Arsenic detoxification and evolution of trimethylarsine gas by a microbial arsenite S-adenosylmethionine methyltransferase Export

@article{citeulike:746190, abstract = {In this article, a mechanism of arsenite [As(III)]resistance through methylation and subsequent volatization is described. Heterologous expression of arsM from Rhodopseudomonas palustris was shown to confer As(III) resistance to an arsenic-sensitive strain of Escherichia coli. ArsM catalyzes the formation of a number of methylated intermediates from As(III), with trimethylarsine as the end product. The net result is loss of arsenic, from both the medium and the cells. Because ArsM homologues are widespread in nature, this microbial-mediated transformation is proposed to have an important impact on the global arsenic cycle. 10.1073/pnas.0506836103}, author = {Qin, Jie and Rosen, Barry P. and Zhang, Yang and Wang, Gejiao and Franke, Sylvia and Rensing, Christopher}, citeulike-article-id = {746190}, citeulike-linkout-0 = {http://www.pnas.org/cgi/content/abstract/103/7/2075}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16452170}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16452170}, day = {14}, journal = {PNAS}, keywords = {overexpression, protein}, month = {February}, number = {7}, pages = {2075--2080}, posted-at = {2006-07-07 21:41:49}, priority = {2}, title = {Arsenic detoxification and evolution of trimethylarsine gas by a microbial arsenite S-adenosylmethionine methyltransferase}, url = {http://www.pnas.org/cgi/content/abstract/103/7/2075}, volume = {103}, year = {2006} }

TY - JOUR ID - citeulike:746190 L3 - citeulike-article-id:746190 N2 - In this article, a mechanism of arsenite [As(III)]resistance through methylation and subsequent volatization is described. Heterologous expression of arsM from Rhodopseudomonas palustris was shown to confer As(III) resistance to an arsenic-sensitive strain of Escherichia coli. ArsM catalyzes the formation of a number of methylated intermediates from As(III), with trimethylarsine as the end product. The net result is loss of arsenic, from both the medium and the cells. Because ArsM homologues are widespread in nature, this microbial-mediated transformation is proposed to have an important impact on the global arsenic cycle. 10.1073/pnas.0506836103 IS - 7 JF - PNAS EP - 2080 TI - Arsenic detoxification and evolution of trimethylarsine gas by a microbial arsenite S-adenosylmethionine methyltransferase VL - 103 SP - 2075 KW - overexpression KW - protein AU - Qin, Jie AU - Rosen, Barry AU - Zhang, Yang AU - Wang, Gejiao AU - Franke, Sylvia AU - Rensing, Christopher PY - 2006/02/14/ UR - http://www.pnas.org/cgi/content/abstract/103/7/2075 ER -