Amino Acid Composition of the Fetal Pig Export

@article{citeulike:2525117, abstract = {Amino acid composition and accretion were determined in fetal pigs obtained from gilts by hysterectomy at d 40-114 of gestation. The whole homogenate of the fetal pig was used for analysis of dry matter, nitrogen and amino acids. Uterine uptake of amino acids was estimated at d 110-114 of gestation on the basis of uterine arteriovenous concentrations. Nitrogen and amino acid accretion in fetal pigs increased more rapidly with gestation than non-nitrogen dry matter. Amino acid nitrogen represented 83-88\% of total nitrogen, and arginine was the most abundant nitrogen carrier in fetal pigs at all gestational ages. Amino acid composition changed with gestation, with glycine and hydroxyproline increasing (P < 0.05) markedly and other amino acids (except ornithine and tryptophan) decreasing (P < 0.05) to a lesser extent. Amino acid concentrations in fetal pigs increased (P < 0.05) progressively from d 60 to 114 of gestation. Uterine uptake of arginine and proline plus hydroxyproline met requirements for fetal growth during late gestation only marginally, and uterine uptake of aspartate/asparagine and glutamate was only 9-29\% of fetal accretion. In contrast, uterine uptake of citrulline and ornithine was 55- and 15-fold greater (P < 0.05) than fetal accretion, respectively. On the basis of hydroxyproline content, collagen was estimated to represent \~{}7, 15, 25, 28 and 29\% of total body protein at d 40, 60, 90, 110 and 114 of gestation, respectively. Amino acid composition of the fetal pig is similar to that for the human fetus, indicating that the pig is an excellent model for studying amino acid nutrition and metabolism in the human preterm neonate and infant.}, author = {Wu, Guoyao and Ott, Troy L. and Knabe, Darrell A. and Bazer, Fuller W.}, citeulike-article-id = {2525117}, citeulike-linkout-0 = {http://jn.nutrition.org/cgi/content/abstract/129/5/1031}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/10222396}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=10222396}, day = {1}, journal = {J. Nutr.}, keywords = {acid, amino, composition, fetal, pig}, month = {May}, number = {5}, pages = {1031--1038}, posted-at = {2008-03-13 10:20:56}, priority = {2}, title = {Amino Acid Composition of the Fetal Pig}, url = {http://jn.nutrition.org/cgi/content/abstract/129/5/1031}, volume = {129}, year = {1999} }

TY - JOUR ID - citeulike:2525117 L3 - citeulike-article-id:2525117 N2 - Amino acid composition and accretion were determined in fetal pigs obtained from gilts by hysterectomy at d 40-114 of gestation. The whole homogenate of the fetal pig was used for analysis of dry matter, nitrogen and amino acids. Uterine uptake of amino acids was estimated at d 110-114 of gestation on the basis of uterine arteriovenous concentrations. Nitrogen and amino acid accretion in fetal pigs increased more rapidly with gestation than non-nitrogen dry matter. Amino acid nitrogen represented 83-88% of total nitrogen, and arginine was the most abundant nitrogen carrier in fetal pigs at all gestational ages. Amino acid composition changed with gestation, with glycine and hydroxyproline increasing (P < 0.05) markedly and other amino acids (except ornithine and tryptophan) decreasing (P < 0.05) to a lesser extent. Amino acid concentrations in fetal pigs increased (P < 0.05) progressively from d 60 to 114 of gestation. Uterine uptake of arginine and proline plus hydroxyproline met requirements for fetal growth during late gestation only marginally, and uterine uptake of aspartate/asparagine and glutamate was only 9-29% of fetal accretion. In contrast, uterine uptake of citrulline and ornithine was 55- and 15-fold greater (P < 0.05) than fetal accretion, respectively. On the basis of hydroxyproline content, collagen was estimated to represent ~7, 15, 25, 28 and 29% of total body protein at d 40, 60, 90, 110 and 114 of gestation, respectively. Amino acid composition of the fetal pig is similar to that for the human fetus, indicating that the pig is an excellent model for studying amino acid nutrition and metabolism in the human preterm neonate and infant. IS - 5 JF - J. Nutr. EP - 1038 TI - Amino Acid Composition of the Fetal Pig VL - 129 SP - 1031 KW - acid KW - amino KW - composition KW - fetal KW - pig AU - Wu, Guoyao AU - Ott, Troy AU - Knabe, Darrell AU - Bazer, Fuller PY - 1999/05/01/ UR - http://jn.nutrition.org/cgi/content/abstract/129/5/1031 ER -