xdeupi's agonist [46 articles] Export

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	Ligand-regulated oligomerization of beta(2)-adrenoceptors in a model lipid bilayer. [My Copy] The EMBO journal (17 September 2009) by Juan José J. Fung, Xavier Deupi, Leonardo Pardo, et al.Xiao Jie J. Yao, Gisselle A. Velez-Ruiz, Brian T. Devree, Roger K. Sunahara, Brian K. Kobilka posted to oligomerization inverse_agonist fret b2ar antagonist agonist by xdeupi on 2009-10-06 19:26:56 as
	Exploring the mechanism of agonist efficacy: a relationship between efficacy and agonist dissociation rate at the muscarinic M3 receptor. [My Copy] Molecular pharmacology, Vol. 76, No. 3. (September 2009), pp. 543-551. by David A. Sykes, Mark R. Dowling, Steven J. Charlton posted to efficacy drug binding_kinetics binding agonist by xdeupi on 2009-10-06 17:50:31 as
	Hot-Spots-Guided Receptor-Based Pharmacophores (HS-Pharm): A Knowledge-Based Approach to Identify Ligand-Anchoring Atoms in Protein Cavities and Prioritize Structure-Based Pharmacophores [My Copy] Journal of Chemical Information and Modeling, Vol. 48, No. 7. (1 July 2008), pp. 1396-1410. by Caterina Barillari, Gilles Marcou, Didier Rognan posted to theory pharmacology ligands drug docking binding b2ar agonist by xdeupi on 2009-10-05 18:45:05 as along with 3 people tbinbal superpyrin higueruelo
	Allosteric modulation of muscarinic acetylcholine receptors. [My Copy] Current neuropharmacology, Vol. 5, No. 3. (September 2007), pp. 157-167. by K. J. Gregory, P. M. Sexton, A. Christopoulos posted to activation agonist binding kinetics ligands pharmacology by xdeupi on 2009-07-20 18:21:37 as
	Sequence-Derived Three-Dimensional Pharmacophore Models for G-Protein-Coupled Receptors and Their Application in Virtual Screening [My Copy] Journal of Medicinal Chemistry, Vol. 0, No. 0. (0000) by Thomas Klabunde, Clemens Giegerich, Andreas Evers posted to agonist antagonist binding drug ligands modeling pharmacology by xdeupi on 2009-05-06 09:59:59 as along with 1 person reyez
	Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors. [My Copy] Molecular pharmacology, Vol. 75, No. 4. (April 2009), pp. 982-990. by L. P. Pellissier, J. Sallander, M. Campillo, et al.F. Gaven, E. Queffeulou, M. Pillot, A. Dumuis, S. Claeysen, J. Bockaert, L. Pardo posted to activation agonist switch toggle by xdeupi on 2009-05-06 09:50:42 as along with 1 person arnaucordomi
	Fluorescent GPCR ligands as new tools in pharmacology. [My Copy] Current medicinal chemistry, Vol. 15, No. 21. (2008), pp. 2132-2143. by K. Kuder, K. Kieć-Kononowicz posted to activation agonist binding drug fluorescence imaging ligands by xdeupi on 2008-10-15 10:30:17 as
	Recruitment of beta-arrestin2 to the dopamine D2 receptor: Insights into anti-psychotic and anti-parkinsonian drug receptor signaling. [My Copy] Neuropharmacology (8 April 2008) by Ib V V. Klewe, Søren M M. Nielsen, Louise Tarpø, et al.Eneko Urizar, Concetta Dipace, Jonathan A A. Javitch, Ulrik Gether, Jan Egebjerg, Kenneth V V. Christensen posted to activation active-state agonist arrestin biased_agonism binding disease fluorescence imaging internalization pharmacology by xdeupi on 2008-05-13 16:24:49 as
	Chemogenomic approaches to rational drug design [My Copy] Br J Pharmacol, Vol. 152, No. 1. (29 May 2007), pp. 38-52. by D. Rognan posted to agonist binding drug ligands pharmacology priviledged_structures by xdeupi on 2008-03-28 15:54:47 as along with 4 people and 3 groups jmrivort jerome_ucsf_slb guhjy tjimenez LabCompMed G-quadruplex Supramolecular
	beta-Arrestin-biased Agonism at the beta2-Adrenergic Receptor. [My Copy] J Biol Chem, Vol. 283, No. 9. (29 February 2008), pp. 5669-5676. by M. T. Drake, J. D. Violin, E. J. Whalen, J. W. Wisler, S. K. Shenoy, R. J. Lefkowitz posted to activation agonist arrestin b2ar biased_agonism drug gproteins imaging internalization ligands pharmacology by xdeupi on 2008-02-27 10:39:07 as along with 1 group LabCompMed
	Chromophore Channeling in the G-Protein Coupled Receptor Rhodopsin. [My Copy] J Am Chem Soc (15 May 2007) by Ting Wang, Yong Duan posted to activation agonist amber binding ligands md modeling rhodopsin by xdeupi on 2007-05-21 10:04:04 as along with 1 group LabCompMed
	Multiple signaling states of G-protein-coupled receptors. [My Copy] Pharmacol Rev, Vol. 57, No. 2. (June 2005), pp. 147-161. by D. M. Perez, S. S. Karnik posted to activation agonist gpcr pharmacology review rhodopsin switch by xdeupi on 2007-04-26 14:57:25 as along with 1 group LabCompMed
	Role of group-conserved residues in the helical core of beta2-adrenergic receptor. [My Copy] Proc Natl Acad Sci U S A, Vol. 104, No. 17. (24 April 2007), pp. 7027-7032. by P. Chelikani, V. Hornak, M. Eilers, et al.P. J. Reeves, S. O. Smith, U. L. Rajbhandary, H. G. Khorana posted to activation agonist b2ar ser switch tm4 by xdeupi on 2007-04-26 12:27:17 as along with 1 group LabCompMed
	"Phenotypic" pharmacology: the influence of cellular environment on G protein-coupled receptor antagonist and inverse agonist pharmacology. [My Copy] Biochem Pharmacol, Vol. 73, No. 6. (15 March 2007), pp. 737-751. by C. P. Nelson, R. A. Challiss posted to agonist gpcr ligands pharmacology by xdeupi on 2007-04-10 18:54:26 as along with 1 person and 2 groups Fritz neurolit LabCompMed
	Bioluminescence resonance energy transfer as a screening assay: Focus on partial and inverse agonism. [My Copy] J Biomol Screen, Vol. 12, No. 1. (February 2007), pp. 41-49. by L. Elster, C. Elling, A. Heding posted to activation agonist b2ar fret ligands by xdeupi on 2007-04-10 18:50:15 as along with 1 group LabCompMed
	Real-time optical recording of beta1-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol. [My Copy] J Clin Invest, Vol. 117, No. 1. (January 2007), pp. 229-235. by F. Rochais, J. P. Vilardaga, V. O. Nikolaev, M. Bünemann, M. J. Lohse, S. Engelhardt posted to activation agonist b2ar helix8 mutation by xdeupi on 2007-03-12 14:39:00 as along with 1 group LabCompMed
	Subclassification and nomenclature of alpha- and beta-adrenoceptors. [My Copy] Curr Top Med Chem, Vol. 7, No. 2. (2007), pp. 129-134. by J. P. Hieble posted to agonist b2ar drug genome ligands pharmacology review by xdeupi on 2007-03-12 14:33:19 as along with 1 group LabCompMed
	Recent advances in identification and characterization of beta-adrenoceptor agonists and antagonists. [My Copy] Curr Top Med Chem, Vol. 7, No. 2. (2007), pp. 207-216. by J. P. Hieble posted to agonist b2ar drug ligands pharmacology by xdeupi on 2007-03-12 14:32:04 as along with 1 group LabCompMed
	Both Ligand- and Cell-Specific Parameters Control Ligand Agonism in a Kinetic Model of G Protein-Coupled Receptor Signaling. [My Copy] PLoS Comput Biol, Vol. 3, No. 1. (12 January 2007) by Tamara L L. Kinzer-Ursem, Jennifer J J. Linderman posted to activation agonist b2ar pharmacology by xdeupi on 2007-02-13 15:38:17 as along with 1 group LabCompMed
	Identification of an agonist-induced conformational change occurring adjacent to the ligand-binding pocket of the M(3) muscarinic acetylcholine receptor. [My Copy] J Biol Chem, Vol. 280, No. 41. (14 October 2005), pp. 34849-34858. by S. J. Han, F. F. Hamdan, S. K. Kim, et al.K. A. Jacobson, L. M. Bloodworth, B. Li, J. Wess posted to ligands cation-pi binding agonist by xdeupi on 2007-01-15 16:08:15 as along with 1 group LabCompMed
	Activation of the CXCR3 chemokine receptor through anchoring of a small molecule chelator ligand between TM-III, -IV and -VI. [My Copy] Mol Pharmacol (14 December 2006) by Mette M M. Rosenkilde, Michael B B. Andersen, Rie Nygaard, Thomas M M. Frimurer, Thue W W. Schwartz posted to ligands ionic chemokine cation-pi agonist activation by xdeupi on 2007-01-11 16:06:35 as along with 1 group LabCompMed
	GluVII:06--a highly conserved and selective anchor point for non-peptide ligands in chemokine receptors. [My Copy] Curr Top Med Chem, Vol. 6, No. 13. (2006), pp. 1319-1333. by M. M. Rosenkilde, T. W. Schwartz posted to modeling ligands ionic chemokine binding agonist by xdeupi on 2007-01-10 14:45:13 as along with 1 group LabCompMed
	dummy [My Copy] by Dummy posted to 5ht1a activation agonist amber amine arrestin b2ar bimane binding cam ccr5 channel chemokine chimera crystallography cterm cxcr1 d250 dimer disease drug dry dynamics ecl2 evolution expression fluorescence folding fret genome gly gpcr gproteins hbond helix helix8 histamine hormone icl3 imaging internalization ionic leukotriene lhr ligands lipids lock loops md membrane modeling mutation n745 n749 nmr npxxy nterm opioid pharmacology polymorphism pro-kink protonation review rhodopsin s542 sequence ser spin_labeling structure switch thr thyrotropin tm2 tm3 tm5 tm6 tm7 toggle transmembrane trp txp w648 by xdeupi on 2006-10-30 12:30:16 as along with 2 people and 1 group jessicaopacic ivanrt LabCompMed
	Novel mutants of the human beta1-adrenergic receptor reveal amino acids relevant for receptor activation. [My Copy] J Biol Chem, Vol. 281, No. 26. (30 June 2006), pp. 18120-18125. by B. Behr, C. Hoffmann, G. Ottolina, K. N. Klotz posted to activation agonist b2ar binding drug ligands modeling mutation pharmacology structure by xdeupi on 2006-09-05 11:05:20 as along with 1 group LabCompMed
	Determining the Potency and Molecular Mechanism of Action of Insurmountable Antagonists. [My Copy] J Pharmacol Exp Ther (20 July 2006) by Terry P P. Kenakin, Stephen Jenkinson, Christian Watson posted to activation drug ligands agonist pharmacology by xdeupi on 2006-09-05 09:51:58 as along with 1 group LabCompMed
	GPCR agonists and antagonists in the clinic. [My Copy] Med Chem, Vol. 1, No. 4. (July 2005), pp. 405-421. by J. D. Tyndall, R. Sandilya posted to agonist drug gpcr ligands pharmacology by xdeupi on 2006-07-24 10:18:01 as along with 1 group LabCompMed
	Data-Driven Analysis in Drug Discovery [My Copy] Journal of Receptors and Signal Transduction, Vol. 26, No. 4. (August 2006), pp. 299-327. by Terry Kenakin posted to agonist binding drug ligands pharmacology by xdeupi on 2006-07-17 16:28:05 as along with 1 group LabCompMed
	Molecular evolution of adrenoceptors and dopamine receptors: implications for the binding of catecholamines. [My Copy] J Med Chem, Vol. 49, No. 5. (9 March 2006), pp. 1706-1719. by H. Xhaard, V. V. Rantanen, T. Nyrönen, M. S. Johnson posted to agonist b2ar binding gpcr ligands modeling by xdeupi on 2006-03-06 10:11:30 as along with 1 group LabCompMed
	Molecular mechanisms of beta2-adrenergic receptor function and regulation. [My Copy] Proc Am Thorac Soc, Vol. 2, No. 4. (2005) by D. W. McGraw, S. B. Liggett posted to activation agonist b2ar by xdeupi on 2006-02-20 09:27:39 as along with 1 group LabCompMed
	Principal pathway coupling agonist binding to channel gating in nicotinic receptors [My Copy] Nature, Vol. 438, No. 7065. (10 November 2005), pp. 243-247. by Won Y. Lee, Steven M. Sine posted to activation agonist binding channel ser by xdeupi on 2006-01-27 12:32:01 as along with 1 person and 3 groups barry structural_bioinformatics Bioinformatics LabCompMed
	Functionally different agonists induce distinct conformations in the G protein coupling domain of the beta 2 adrenergic receptor. [My Copy] J Biol Chem, Vol. 276, No. 27. (6 July 2001), pp. 24433-24436. by P. Ghanouni, Z. Gryczynski, J. J. Steenhuis, et al.T. W. Lee, D. L. Farrens, J. R. Lakowicz, B. K. Kobilka posted to activation agonist b2ar by xdeupi on 2005-12-16 10:23:33 as along with 1 group LabCompMed
	Agonist-induced conformational changes in the G-protein-coupling domain of the beta 2 adrenergic receptor. [My Copy] Proc Natl Acad Sci U S A, Vol. 98, No. 11. (22 May 2001), pp. 5997-6002. by P. Ghanouni, J. J. Steenhuis, D. L. Farrens, B. K. Kobilka posted to activation agonist b2ar fluorescence by xdeupi on 2005-12-16 10:22:41 as along with 1 group LabCompMed
	Single-molecule spectroscopy of the beta(2) adrenergic receptor: observation of conformational substates in a membrane protein. [My Copy] Proc Natl Acad Sci U S A, Vol. 98, No. 15. (17 July 2001), pp. 8469-8474. by G. Peleg, P. Ghanouni, B. K. Kobilka, R. N. Zare posted to activation agonist b2ar by xdeupi on 2005-12-16 10:21:35 as along with 2 people and 2 groups quanwang yanjiang LabCompMed moernerlab
	Sequential binding of agonists to the beta2 adrenoceptor. Kinetic evidence for intermediate conformational states. [My Copy] J Biol Chem, Vol. 279, No. 1. (2 January 2004), pp. 686-691. by G. Swaminath, Y. Xiang, T. W. Lee, J. Steenhuis, C. Parnot, B. K. Kobilka posted to activation agonist b2ar binding ligands tm6 by xdeupi on 2005-12-16 10:19:18 as along with 1 person and 1 group jddowney LabCompMed
	Partial Agonism in a G Protein-coupled Receptor: ROLE OF THE RETINAL RING STRUCTURE IN RHODOPSIN ACTIVATION [My Copy] J. Biol. Chem., Vol. 280, No. 40. (7 October 2005), pp. 34259-34267. by Franz J. Bartl, Olaf Fritze, Eglof Ritter, et al.Rolf Herrmann, Vladimir Kuksa, Krzysztof Palczewski, Klaus P. Hofmann, Oliver P. Ernst posted to activation agonist rhodopsin by xdeupi on 2005-11-22 19:52:14 as along with 1 group LabCompMed
	New concepts in drug discovery: collateral efficacy and permissive antagonism. [My Copy] Nat Rev Drug Discov, Vol. 4, No. 11. (November 2005), pp. 919-927. by T. Kenakin posted to activation agonist ccr5 gpcr ligands by xdeupi on 2005-11-04 21:57:24 as along with 1 group LabCompMed
	Agonist binding: a multistep process. [My Copy] Mol Pharmacol, Vol. 65, No. 5. (May 2004), pp. 1060-1062. by B. Kobilka posted to activation agonist b2ar binding gpcr by xdeupi on 2005-11-02 22:50:37 as along with 1 group LabCompMed
	Linking agonist binding to histamine H1 receptor activation [My Copy] Nat Chem Biol, Vol. 1, No. 2. (July 2005), pp. 98-103. by Aldo Jongejan, Martijn Bruysters, Juan A. Ballesteros, et al.Eric Haaksma, Remko A. Bakker, Leonardo Pardo, Rob Leurs posted to activation agonist binding histamine n745 npxxy by xdeupi on 2005-11-01 01:19:58 as along with 1 group LabCompMed
	The forgotten serine. A critical role for Ser-2035.42 in ligand binding to and activation of the beta 2-adrenergic receptor. [My Copy] J Biol Chem, Vol. 275, No. 48. (1 December 2000), pp. 37779-37788. by G. Liapakis, J. A. Ballesteros, S. Papachristou, W. C. Chan, X. Chen, J. A. Javitch posted to activation agonist b2ar binding s542 ser tm5 by xdeupi on 2005-11-01 01:02:07 as along with 1 group LabCompMed
	The binding site of aminergic G protein-coupled receptors: the transmembrane segments and second extracellular loop. [My Copy] Annu Rev Pharmacol Toxicol, Vol. 42 (2002), pp. 437-467. by L. Shi, J. A. Javitch posted to agonist binding ecl2 gpcr helix loops transmembrane by xdeupi on 2005-11-01 01:00:19 as along with 1 person and 1 group IrinaMoreira LabCompMed
	Synergistic contributions of the functional groups of epinephrine to its affinity and efficacy at the beta2 adrenergic receptor. [My Copy] Mol Pharmacol, Vol. 65, No. 5. (May 2004), pp. 1181-1190. by G. Liapakis, W. C. Chan, M. Papadokostaki, J. A. Javitch posted to activation agonist b2ar by xdeupi on 2005-11-01 00:57:14 as along with 1 group LabCompMed
	Catechol-binding serines of beta(2)-adrenergic receptors control the equilibrium between active and inactive receptor states. [My Copy] Mol Pharmacol, Vol. 57, No. 1. (January 2000), pp. 198-210. by C. Ambrosio, P. Molinari, S. Cotecchia, T. Costa posted to activation agonist b2ar ser tm5 by xdeupi on 2005-10-31 23:56:50 as along with 1 group LabCompMed
	Mutations inducing divergent shifts of constitutive activity reveal different modes of binding among catecholamine analogues to the beta(2)-adrenergic receptor. [My Copy] Br J Pharmacol, Vol. 135, No. 7. (April 2002), pp. 1715-1722. by R. Del Carmine, C. Ambrosio, M. Sbraccia, S. Cotecchia, A. P. Ijzerman, T. Costa posted to activation agonist b2ar by xdeupi on 2005-10-31 23:55:27 as along with 1 group LabCompMed
	"Induced-fit" mechanism for catecholamine binding to the beta2-adrenergic receptor. [My Copy] Mol Pharmacol, Vol. 66, No. 2. (August 2004), pp. 356-363. by R. Del Carmine, P. Molinari, M. Sbraccia, C. Ambrosio, T. Costa posted to activation agonist b2ar by xdeupi on 2005-10-31 23:54:36 as along with 1 group LabCompMed
	Different structural requirements for the constitutive and the agonist-induced activities of the beta2-adrenergic receptor. [My Copy] J Biol Chem, Vol. 280, No. 25. (24 June 2005), pp. 23464-23474. by C. Ambrosio, P. Molinari, F. Fanelli, et al.Y. Chuman, M. Sbraccia, O. Ugur, T. Costa posted to activation agonist b2ar ser by xdeupi on 2005-10-31 23:54:01 as along with 1 group LabCompMed
	Probing the beta2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists. [My Copy] J Biol Chem, Vol. 280, No. 23. (10 June 2005), pp. 22165-22171. by G. Swaminath, X. Deupi, T. W. Lee, et al.W. Zhu, F. S. Thian, T. S. Kobilka, B. Kobilka posted to activation agonist b2ar switch toggle by xdeupi on 2005-10-25 01:25:28 as along with 1 person and 3 groups marcius BioinfoCIPF LabCompMed SGU-CIPF

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activation	171
gpcr	110
structure	89
rhodopsin	79
review	64
modeling	62
b2ar	58
dynamics	56
helix	50
transmembrane	47
agonist	46
binding	44
theory	42
ligands	41
drug	36
md	35
switch	34
membrane_proteins	31
crystallography	30
nmr	30
pharmacology	30
membrane	26
gproteins	23
dimer	20
fluorescence	18
sequence	17
ser	17
active-state	15
folding	14
fret	14
genome	14
loops	14
pro-kink	14
flexibility	13
disease	12
tm6	12
cterm	11
mutation	11
retinal	11
amber	10
evolution	10
toggle	10
docking	9
energy_landscape	9
kinetics	9
lipids	9
neurokinin	9
tm5	9
arrestin	8
chemokine	8
gpcrs	8
hbond	8
helix8	8
imaging	8
bimane	7
cancer	7
channel	7
ecl2	7
gly	7
icl3	7
ionic	7
lmc_101	7
plasticity	7
protonation	7
tm3	7
w648	7
cation-pi	6
ccr5	6
cys_scanning	6
d250	6
internalization	6
npxxy	6
opioid	6
thyrotropin	6
tm2	6
xray	6
amine	5
binding_kinetics	5
conformational_changes	5
dimerization	5
dry	5
expression	5
lock	5
polymorphism	5
spectroscopy	5
thr	5
trp	5
antagonist	4
cam	4
cholesterol	4
disorder	4
hormone	4
n749	4
nterm	4
pathway	4
tm7	4
water	4
angiotensin	3
biased_agonism	3
cxcr1	3
grk	3
histamine	3
n745	3
oligomerization	3
spin_labeling	3
toac	3
webserver	3
5ht1a	2
chimera	2
crosslinking	2
em	2
leukotriene	2
lhr	2
networks	2
pathways	2
phylogeny	2
s542	2
solvation	2
tm1	2
tmhs	2
txp	2
b1ar	1
binding_site	1
class_c	1
efficacy	1
gaba	1
induced_fit	1
inverse_agonist	1
kinase	1
kinks	1
metai	1
oligomers	1
peptide	1
priviledged_structures	1
proline	1
protein_docking	1
sequence_alignment	1
tm4	1
transducin	1
vasopressin	1

xdeupi's agonist [46 articles] Export

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