Infection related renal impairment: a major cause of acute allograft dysfunction.

@article{citeulike:809262, abstract = {We prospectively analyzed the impact of post-transplant infections on the renal function in 532 stable renal transplant recipients (M=340; F=192) over a period of 5 years. Their age ranged from 3-75 years (40+14 years). During the follow-up period, 52 patients expired and 64 lost on followup. We defined renal impairment (RI) as a persistent rise in serum creatinine above 20\% from baseline value. 495 episodes of RI occurred in 269 recipients. This included 180-36\% episodes of acute rejection, 53-10.7\% Cyclosporine toxicity, 236-47.7\% infection related renal impairment [IRRI] and 26-5.3\% others. The severity of renal failure is less in IRRI (100+90.2) than that of acute rejection (166+127.1), but was more than that in cyclosporine toxicity (50+42.2). Sites of infection in IRRI were urinary (33\%), respiratory (26.3\%), septicemia (15.7\%) and others (25.4\%). Episode of IRRI occurred more frequently in LURD (159-67.4\%) compared to LRD-RTR (50-21.2\%). Occurrence of IRRI is more significantly higher in patients on triple drug immunosuppression (IS) (34.3\%) than those on two drug IS (13.2\%) (P=or<0.01). Ecoli (23.1\%), Pseudomonas (11.1\%), Salmonella (8.8\%), Klebsiella (8.8\%) and Staphylococai (8.3\%) were the major organisms producing IRRI. IRRI is frequent (27.8\%) during the first six months. Present study denotes that IRRI is a major cause of acute failure in RTR.}, address = {Hamad El-Essa Organ Transplant Centre, Faculty of Medicine, Kuwait University, Kuwait.}, author = {Nampoory, M. R. and Johny, K. V. and Costandy, J. N. and Nair, M. P. and Said, T. and Homoud, H. and Al-Muzairai, I. and Samhan, M. and Al-Moussawi, M. }, citeulike-article-id = {809262}, issn = {1304-0855}, journal = {Exp Clin Transplant}, keywords = {paper, test}, month = {June}, number = {1}, pages = {60--64}, posted-at = {2006-08-21 14:39:00}, priority = {2}, title = {Infection related renal impairment: a major cause of acute allograft dysfunction.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/15859909}, volume = {1}, year = {2003} }

TY - JOUR ID - citeulike:809262 L3 - citeulike-article-id:809262 TI - Infection related renal impairment: a major cause of acute allograft dysfunction. JF - Exp Clin Transplant VL - 1 IS - 1 SP - 60 EP - 64 AD - Hamad El-Essa Organ Transplant Centre, Faculty of Medicine, Kuwait University, Kuwait. SN - 1304-0855 N2 - We prospectively analyzed the impact of post-transplant infections on the renal function in 532 stable renal transplant recipients (M=340; F=192) over a period of 5 years. Their age ranged from 3-75 years (40+14 years). During the follow-up period, 52 patients expired and 64 lost on followup. We defined renal impairment (RI) as a persistent rise in serum creatinine above 20% from baseline value. 495 episodes of RI occurred in 269 recipients. This included 180-36% episodes of acute rejection, 53-10.7% Cyclosporine toxicity, 236-47.7% infection related renal impairment [IRRI] and 26-5.3% others. The severity of renal failure is less in IRRI (100+90.2) than that of acute rejection (166+127.1), but was more than that in cyclosporine toxicity (50+42.2). Sites of infection in IRRI were urinary (33%), respiratory (26.3%), septicemia (15.7%) and others (25.4%). Episode of IRRI occurred more frequently in LURD (159-67.4%) compared to LRD-RTR (50-21.2%). Occurrence of IRRI is more significantly higher in patients on triple drug immunosuppression (IS) (34.3%) than those on two drug IS (13.2%) (P=or<0.01). Ecoli (23.1%), Pseudomonas (11.1%), Salmonella (8.8%), Klebsiella (8.8%) and Staphylococai (8.3%) were the major organisms producing IRRI. IRRI is frequent (27.8%) during the first six months. Present study denotes that IRRI is a major cause of acute failure in RTR. KW - paper KW - test AU - Nampoory, MR AU - Johny, KV AU - Costandy, JN AU - Nair, MP AU - Said, T AU - Homoud, H AU - Al-Muzairai, I AU - Samhan, M AU - Al-Moussawi, M PY - 2003/06// UR - http://view.ncbi.nlm.nih.gov/pubmed/15859909 ER -