Decoding IgE Fc receptors. Export

@article{citeulike:3211162, abstract = {Immunoglobulin E (IgE) plays a central role in the pathogenesis of allergic diseases by interacting with two membrane receptors: high-affinity FcepsilonRI and low-affinity FcepsilonRII (CD23). Allergeninduced IgE-occupied FcepsilonRI aggregation on the mast cell or basophil cell surface leads to the activation of intracellular signaling events and eventually the release of pre-formed and de novo synthesized inflammatory mediators. The role of FcepsilonRII in allergic diseases has been proposed to include regulation of IgE synthesis, enhanced histamine release from basophils, and a contribution to Ag-IgE complex presentation but the exact function of CD23 remains poorly understood. This review summarizes some new developments in IgE Fc-receptor studies with an emphasis on regulation of FcepsilonRI expression and signal transduction, including monomeric IgE, lipid raft segregation, and some recently identified negative regulators. A better understanding of signaling events following IgE FcR aggregation will shed new light on how allergy patients might be treated more safely and effectively.}, address = {Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA.}, author = {Zhang, M. and Murphy, R. F. and Agrawal, D. K.}, citeulike-article-id = {3211162}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/17496343}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=17496343}, issn = {0257-277X}, journal = {Immunologic research}, keywords = {fc-receptors}, number = {1}, pages = {1--16}, posted-at = {2008-09-10 06:30:33}, priority = {2}, title = {Decoding IgE Fc receptors.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/17496343}, volume = {37}, year = {2007} }

TY - JOUR ID - citeulike:3211162 L3 - citeulike-article-id:3211162 N2 - Immunoglobulin E (IgE) plays a central role in the pathogenesis of allergic diseases by interacting with two membrane receptors: high-affinity FcepsilonRI and low-affinity FcepsilonRII (CD23). Allergeninduced IgE-occupied FcepsilonRI aggregation on the mast cell or basophil cell surface leads to the activation of intracellular signaling events and eventually the release of pre-formed and de novo synthesized inflammatory mediators. The role of FcepsilonRII in allergic diseases has been proposed to include regulation of IgE synthesis, enhanced histamine release from basophils, and a contribution to Ag-IgE complex presentation but the exact function of CD23 remains poorly understood. This review summarizes some new developments in IgE Fc-receptor studies with an emphasis on regulation of FcepsilonRI expression and signal transduction, including monomeric IgE, lipid raft segregation, and some recently identified negative regulators. A better understanding of signaling events following IgE FcR aggregation will shed new light on how allergy patients might be treated more safely and effectively. IS - 1 JF - Immunologic research SN - 0257-277X AD - Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA. EP - 16 TI - Decoding IgE Fc receptors. VL - 37 SP - 1 KW - fc-receptors AU - Zhang, M AU - Murphy, RF AU - Agrawal, DK PY - 2007/// UR - http://view.ncbi.nlm.nih.gov/pubmed/17496343 ER -