Representation of internal models of action in the autistic brain Export

@article{citeulike:5202250, abstract = {Children with autism spectrum disorder (ASD) have deficits in motor control, imitation and social function. Does a dysfunction in the neural basis of representing internal models of action contribute to these problems? We measured patterns of generalization as children learned to control a novel tool and found that the autistic brain built a stronger than normal association between self-generated motor commands and proprioceptive feedback; furthermore, the greater the reliance on proprioception, the greater the child's impairments in social function and imitation.}, author = {Haswell, Courtney C. and Izawa, Jun and Dowell and Mostofsky and Shadmehr, Reza}, citeulike-article-id = {5202250}, citeulike-linkout-0 = {http://www.newscientist.com/article/mg20327165.300-autism-alters-how-kids-sense-motion.html?DCMP=OTC-rss&nsref=health}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nn.2356}, comment = {From New Scientist: "HOW a new action feels is more important than how it looks for children with autism. This could be why they find imitation tough. Reza Shadmehr and colleagues at Johns Hopkins University in Baltimore, Maryland, trained children with and without autism to "catch" a virtual animal using a cursor controlled by a robotic arm. The arm resisted movement in certain directions, and the kids learned to use the required extra force. The researchers then switched off the resistance and asked the children to reach for two new targets. One required them to make the cursor move in the same direction as in the training task, while the second required the same action as the training task but produced different cursor motion. Those without autism applied compensatory force in both cases, indicating that they expected the resistance to be there. But the children with autism only applied the extra force to the second new target. Shadmehr concludes that they focus on the sensation rather than visual consequences of an action and so likened only the second new task to the training task (Nature Neuroscience, DOI: 10.1038/nn.2356)."}, day = {5}, doi = {10.1038/nn.2356}, issn = {1546-1726}, journal = {Nature Neuroscience}, keywords = {autism, brain, models, motion, sensorymotor}, month = {July}, posted-at = {2009-07-19 09:09:56}, priority = {2}, publisher = {Nature Publishing Group}, title = {Representation of internal models of action in the autistic brain}, url = {http://dx.doi.org/10.1038/nn.2356}, year = {2009} }

TY - JOUR ID - citeulike:5202250 L3 - citeulike-article-id:5202250 N2 - Children with autism spectrum disorder (ASD) have deficits in motor control, imitation and social function. Does a dysfunction in the neural basis of representing internal models of action contribute to these problems? We measured patterns of generalization as children learned to control a novel tool and found that the autistic brain built a stronger than normal association between self-generated motor commands and proprioceptive feedback; furthermore, the greater the reliance on proprioception, the greater the child's impairments in social function and imitation. JF - Nature Neuroscience SN - 1546-1726 TI - Representation of internal models of action in the autistic brain PB - Nature Publishing Group KW - autism KW - brain KW - models KW - motion KW - sensorymotor N1 - From New Scientist: "HOW a new action feels is more important than how it looks for children with autism. This could be why they find imitation tough. Reza Shadmehr and colleagues at Johns Hopkins University in Baltimore, Maryland, trained children with and without autism to "catch" a virtual animal using a cursor controlled by a robotic arm. The arm resisted movement in certain directions, and the kids learned to use the required extra force. The researchers then switched off the resistance and asked the children to reach for two new targets. One required them to make the cursor move in the same direction as in the training task, while the second required the same action as the training task but produced different cursor motion. Those without autism applied compensatory force in both cases, indicating that they expected the resistance to be there. But the children with autism only applied the extra force to the second new target. Shadmehr concludes that they focus on the sensation rather than visual consequences of an action and so likened only the second new task to the training task (Nature Neuroscience, DOI: 10.1038/nn.2356)." AU - Haswell, Courtney AU - Izawa, Jun AU - Dowell AU - Mostofsky AU - Shadmehr, Reza PY - 2009/07/05/online UR - http://dx.doi.org/10.1038/nn.2356 ER -