Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture Export

@article{citeulike:2532053, abstract = {Manipulation or non-physiological embryo culture environments can lead to defective fetal programming in livestock. Our demonstration of reduced fetal methylation and expression of ovine IGF2R suggests pre-implantation embryo procedures may be vulnerable to epigenetic alterations in imprinted genes. This highlights the potential benefits of epigenetic diagnostic screening in developing embryo procedures.}, author = {Young, Lorraine E. and Fernandes, Kenneth and McEvoy, Tom G. and Butterwith, Simon C. and Gutierrez, Carlos G. and Carolan, Catherine and Broadbent, Peter J. and Robinson, John J. and Wilmut, Ian and Sinclair, Kevin D.}, citeulike-article-id = {2532053}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/84769}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/ng0201_153}, day = {01}, doi = {10.1038/84769}, journal = {Nature Genetics}, keywords = {epigenetic, fetal, igf2r, sheep}, month = {February}, number = {2}, pages = {153--154}, posted-at = {2008-03-14 14:21:32}, priority = {2}, publisher = {Nature Publishing Group}, title = {Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture}, url = {http://dx.doi.org/10.1038/84769}, volume = {27}, year = {2001} }

TY - JOUR ID - citeulike:2532053 L3 - citeulike-article-id:2532053 N2 - Manipulation or non-physiological embryo culture environments can lead to defective fetal programming in livestock. Our demonstration of reduced fetal methylation and expression of ovine IGF2R suggests pre-implantation embryo procedures may be vulnerable to epigenetic alterations in imprinted genes. This highlights the potential benefits of epigenetic diagnostic screening in developing embryo procedures. IS - 2 JF - Nature Genetics EP - 154 TI - Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture PB - Nature Publishing Group VL - 27 SP - 153 KW - epigenetic KW - fetal KW - igf2r KW - sheep AU - Young, Lorraine AU - Fernandes, Kenneth AU - McEvoy, Tom AU - Butterwith, Simon AU - Gutierrez, Carlos AU - Carolan, Catherine AU - Broadbent, Peter AU - Robinson, John AU - Wilmut, Ian AU - Sinclair, Kevin PY - 2001/02/01/ UR - http://dx.doi.org/10.1038/84769 ER -