xdeupi's binding [44 articles] Export

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	The second transmembrane domain of the human type 1 angiotensin II receptor participates in the formation of the ligand binding pocket and undergoes integral pivoting movement during the process of receptor activation. [My Copy] The Journal of biological chemistry, Vol. 284, No. 18. (1 May 2009), pp. 11922-11929. by Ivana Domazet, Brian J. Holleran, Stéphane S. Martin, et al.Pierre Lavigne, Richard Leduc, Emanuel Escher, Gaétan Guillemette posted to tm2 cys_scanning binding angiotensin activation by xdeupi on 2009-10-23 16:14:47 as
	Conformational selection or induced fit: A flux description of reaction mechanism [My Copy] Proceedings of the National Academy of Sciences, Vol. 106, No. 33. (18 August 2009), pp. 13737-13741. by Gordon G. Hammes, Yu-Chu Chang, Terrence G. Oas posted to pathway binding_kinetics binding activation by xdeupi on 2009-10-07 10:24:54 as along with 4 people and 1 group chemrahul82 anuragsethi pmung barry McCammon
	Exploring Molecular Mechanisms of Ligand Recognition by Opioid Receptors with Metadynamics. [My Copy] Biochemistry (28 September 2009) by Davide Provasi, Andrea Bortolato, Marta Filizola posted to pathways md binding_kinetics binding by xdeupi on 2009-10-06 19:30:24 as
	Ligand entry and exit pathways in the beta2-adrenergic receptor. [My Copy] Journal of molecular biology, Vol. 392, No. 4. (2 October 2009), pp. 1102-1115. by Ting Wang, Yong Duan posted to pathway binding_kinetics binding b2ar by xdeupi on 2009-10-06 17:54:54 as
	Exploring the mechanism of agonist efficacy: a relationship between efficacy and agonist dissociation rate at the muscarinic M3 receptor. [My Copy] Molecular pharmacology, Vol. 76, No. 3. (September 2009), pp. 543-551. by David A. Sykes, Mark R. Dowling, Steven J. Charlton posted to efficacy drug binding_kinetics binding agonist by xdeupi on 2009-10-06 17:50:31 as
	Hot-Spots-Guided Receptor-Based Pharmacophores (HS-Pharm): A Knowledge-Based Approach to Identify Ligand-Anchoring Atoms in Protein Cavities and Prioritize Structure-Based Pharmacophores [My Copy] Journal of Chemical Information and Modeling, Vol. 48, No. 7. (1 July 2008), pp. 1396-1410. by Caterina Barillari, Gilles Marcou, Didier Rognan posted to theory pharmacology ligands drug docking binding b2ar agonist by xdeupi on 2009-10-05 18:45:05 as along with 3 people tbinbal superpyrin higueruelo
	Probing the role of the cation-pi interaction in the binding sites of GPCRs using unnatural amino acids. [My Copy] Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, No. 29. (21 July 2009), pp. 11919-11924. by Michael M. Torrice, Kiowa S. Bower, Henry A. Lester, Dennis A. Dougherty posted to ligands cation-pi binding activation by xdeupi on 2009-08-28 12:57:57 as along with 1 person paulschlesinger
	Allosteric modulation of muscarinic acetylcholine receptors. [My Copy] Current neuropharmacology, Vol. 5, No. 3. (September 2007), pp. 157-167. by K. J. Gregory, P. M. Sexton, A. Christopoulos posted to activation agonist binding kinetics ligands pharmacology by xdeupi on 2009-07-20 18:21:37 as
	The Thermodynamic Landscape of Testosterone Binding to Cytochrome P450 3A4: Ligand Binding and Spin State Equilibria† [My Copy] Biochemistry, Vol. 44, No. 4. (1 February 2005), pp. 1353-1366. by Arthur G. Roberts, Patricia A. Campbell, William M. Atkins posted to binding energy_landscape theory by xdeupi on 2009-06-27 12:33:29 as
	Sequence-Derived Three-Dimensional Pharmacophore Models for G-Protein-Coupled Receptors and Their Application in Virtual Screening [My Copy] Journal of Medicinal Chemistry, Vol. 0, No. 0. (0000) by Thomas Klabunde, Clemens Giegerich, Andreas Evers posted to agonist antagonist binding drug ligands modeling pharmacology by xdeupi on 2009-05-06 09:59:59 as along with 1 person reyez
	Functional role of the extracellular N-terminal domain of neuropeptide Y subfamily receptors in membrane integration and agonist-stimulated internalization. [My Copy] Cellular signalling (22 September 2008) by Diana Lindner, Cornelia Walther, Anja Tennemann, Annette G G. Beck-Sickinger posted to activation binding internalization nterm tm1 by xdeupi on 2008-10-20 22:13:34 as
	Fluorescent GPCR ligands as new tools in pharmacology. [My Copy] Current medicinal chemistry, Vol. 15, No. 21. (2008), pp. 2132-2143. by K. Kuder, K. Kieć-Kononowicz posted to activation agonist binding drug fluorescence imaging ligands by xdeupi on 2008-10-15 10:30:17 as
	The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist [My Copy] Science (2 October 2008), 1164772. by Veli-Pekka Jaakola, Mark T. Griffith, Michael A. Hanson, et al.Vadim Cherezov, Ellen Y. Chien, Robert J. Lane, Adriaan P. Ijzerman, Raymond C. Stevens posted to binding crystallography docking gpcr ligands structure xray by xdeupi on 2008-10-15 10:02:26 as along with 1 person and 1 group cen4ik LabCompMed
	Structure of a β1-adrenergic G-protein-coupled receptor [My Copy] Nature (25 June 2008) by Tony Warne, Maria J. Serrano-Vega, Jillian G. Baker, et al.Rouslan Moukhametzianov, Patricia C. Edwards, Richard Henderson, Andrew G. W. Leslie, Christopher G. Tate, Gebhard F. X. Schertler posted to b2ar binding docking drug ligands structure xray by xdeupi on 2008-09-16 10:15:17 as along with 2 people and 2 groups merj TonyIvetac LabCompMed McCammon
	Recruitment of beta-arrestin2 to the dopamine D2 receptor: Insights into anti-psychotic and anti-parkinsonian drug receptor signaling. [My Copy] Neuropharmacology (8 April 2008) by Ib V V. Klewe, Søren M M. Nielsen, Louise Tarpø, et al.Eneko Urizar, Concetta Dipace, Jonathan A A. Javitch, Ulrik Gether, Jan Egebjerg, Kenneth V V. Christensen posted to activation active-state agonist arrestin biased_agonism binding disease fluorescence imaging internalization pharmacology by xdeupi on 2008-05-13 16:24:49 as
	Chemogenomic approaches to rational drug design [My Copy] Br J Pharmacol, Vol. 152, No. 1. (29 May 2007), pp. 38-52. by D. Rognan posted to agonist binding drug ligands pharmacology priviledged_structures by xdeupi on 2008-03-28 15:54:47 as along with 4 people and 3 groups jmrivort jerome_ucsf_slb guhjy tjimenez LabCompMed G-quadruplex Supramolecular
	Chloroethylclonidine and 2-aminoethyl methanethiosulfonate recognize two different conformations of the human alpha(2A)-adrenergic receptor. [My Copy] J Biol Chem, Vol. 274, No. 31. (30 July 1999), pp. 21867-21872. by A. Marjamäki, H. Frang, M. Pihlavisto, et al.A. M. Hoffrén, T. Salminen, M. S. Johnson, J. Kallio, J. A. Javitch, M. Scheinin posted to activation binding cys_scanning drug ligands tm5 by xdeupi on 2008-03-07 15:14:37 as along with 1 group LabCompMed
	Identification of the Binding Sites of the SR49059 Nonpeptide Antagonist into the V1a Vasopressin Receptor Using Sulfydryl-reactive Ligands and Cysteine Mutants as Chemical Sensors [My Copy] J. Biol. Chem., Vol. 278, No. 41. (10 October 2003), pp. 40010-40019. by Chouaib Tahtaoui, Marie-Noelle Balestre, Philippe Klotz, et al.Didier Rognan, Claude Barberis, Bernard Mouillac, Marcel Hibert posted to binding cys_scanning peptide vasopressin by xdeupi on 2008-02-28 16:16:02 as
	Critical Role for the Second Extracellular Loop in the Binding of Both Orthosteric and Allosteric G Protein-coupled Receptor Ligands [My Copy] J. Biol. Chem., Vol. 282, No. 35. (31 August 2007), pp. 25677-25686. by Vimesh A. Avlani, Karen J. Gregory, Craig J. Morton, Michael W. Parker, Patrick M. Sexton, Arthur Christopoulos posted to activation binding ecl2 ligands loops structure by xdeupi on 2007-06-29 21:12:42 as along with 1 group LabCompMed
	Structural models of class a g protein-coupled receptors as a tool for drug design: insights on transmembrane bundle plasticity. [My Copy] Curr Top Med Chem, Vol. 7, No. 10. (2007), pp. 999-1006. by X. Deupi, N. Dölker, M. L. López-Rodríguez, M. Campillo, J. A. Ballesteros, L. Pardo posted to binding gpcr modeling plasticity structure by xdeupi on 2007-05-28 08:51:54 as along with 1 group LabCompMed
	Chromophore Channeling in the G-Protein Coupled Receptor Rhodopsin. [My Copy] J Am Chem Soc (15 May 2007) by Ting Wang, Yong Duan posted to activation agonist amber binding ligands md modeling rhodopsin by xdeupi on 2007-05-21 10:04:04 as along with 1 group LabCompMed
	Multiple residues in the second extracellular loop are critical for M3 muscarinic acetylcholine receptor activation. [My Copy] J Biol Chem, Vol. 282, No. 10. (9 March 2007), pp. 7385-7396. by M. Scarselli, B. Li, S. K. Kim, J. Wess posted to activation amine binding ecl2 loops mutation by xdeupi on 2007-04-23 10:28:29 as along with 1 person and 1 group IrinaMoreira LabCompMed
	Systematic analysis of the entire second extracellular loop of the V1a vasopressin receptor: Key residues, conserved throughout a G-protein-coupled receptor family, identified. [My Copy] J Biol Chem (2 April 2007) by Matthew Conner, Stuart R R. Hawtin, John Simms, et al.Denise L L. Wootten, Zoe Lawson, Alex C C. Conner, Rosemary A A. Parslow, Mark Wheatley posted to activation amine binding ecl2 gpcr loops by xdeupi on 2007-04-10 18:59:06 as along with 1 group LabCompMed
	The first extracellular loop of the Saccharomyces cerevisiae GPCR STE2P undergoes a conformational change upon ligand binding. [My Copy] J Biol Chem (9 February 2007) by Melinda Hauser, Sarah Kauffman, Byung-Kwon K. Lee, Fred Naider, Jeffrey M M. Becker posted to activation binding gpcr loops by xdeupi on 2007-02-20 10:09:06 as along with 1 group LabCompMed
	Identification of an agonist-induced conformational change occurring adjacent to the ligand-binding pocket of the M(3) muscarinic acetylcholine receptor. [My Copy] J Biol Chem, Vol. 280, No. 41. (14 October 2005), pp. 34849-34858. by S. J. Han, F. F. Hamdan, S. K. Kim, et al.K. A. Jacobson, L. M. Bloodworth, B. Li, J. Wess posted to ligands cation-pi binding agonist by xdeupi on 2007-01-15 16:08:15 as along with 1 group LabCompMed
	Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp. [My Copy] Science, Vol. 271, No. 5246. (12 January 1996), pp. 163-168. by D. A. Dougherty posted to trp cation-pi binding by xdeupi on 2007-01-12 17:18:14 as along with 3 people and 1 group medic0747 superpyrin viktor21614 LabCompMed
	The Cationminus signpi Interaction. [My Copy] Chem Rev, Vol. 97, No. 5. (5 August 1997), pp. 1303-1324. by Jennifer C. Ma, Dennis A. Dougherty posted to trp ligands histamine cation-pi binding b2ar by xdeupi on 2007-01-11 14:28:54 as along with 1 group LabCompMed
	GluVII:06--a highly conserved and selective anchor point for non-peptide ligands in chemokine receptors. [My Copy] Curr Top Med Chem, Vol. 6, No. 13. (2006), pp. 1319-1333. by M. M. Rosenkilde, T. W. Schwartz posted to modeling ligands ionic chemokine binding agonist by xdeupi on 2007-01-10 14:45:13 as along with 1 group LabCompMed
	dummy [My Copy] by Dummy posted to 5ht1a activation agonist amber amine arrestin b2ar bimane binding cam ccr5 channel chemokine chimera crystallography cterm cxcr1 d250 dimer disease drug dry dynamics ecl2 evolution expression fluorescence folding fret genome gly gpcr gproteins hbond helix helix8 histamine hormone icl3 imaging internalization ionic leukotriene lhr ligands lipids lock loops md membrane modeling mutation n745 n749 nmr npxxy nterm opioid pharmacology polymorphism pro-kink protonation review rhodopsin s542 sequence ser spin_labeling structure switch thr thyrotropin tm2 tm3 tm5 tm6 tm7 toggle transmembrane trp txp w648 by xdeupi on 2006-10-30 12:30:16 as along with 2 people and 1 group jessicaopacic ivanrt LabCompMed
	Modeling and active site refinement for G protein-coupled receptors: application to the beta-2 adrenergic receptor. [My Copy] J Comput Aided Mol Des (13 October 2006) by Stanley R. Krystek, S R. Kimura, Andrew J. Tebben posted to b2ar binding drug ligands modeling pharmacology by xdeupi on 2006-10-27 09:43:03 as along with 1 person and 1 group daevans LabCompMed
	Novel mutants of the human beta1-adrenergic receptor reveal amino acids relevant for receptor activation. [My Copy] J Biol Chem, Vol. 281, No. 26. (30 June 2006), pp. 18120-18125. by B. Behr, C. Hoffmann, G. Ottolina, K. N. Klotz posted to activation agonist b2ar binding drug ligands modeling mutation pharmacology structure by xdeupi on 2006-09-05 11:05:20 as along with 1 group LabCompMed
	Data-Driven Analysis in Drug Discovery [My Copy] Journal of Receptors and Signal Transduction, Vol. 26, No. 4. (August 2006), pp. 299-327. by Terry Kenakin posted to agonist binding drug ligands pharmacology by xdeupi on 2006-07-17 16:28:05 as along with 1 group LabCompMed
	Changes in interhelical hydrogen bonding upon rhodopsin activation. [My Copy] J Mol Biol, Vol. 347, No. 4. (8 April 2005), pp. 803-812. by A. B. Patel, E. Crocker, P. J. Reeves, et al.E. V. Getmanova, M. Eilers, H. G. Khorana, S. O. Smith posted to activation b2ar binding hbond helix ligands nmr pro-kink rhodopsin ser structure switch tm5 tm6 toggle by xdeupi on 2006-06-01 13:51:11 as along with 1 group LabCompMed
	Role of the retinal hydrogen bond network in rhodopsin Schiff base stability and hydrolysis. [My Copy] J Biol Chem, Vol. 279, No. 53. (31 December 2004), pp. 55886-55894. by J. M. Janz, D. L. Farrens posted to activation binding rhodopsin by xdeupi on 2006-05-29 11:58:42 as along with 1 group LabCompMed
	Molecular evolution of adrenoceptors and dopamine receptors: implications for the binding of catecholamines. [My Copy] J Med Chem, Vol. 49, No. 5. (9 March 2006), pp. 1706-1719. by H. Xhaard, V. V. Rantanen, T. Nyrönen, M. S. Johnson posted to agonist b2ar binding gpcr ligands modeling by xdeupi on 2006-03-06 10:11:30 as along with 1 group LabCompMed
	A chemogenomic analysis of the transmembrane binding cavity of human G-protein-coupled receptors. [My Copy] Proteins, Vol. 62, No. 2. (1 February 2006), pp. 509-538. by J. S. Surgand, J. Rodrigo, E. Kellenberger, D. Rognan posted to binding gpcr ligands transmembrane by xdeupi on 2006-03-01 16:33:01 as along with 1 person and 1 group naweill LabCompMed
	Principal pathway coupling agonist binding to channel gating in nicotinic receptors [My Copy] Nature, Vol. 438, No. 7065. (10 November 2005), pp. 243-247. by Won Y. Lee, Steven M. Sine posted to activation agonist binding channel ser by xdeupi on 2006-01-27 12:32:01 as along with 1 person and 3 groups barry structural_bioinformatics Bioinformatics LabCompMed
	Sequential binding of agonists to the beta2 adrenoceptor. Kinetic evidence for intermediate conformational states. [My Copy] J Biol Chem, Vol. 279, No. 1. (2 January 2004), pp. 686-691. by G. Swaminath, Y. Xiang, T. W. Lee, J. Steenhuis, C. Parnot, B. K. Kobilka posted to activation agonist b2ar binding ligands tm6 by xdeupi on 2005-12-16 10:19:18 as along with 1 person and 1 group jddowney LabCompMed
	Agonist binding: a multistep process. [My Copy] Mol Pharmacol, Vol. 65, No. 5. (May 2004), pp. 1060-1062. by B. Kobilka posted to activation agonist b2ar binding gpcr by xdeupi on 2005-11-02 22:50:37 as along with 1 group LabCompMed
	Evolutionary trace of G protein-coupled receptors reveals clusters of residues that determine global and class-specific functions. [My Copy] J Biol Chem, Vol. 279, No. 9. (27 February 2004), pp. 8126-8132. by S. Madabushi, A. K. Gross, A. Philippi, E. C. Meng, T. G. Wensel, O. Lichtarge posted to activation binding gpcr sequence switch by xdeupi on 2005-11-01 20:03:29 as along with 2 people and 1 group gbart sriram_s LabCompMed
	Possible role of the 11-cis-retinyl conformation in controlling the dual decay processes of excited rhodopsin. [My Copy] Proc Natl Acad Sci U S A, Vol. 102, No. 31. (2 August 2005), pp. 10783-10787. by R. S. Liu, G. S. Hammond, T. Mirzadegan posted to activation binding gpcr rhodopsin by xdeupi on 2005-11-01 19:48:57 as along with 1 group LabCompMed
	Linking agonist binding to histamine H1 receptor activation [My Copy] Nat Chem Biol, Vol. 1, No. 2. (July 2005), pp. 98-103. by Aldo Jongejan, Martijn Bruysters, Juan A. Ballesteros, et al.Eric Haaksma, Remko A. Bakker, Leonardo Pardo, Rob Leurs posted to activation agonist binding histamine n745 npxxy by xdeupi on 2005-11-01 01:19:58 as along with 1 group LabCompMed
	The forgotten serine. A critical role for Ser-2035.42 in ligand binding to and activation of the beta 2-adrenergic receptor. [My Copy] J Biol Chem, Vol. 275, No. 48. (1 December 2000), pp. 37779-37788. by G. Liapakis, J. A. Ballesteros, S. Papachristou, W. C. Chan, X. Chen, J. A. Javitch posted to activation agonist b2ar binding s542 ser tm5 by xdeupi on 2005-11-01 01:02:07 as along with 1 group LabCompMed
	The binding site of aminergic G protein-coupled receptors: the transmembrane segments and second extracellular loop. [My Copy] Annu Rev Pharmacol Toxicol, Vol. 42 (2002), pp. 437-467. by L. Shi, J. A. Javitch posted to agonist binding ecl2 gpcr helix loops transmembrane by xdeupi on 2005-11-01 01:00:19 as along with 1 person and 1 group IrinaMoreira LabCompMed

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activation	173
gpcr	112
structure	89
rhodopsin	79
review	65
modeling	62
b2ar	58
dynamics	56
helix	50
transmembrane	47
agonist	46
binding	44
theory	43
ligands	41
drug	36
md	35
switch	34
membrane_proteins	31
pharmacology	31
crystallography	30
nmr	30
membrane	26
gproteins	24
dimer	20
fluorescence	18
sequence	17
ser	17
active-state	15
pro-kink	15
folding	14
fret	14
genome	14
loops	14
flexibility	13
disease	12
tm6	12
cterm	11
mutation	11
retinal	11
amber	10
energy_landscape	10
evolution	10
toggle	10
docking	9
kinetics	9
lipids	9
neurokinin	9
tm5	9
arrestin	8
chemokine	8
gpcrs	8
hbond	8
helix8	8
imaging	8
bimane	7
cancer	7
channel	7
ecl2	7
gly	7
icl3	7
ionic	7
lmc_101	7
plasticity	7
protonation	7
tm3	7
w648	7
cation-pi	6
ccr5	6
cys_scanning	6
d250	6
internalization	6
npxxy	6
opioid	6
thyrotropin	6
tm2	6
xray	6
amine	5
binding_kinetics	5
conformational_changes	5
dimerization	5
dry	5
expression	5
lock	5
polymorphism	5
spectroscopy	5
thr	5
trp	5
antagonist	4
cam	4
cholesterol	4
disorder	4
hormone	4
n749	4
nterm	4
pathway	4
tm7	4
water	4
angiotensin	3
biased_agonism	3
cxcr1	3
grk	3
histamine	3
n745	3
oligomerization	3
spin_labeling	3
toac	3
webserver	3
5ht1a	2
chimera	2
crosslinking	2
em	2
leukotriene	2
lhr	2
networks	2
pathways	2
phylogeny	2
s542	2
solvation	2
tm1	2
tmhs	2
txp	2
b1ar	1
binding_site	1
class_c	1
efficacy	1
gaba	1
induced_fit	1
inverse_agonist	1
kinase	1
kinks	1
metai	1
oligomers	1
peptide	1
priviledged_structures	1
protein_docking	1
selectivity	1
sequence_alignment	1
tm4	1
transducin	1
vasopressin	1

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