UR - http://dx.doi.org/10.1016/j.parint.2007.08.001 ER -