Dependence of antibody-mediated presentation of antigen on FcRn. Export

@article{citeulike:3211167, abstract = {The neonatal Fc receptor for IgG (FcRn) is a distant member of the MHC class I protein family. It binds IgG and albumin in a pH-dependent manner and protects these from catabolism by diverting them from a degradative fate in lysosomes. In addition, FcRn-mediated IgG transport across epithelial barriers is responsible for the transmission of IgG from mother to infant and can also enhance IgG-mediated antigen uptake across mucosal epithelia. We now show a previously undescribed role for FcRn in mediating the presentation of antigens by dendritic cells when antigens are present as a complex with antibody by uniquely directing multimeric immune complexes, but not monomeric IgG, to lysosomes.}, address = {Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.}, author = {Qiao, S. W. and Kobayashi, K. and Johansen, F. E. and Sollid, L. M. and Andersen, J. T. and Milford, E. and Roopenian, D. C. and Lencer, W. I. and Blumberg, R. S.}, citeulike-article-id = {3211167}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0801717105}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18599440}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18599440}, day = {8}, doi = {10.1073/pnas.0801717105}, issn = {1091-6490}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, month = {July}, number = {27}, pages = {9337--9342}, posted-at = {2008-09-10 06:41:56}, priority = {2}, title = {Dependence of antibody-mediated presentation of antigen on FcRn.}, url = {http://dx.doi.org/10.1073/pnas.0801717105}, volume = {105}, year = {2008} }

TY - JOUR ID - citeulike:3211167 L3 - citeulike-article-id:3211167 N2 - The neonatal Fc receptor for IgG (FcRn) is a distant member of the MHC class I protein family. It binds IgG and albumin in a pH-dependent manner and protects these from catabolism by diverting them from a degradative fate in lysosomes. In addition, FcRn-mediated IgG transport across epithelial barriers is responsible for the transmission of IgG from mother to infant and can also enhance IgG-mediated antigen uptake across mucosal epithelia. We now show a previously undescribed role for FcRn in mediating the presentation of antigens by dendritic cells when antigens are present as a complex with antibody by uniquely directing multimeric immune complexes, but not monomeric IgG, to lysosomes. IS - 27 JF - Proceedings of the National Academy of Sciences of the United States of America SN - 1091-6490 AD - Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. EP - 9342 TI - Dependence of antibody-mediated presentation of antigen on FcRn. VL - 105 SP - 9337 AU - Qiao, SW AU - Kobayashi, K AU - Johansen, FE AU - Sollid, LM AU - Andersen, JT AU - Milford, E AU - Roopenian, DC AU - Lencer, WI AU - Blumberg, RS PY - 2008/07/08/ UR - http://dx.doi.org/10.1073/pnas.0801717105 ER -