Immunologically silent cancer clone transmission from mother to offspring. Export

@article{citeulike:5952981, abstract = {Rare cases of possible materno-fetal transmission of cancer have been recorded over the past 100 years but evidence for a shared cancer clone has been very limited. We provide genetic evidence for mother to offspring transmission, in utero, of a leukemic cell clone. Maternal and infant cancer clones shared the same unique BCR-ABL1 genomic fusion sequence, indicating a shared, single-cell origin. Microsatellite markers in the infant cancer were all of maternal origin. Additionally, the infant, maternally-derived cancer cells had a major deletion on one copy of chromosome 6p that included deletion of HLA alleles that were not inherited by the infant (i.e., foreign to the infant), suggesting a possible mechanism for immune evasion.}, author = {Isoda, Takeshi and Ford, Anthony M. and Tomizawa, Daisuke and van Delft, Frederik W. and Gonzalez De Castro, David and Mitsuiki, Norkio and Score, Joannah and Taki, Tomohiko and Morio, Tomohiro and Takagi, Masatoshi and Saji, Hiroh and Greaves, Mel and Mizutani, Shuki}, citeulike-article-id = {5952981}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0904658106}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19822752}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19822752}, day = {12}, doi = {10.1073/pnas.0904658106}, issn = {1091-6490}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, keywords = {cool}, month = {October}, posted-at = {2009-10-16 21:01:18}, priority = {2}, title = {Immunologically silent cancer clone transmission from mother to offspring.}, url = {http://dx.doi.org/10.1073/pnas.0904658106}, year = {2009} }

TY - JOUR ID - citeulike:5952981 L3 - citeulike-article-id:5952981 N2 - Rare cases of possible materno-fetal transmission of cancer have been recorded over the past 100 years but evidence for a shared cancer clone has been very limited. We provide genetic evidence for mother to offspring transmission, in utero, of a leukemic cell clone. Maternal and infant cancer clones shared the same unique BCR-ABL1 genomic fusion sequence, indicating a shared, single-cell origin. Microsatellite markers in the infant cancer were all of maternal origin. Additionally, the infant, maternally-derived cancer cells had a major deletion on one copy of chromosome 6p that included deletion of HLA alleles that were not inherited by the infant (i.e., foreign to the infant), suggesting a possible mechanism for immune evasion. JF - Proceedings of the National Academy of Sciences of the United States of America SN - 1091-6490 TI - Immunologically silent cancer clone transmission from mother to offspring. KW - cool AU - Isoda, Takeshi AU - Ford, Anthony AU - Tomizawa, Daisuke AU - van Delft, Frederik AU - Gonzalez De Castro, David AU - Mitsuiki, Norkio AU - Score, Joannah AU - Taki, Tomohiko AU - Morio, Tomohiro AU - Takagi, Masatoshi AU - Saji, Hiroh AU - Greaves, Mel AU - Mizutani, Shuki PY - 2009/10/12/ UR - http://dx.doi.org/10.1073/pnas.0904658106 ER -