Stable Introduction of a Life-Shortening Wolbachia Infection into the Mosquito Aedes aegypti Export

@article{citeulike:3842995, abstract = {Most pathogens require a relatively long period of development in their mosquito vector before they can be transmitted to a new human host; hence, only older insects are of epidemiological importance. The successful transfer of a life-shortening strain of the inherited bacterial symbiont, Wolbachia, into the major mosquito vector of dengue, Aedes aegypti, halved adult life span under laboratory conditions. The association is stable, and the Wolbachia strain is maternally inherited at high frequency. It is capable of inducing complete cytoplasmic incompatibility, which should facilitate its invasion into natural field populations and its persistence over time. Our data suggest that targeting mosquito age with inherited Wolbachia infections may be a viable strategy to reduce the transmission of pathogens such as dengue viruses. 10.1126/science.1165326}, author = {McMeniman, Conor J. and Lane, Roxanna V. and Cass, Bodil N. and Fong, Amy W. C. and Sidhu, Manpreet and Wang, Yu-Feng and O'Neill, Scott L.}, citeulike-article-id = {3842995}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1165326}, citeulike-linkout-1 = {http://www.sciencemag.org/content/323/5910/141.abstract}, citeulike-linkout-2 = {http://www.sciencemag.org/content/323/5910/141.full.pdf}, citeulike-linkout-3 = {http://www.sciencemag.org/cgi/content/abstract/323/5910/141}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/19119237}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=19119237}, day = {2}, doi = {10.1126/science.1165326}, journal = {Science}, keywords = {host-pathogen, immunology}, month = {January}, number = {5910}, pages = {141--144}, posted-at = {2009-01-28 16:53:09}, priority = {2}, title = {Stable Introduction of a Life-Shortening Wolbachia Infection into the Mosquito Aedes aegypti}, url = {http://dx.doi.org/10.1126/science.1165326}, volume = {323}, year = {2009} }

TY - JOUR ID - citeulike:3842995 L3 - citeulike-article-id:3842995 N2 - Most pathogens require a relatively long period of development in their mosquito vector before they can be transmitted to a new human host; hence, only older insects are of epidemiological importance. The successful transfer of a life-shortening strain of the inherited bacterial symbiont, Wolbachia, into the major mosquito vector of dengue, Aedes aegypti, halved adult life span under laboratory conditions. The association is stable, and the Wolbachia strain is maternally inherited at high frequency. It is capable of inducing complete cytoplasmic incompatibility, which should facilitate its invasion into natural field populations and its persistence over time. Our data suggest that targeting mosquito age with inherited Wolbachia infections may be a viable strategy to reduce the transmission of pathogens such as dengue viruses. 10.1126/science.1165326 IS - 5910 JF - Science EP - 144 TI - Stable Introduction of a Life-Shortening Wolbachia Infection into the Mosquito Aedes aegypti VL - 323 SP - 141 KW - host-pathogen KW - immunology AU - McMeniman, Conor AU - Lane, Roxanna AU - Cass, Bodil AU - Fong, Amy AU - Sidhu, Manpreet AU - Wang, Yu-Feng AU - O'Neill, Scott PY - 2009/01/02/ UR - http://dx.doi.org/10.1126/science.1165326 ER -