Role of helix 8 in G protein-coupled receptors based on structure-function studies on the type 1 angiotensin receptor. Export

@article{citeulike:4787872, abstract = {G protein-coupled receptors (GPCRs) are transmembrane receptors that convert extracellular stimuli to intracellular signals. The type 1 angiotensin II receptor is a widely studied GPCR with roles in blood pressure regulation,water and salt balance and cell growth. The complex molecular and structural changes that underpin receptor activation and signaling are the focus of intense research. Increasingly, there is an appreciation that the plasma membrane participates in receptor function via direct, physical interactions that reciprocally modulate both lipid and receptor and provide microdomains for specialized activities. Reversible protein:lipid interactions are commonly mediated by amphipathic -helices in proteins and one such motif - a short helix, referred to as helix VIII/8 (H8), located at the start of the carboxyl (C)-terminus of GPCRs - is gaining recognition for its importance to GPCR function. Here, we review the identification of H8 in GPCRs and examine its capacity to sense and interact with diverse proteins and lipid environment, most notably with acidic lipids that include phosphatidylinositol phosphates.}, author = {Huynh, J. and Thomas, W. G. and Aguilar, M. I. and Pattenden, L. K.}, citeulike-article-id = {4787872}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/19418628}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=19418628}, day = {29}, issn = {0303-7207}, journal = {Molecular and cellular endocrinology}, keywords = {activation, angiotensin, helix8, structure}, month = {April}, number = {2}, pages = {118--127}, posted-at = {2009-06-09 15:33:42}, priority = {2}, title = {Role of helix 8 in G protein-coupled receptors based on structure-function studies on the type 1 angiotensin receptor.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/19418628}, volume = {302}, year = {2009} }

TY - JOUR ID - citeulike:4787872 L3 - citeulike-article-id:4787872 N2 - G protein-coupled receptors (GPCRs) are transmembrane receptors that convert extracellular stimuli to intracellular signals. The type 1 angiotensin II receptor is a widely studied GPCR with roles in blood pressure regulation,water and salt balance and cell growth. The complex molecular and structural changes that underpin receptor activation and signaling are the focus of intense research. Increasingly, there is an appreciation that the plasma membrane participates in receptor function via direct, physical interactions that reciprocally modulate both lipid and receptor and provide microdomains for specialized activities. Reversible protein:lipid interactions are commonly mediated by amphipathic -helices in proteins and one such motif - a short helix, referred to as helix VIII/8 (H8), located at the start of the carboxyl (C)-terminus of GPCRs - is gaining recognition for its importance to GPCR function. Here, we review the identification of H8 in GPCRs and examine its capacity to sense and interact with diverse proteins and lipid environment, most notably with acidic lipids that include phosphatidylinositol phosphates. IS - 2 JF - Molecular and cellular endocrinology SN - 0303-7207 EP - 127 TI - Role of helix 8 in G protein-coupled receptors based on structure-function studies on the type 1 angiotensin receptor. VL - 302 SP - 118 KW - activation KW - angiotensin KW - helix8 KW - structure AU - Huynh, J AU - Thomas, WG AU - Aguilar, MI AU - Pattenden, LK PY - 2009/04/29/ UR - http://view.ncbi.nlm.nih.gov/pubmed/19418628 ER -