Free kappa and lambda light chain levels in the cerebrospinal fluid of patients with multiple sclerosis and other neurological diseases. Export

@article{citeulike:2564858, abstract = {Free kappa and lambda light chains were assayed by particle-counting immunoassay in cerebrospinal fluid (CSF) from patients with various neurological disorders. Detection limits were 25 and 50 ng/ml, respectively. Values of free kappa chain were higher than 50 ng/ml (upper reference limit) in 155 of 191 (81\%) multiple sclerosis (MS) patients, in 100 of 168 (60\%) patients with central nervous system (CNS) infections but in 41 of 217 (19\%) patients with other neurological disorders. Free kappa chains were also assayed in 273 matched sera. The mean concentration in the control group (1.58 micrograms/ml; SD: 0.41) did not differ significantly from those in MS sera (1.63 micrograms/ml; SD: 0.43). The free kappa chain index was increased in 86\% of MS patients and in 40\% of patients with CNS infections. Regarding free lambda chains, CSF values were higher than 240 ng/ml (upper reference limit) in most neurological disorders (50-100\%). However, the use of a lambda chain index increased the specificity of the assay as this index was higher than the upper reference value in 86\% of MS patients and in only 23\% of patients with infectious diseases. In MS, high levels of free kappa and lambda indices correlated significantly (P less than 0.01) with either the presence of oligoclonal bands or a high IgG index. Local synthesis of free light chains is an additional marker of an ongoing immune response within the CNS, especially in MS.}, address = {Laboratory of Neurochemistry, Universit\'{e} Catholique de Louwain, Brussels, Belgium.}, author = {Fagnart, O. C. and Sindic, C. J. and Laterre, C.}, citeulike-article-id = {2564858}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/3135296}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=3135296}, issn = {0165-5728}, journal = {J Neuroimmunol}, keywords = {csf, flc, ms}, month = {August}, number = {1-2}, pages = {119--132}, posted-at = {2008-03-20 05:08:32}, priority = {2}, title = {Free kappa and lambda light chain levels in the cerebrospinal fluid of patients with multiple sclerosis and other neurological diseases.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/3135296}, volume = {19}, year = {1988} }

TY - JOUR ID - citeulike:2564858 L3 - citeulike-article-id:2564858 N2 - Free kappa and lambda light chains were assayed by particle-counting immunoassay in cerebrospinal fluid (CSF) from patients with various neurological disorders. Detection limits were 25 and 50 ng/ml, respectively. Values of free kappa chain were higher than 50 ng/ml (upper reference limit) in 155 of 191 (81%) multiple sclerosis (MS) patients, in 100 of 168 (60%) patients with central nervous system (CNS) infections but in 41 of 217 (19%) patients with other neurological disorders. Free kappa chains were also assayed in 273 matched sera. The mean concentration in the control group (1.58 micrograms/ml; SD: 0.41) did not differ significantly from those in MS sera (1.63 micrograms/ml; SD: 0.43). The free kappa chain index was increased in 86% of MS patients and in 40% of patients with CNS infections. Regarding free lambda chains, CSF values were higher than 240 ng/ml (upper reference limit) in most neurological disorders (50-100%). However, the use of a lambda chain index increased the specificity of the assay as this index was higher than the upper reference value in 86% of MS patients and in only 23% of patients with infectious diseases. In MS, high levels of free kappa and lambda indices correlated significantly (P less than 0.01) with either the presence of oligoclonal bands or a high IgG index. Local synthesis of free light chains is an additional marker of an ongoing immune response within the CNS, especially in MS. IS - 1-2 JF - J Neuroimmunol SN - 0165-5728 AD - Laboratory of Neurochemistry, Université Catholique de Louwain, Brussels, Belgium. EP - 132 TI - Free kappa and lambda light chain levels in the cerebrospinal fluid of patients with multiple sclerosis and other neurological diseases. VL - 19 SP - 119 KW - csf KW - flc KW - ms AU - Fagnart, OC AU - Sindic, CJ AU - Laterre, C PY - 1988/08// UR - http://view.ncbi.nlm.nih.gov/pubmed/3135296 ER -