Hypotension in preterm infants with significant patent ductus arteriosus: effects of dopamine. Export

@article{citeulike:3817973, abstract = {OBJECTIVE: To study the effects of dopamine on systemic arterial pressure (SAP) and systemic blood flow (SBF) (estimated with the superior vena cava [SVC] flow) in preterm infants with hypotension and patent ductus arteriosus (PDA). STUDY DESIGN: Clinical and echocardiographic variables were measured before and 2 hours after starting dopamine in premature infants <32 weeks gestational age with PDA and systemic hypotension. RESULTS: Seventeen premature infants were included (gestational age, 28+/-2 weeks; birth weight, 1030 +/- 400 g). A mean rate of 8 +/- 2 microg/kg/min of dopamine raised SAP from 30 +/- 3 to 41 +/- 5 mm Hg (P < .05), and the pulmonary artery pressures from 25 +/- 5 to 32 +/- 8 mm Hg (P < .05). The SVC flow increased by 30\% (from 130 +/- 40 to 170 +/- 44 mL/kg/min; P < .05). The left ventricular output and the end-diastolic and mean left pulmonary artery blood flow velocities did not change despite the increase in pulmonary artery pressure. CONCLUSION: In preterm infants with hypotension and PDA, dopamine (<10 microg/kg/min) increases the systemic blood pressure and the systemic blood flow. Our results suggest that dopamine decreases left-to-right shunting across ductus arteriosus, caused by a rise in pulmonary vascular resistances.}, author = {Bouissou, Antoine and Rakza, Thameur and Klosowski, Serge and Tourneux, Pierre and Vanderborght, Marie and Storme, Laurent}, citeulike-article-id = {3817973}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.jpeds.2008.06.014}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18675433}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18675433}, doi = {10.1016/j.jpeds.2008.06.014}, issn = {1097-6833}, journal = {The Journal of pediatrics}, keywords = {cards, chd, nicu}, month = {December}, number = {6}, pages = {790--794}, posted-at = {2008-12-22 17:38:13}, priority = {2}, title = {Hypotension in preterm infants with significant patent ductus arteriosus: effects of dopamine.}, url = {http://dx.doi.org/10.1016/j.jpeds.2008.06.014}, volume = {153}, year = {2008} }

TY - JOUR ID - citeulike:3817973 L3 - citeulike-article-id:3817973 N2 - OBJECTIVE: To study the effects of dopamine on systemic arterial pressure (SAP) and systemic blood flow (SBF) (estimated with the superior vena cava [SVC] flow) in preterm infants with hypotension and patent ductus arteriosus (PDA). STUDY DESIGN: Clinical and echocardiographic variables were measured before and 2 hours after starting dopamine in premature infants <32 weeks gestational age with PDA and systemic hypotension. RESULTS: Seventeen premature infants were included (gestational age, 28+/-2 weeks; birth weight, 1030 +/- 400 g). A mean rate of 8 +/- 2 microg/kg/min of dopamine raised SAP from 30 +/- 3 to 41 +/- 5 mm Hg (P < .05), and the pulmonary artery pressures from 25 +/- 5 to 32 +/- 8 mm Hg (P < .05). The SVC flow increased by 30% (from 130 +/- 40 to 170 +/- 44 mL/kg/min; P < .05). The left ventricular output and the end-diastolic and mean left pulmonary artery blood flow velocities did not change despite the increase in pulmonary artery pressure. CONCLUSION: In preterm infants with hypotension and PDA, dopamine (<10 microg/kg/min) increases the systemic blood pressure and the systemic blood flow. Our results suggest that dopamine decreases left-to-right shunting across ductus arteriosus, caused by a rise in pulmonary vascular resistances. IS - 6 JF - The Journal of pediatrics SN - 1097-6833 EP - 794 TI - Hypotension in preterm infants with significant patent ductus arteriosus: effects of dopamine. VL - 153 SP - 790 KW - cards KW - chd KW - nicu AU - Bouissou, Antoine AU - Rakza, Thameur AU - Klosowski, Serge AU - Tourneux, Pierre AU - Vanderborght, Marie AU - Storme, Laurent PY - 2008/12// UR - http://dx.doi.org/10.1016/j.jpeds.2008.06.014 ER -