Role of natural antibodies in immune homeostasis: IVIg perspective. Export

@article{citeulike:3208188, abstract = {Intravenous immunoglobulin (IVIg) has increasingly been used for the treatment of autoimmune and systemic inflammatory diseases in addition to supportive therapy of immunodeficient patients. Although a considerable progress has been made in understanding the mechanisms by which IVIg exerts immunomodulatory functions in these diseases, they remain not fully elucidated. The mode of action of IVIg is complex, involving interference with activation of complement and the cytokine network, modulation of: idiotype network, expression of Fc receptors, and activation, differentiation and effector functions of T and B cells and of antigen-presenting cells such as dendritic cells. The therapeutic effects of IVIg most likely reflect the functions of natural antibodies in maintaining immune homeostasis in healthy individuals.}, address = {Centre de Recherche des Cordeliers, Equipe 16 - Immunopathology and Therapeutic Immunointervention, Universit\'{e} Pierre et Marie Curie - Paris 6, UMR S 872, Paris, F-75006, France.}, author = {Vani, J. and Elluru, S. and Negi, V. S. and Lacroix-Desmazes, S. and Kazatchkine, M. D. and Bayary, J. and Kaveri, S. V.}, citeulike-article-id = {3208188}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.autrev.2008.04.011}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18558359}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18558359}, doi = {10.1016/j.autrev.2008.04.011}, issn = {1568-9972}, journal = {Autoimmunity reviews}, keywords = {fc-receptors, ivig}, month = {June}, number = {6}, pages = {440--444}, posted-at = {2008-09-09 07:50:07}, priority = {2}, title = {Role of natural antibodies in immune homeostasis: IVIg perspective.}, url = {http://dx.doi.org/10.1016/j.autrev.2008.04.011}, volume = {7}, year = {2008} }

TY - JOUR ID - citeulike:3208188 L3 - citeulike-article-id:3208188 N2 - Intravenous immunoglobulin (IVIg) has increasingly been used for the treatment of autoimmune and systemic inflammatory diseases in addition to supportive therapy of immunodeficient patients. Although a considerable progress has been made in understanding the mechanisms by which IVIg exerts immunomodulatory functions in these diseases, they remain not fully elucidated. The mode of action of IVIg is complex, involving interference with activation of complement and the cytokine network, modulation of: idiotype network, expression of Fc receptors, and activation, differentiation and effector functions of T and B cells and of antigen-presenting cells such as dendritic cells. The therapeutic effects of IVIg most likely reflect the functions of natural antibodies in maintaining immune homeostasis in healthy individuals. IS - 6 JF - Autoimmunity reviews SN - 1568-9972 AD - Centre de Recherche des Cordeliers, Equipe 16 - Immunopathology and Therapeutic Immunointervention, Université Pierre et Marie Curie - Paris 6, UMR S 872, Paris, F-75006, France. EP - 444 TI - Role of natural antibodies in immune homeostasis: IVIg perspective. VL - 7 SP - 440 KW - fc-receptors KW - ivig AU - Vani, J AU - Elluru, S AU - Negi, VS AU - Lacroix-Desmazes, S AU - Kazatchkine, MD AU - Bayary, J AU - Kaveri, SV PY - 2008/06// UR - http://dx.doi.org/10.1016/j.autrev.2008.04.011 ER -