Host cell factors in HIV replication: meta-analysis of genome-wide studies. Export

@article{citeulike:4680650, abstract = {We have analyzed host cell genes linked to HIV replication that were identified in nine genome-wide studies, including three independent siRNA screens. Overlaps among the siRNA screens were very modest (<7\% for any pairwise combination), and similarly, only modest overlaps were seen in pairwise comparisons with other types of genome-wide studies. Combining all genes from the genome-wide studies together with genes reported in the literature to affect HIV yields 2,410 protein-coding genes, or fully 9.5\% of all human genes (though of course some of these are false positive calls). Here we report an "encyclopedia" of all overlaps between studies (available at http://www.hostpathogen.org), which yielded a more extensively corroborated set of host factors assisting HIV replication. We used these genes to calculate refined networks that specify cellular subsystems recruited by HIV to assist in replication, and present additional analysis specifying host cell genes that are attractive as potential therapeutic targets.}, author = {Bushman, Frederic D. and Malani, Nirav and Fernandes, Jason and D'Orso, Iv\'{a}n and Cagney, Gerard and Diamond, Tracy L. and Zhou, Honglin and Hazuda, Daria J. and Espeseth, Amy S. and K\"{o}nig, Renate and Bandyopadhyay, Sourav and Ideker, Trey and Goff, Stephen P. and Krogan, Nevan J. and Frankel, Alan D. and Young, John A. and Chanda, Sumit K.}, citeulike-article-id = {4680650}, citeulike-linkout-0 = {http://dx.doi.org/10.1371/journal.ppat.1000437}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19478882}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19478882}, day = {29}, doi = {10.1371/journal.ppat.1000437}, issn = {1553-7374}, journal = {PLoS pathogens}, keywords = {hiv, pathogenesis}, month = {May}, number = {5}, pages = {e1000437+}, posted-at = {2009-07-03 18:08:28}, priority = {2}, title = {Host cell factors in HIV replication: meta-analysis of genome-wide studies.}, url = {http://dx.doi.org/10.1371/journal.ppat.1000437}, volume = {5}, year = {2009} }

TY - JOUR ID - citeulike:4680650 L3 - citeulike-article-id:4680650 N2 - We have analyzed host cell genes linked to HIV replication that were identified in nine genome-wide studies, including three independent siRNA screens. Overlaps among the siRNA screens were very modest (<7% for any pairwise combination), and similarly, only modest overlaps were seen in pairwise comparisons with other types of genome-wide studies. Combining all genes from the genome-wide studies together with genes reported in the literature to affect HIV yields 2,410 protein-coding genes, or fully 9.5% of all human genes (though of course some of these are false positive calls). Here we report an "encyclopedia" of all overlaps between studies (available at http://www.hostpathogen.org), which yielded a more extensively corroborated set of host factors assisting HIV replication. We used these genes to calculate refined networks that specify cellular subsystems recruited by HIV to assist in replication, and present additional analysis specifying host cell genes that are attractive as potential therapeutic targets. IS - 5 JF - PLoS pathogens SN - 1553-7374 TI - Host cell factors in HIV replication: meta-analysis of genome-wide studies. VL - 5 SP - e1000437 KW - hiv KW - pathogenesis AU - Bushman, Frederic AU - Malani, Nirav AU - Fernandes, Jason AU - D'Orso, Iván AU - Cagney, Gerard AU - Diamond, Tracy AU - Zhou, Honglin AU - Hazuda, Daria AU - Espeseth, Amy AU - König, Renate AU - Bandyopadhyay, Sourav AU - Ideker, Trey AU - Goff, Stephen AU - Krogan, Nevan AU - Frankel, Alan AU - Young, John AU - Chanda, Sumit PY - 2009/05/29/ UR - http://dx.doi.org/10.1371/journal.ppat.1000437 ER -