Immunoglobulin light chain patterns in the cerebrospinal fluid. A study with special reference to the occurrence of free light chains in cerebrospinal fluid with and without oligoclonal immunoglobulin G. Export

@article{citeulike:2564850, abstract = {The immunoglobulin light chain patterns were studied in paired cerebrospinal fluid (CSF) and serum samples from 30 controls, 70 multiple sclerosis (MS) patients, 18 subjects with other inflammatory neurological diseases and 17 patients with other non-inflammatory neurological disorders. In MS, all CSF samples examined by two-dimensional gel electrophoresis exhibited clonally restricted light chain components. Isoelectric focusing and immunoblotting detected free light chains in around 90\% of CSF samples from patients with MS or other inflammatory diseases. These components were clonally restricted, appeared in both mono- and dimeric forms and occurred in CSF samples with as well as without oligoclonal immunoglobulin G bands. Generally, the positive CSF samples contained kappa as well as lambda free lights chains. Such components were not detected in the sera, nor in the CSF samples from controls or patients with non-inflammatory diseases.}, address = {Department of Neurology, University of Padova, Italy.}, author = {Gallo, P. and Tavolato, B. and Bergenbrant, S. and Sid\'{e}n, A.}, citeulike-article-id = {2564850}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/2515256}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=2515256}, issn = {0022-510X}, journal = {J Neurol Sci}, keywords = {csf, flc}, month = {December}, number = {1-3}, pages = {241--253}, posted-at = {2008-03-20 05:00:21}, priority = {2}, title = {Immunoglobulin light chain patterns in the cerebrospinal fluid. A study with special reference to the occurrence of free light chains in cerebrospinal fluid with and without oligoclonal immunoglobulin G.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/2515256}, volume = {94}, year = {1989} }

TY - JOUR ID - citeulike:2564850 L3 - citeulike-article-id:2564850 N2 - The immunoglobulin light chain patterns were studied in paired cerebrospinal fluid (CSF) and serum samples from 30 controls, 70 multiple sclerosis (MS) patients, 18 subjects with other inflammatory neurological diseases and 17 patients with other non-inflammatory neurological disorders. In MS, all CSF samples examined by two-dimensional gel electrophoresis exhibited clonally restricted light chain components. Isoelectric focusing and immunoblotting detected free light chains in around 90% of CSF samples from patients with MS or other inflammatory diseases. These components were clonally restricted, appeared in both mono- and dimeric forms and occurred in CSF samples with as well as without oligoclonal immunoglobulin G bands. Generally, the positive CSF samples contained kappa as well as lambda free lights chains. Such components were not detected in the sera, nor in the CSF samples from controls or patients with non-inflammatory diseases. IS - 1-3 JF - J Neurol Sci SN - 0022-510X AD - Department of Neurology, University of Padova, Italy. EP - 253 TI - Immunoglobulin light chain patterns in the cerebrospinal fluid. A study with special reference to the occurrence of free light chains in cerebrospinal fluid with and without oligoclonal immunoglobulin G. VL - 94 SP - 241 KW - csf KW - flc AU - Gallo, P AU - Tavolato, B AU - Bergenbrant, S AU - Sidén, A PY - 1989/12// UR - http://view.ncbi.nlm.nih.gov/pubmed/2515256 ER -