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Lack of CpG Island Methylator Phenotype Defines a Clinical Subtype of T-Cell Acute Lymphoblastic Leukemia Associated With Good Prognosis

by: Jose Roman-Gomez, Antonio Jimenez-Velasco, Xabier Agirre, Felipe Prosper, Anabel Heiniger, Antonio Torres
Journal of Clinical Oncology, Vol. 23, No. 28. (01 October 2005), pp. 7043-7049, doi:10.1200/jco.2005.01.4944  Key: citeulike:12115150

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Abstract

Purpose To examine cancer genes undergoing epigenetic inactivation in a set of T-cell acute lymphoblastic leukemias (T-ALLs) to obtain the CpG island methylator phenotype (CIMP) in the disease and its possible correlation with clinical features and outcome of the patients.


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