xdeupi's drug [36 articles] Export

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	Hetero-oligomerization of CCR2, CCR5 and CXCR4 and the protean effects of "selective"-antagonists. [My Copy] The Journal of biological chemistry (15 September 2009) by Denis Sohy, Hideaki Yano, Patricia de Nadai, et al.Eneko Urizar, Aude Guillabert, Jonathan A. Javitch, Marc Parmentier, Jean-Yves Y. Springael posted to oligomerization drug chemokine antagonist by xdeupi on 2009-10-06 19:26:05 as
	Computational analysis of membrane proteins: the largest class of drug targets. [My Copy] Drug discovery today (3 September 2009) by Yalini Arinaminpathy, Ekta Khurana, Donald M. Engelman, Mark B. Gerstein posted to theory membrane_proteins drug by xdeupi on 2009-10-06 19:23:18 as
	Exploring the mechanism of agonist efficacy: a relationship between efficacy and agonist dissociation rate at the muscarinic M3 receptor. [My Copy] Molecular pharmacology, Vol. 76, No. 3. (September 2009), pp. 543-551. by David A. Sykes, Mark R. Dowling, Steven J. Charlton posted to efficacy drug binding_kinetics binding agonist by xdeupi on 2009-10-06 17:50:31 as
	Definition of the G Protein-Coupled Receptor Transmembrane Bundle Binding Pocket and Calculation of Receptor Similarities for Drug Design [My Copy] Journal of Medicinal Chemistry, Vol. 52, No. 14. (23 July 2009), pp. 4429-4442. by David E. Gloriam, Steven M. Foord, Frank E. Blaney, Stephen L. Garland posted to theory gpcr drug binding_site by xdeupi on 2009-10-06 17:42:06 as
	Web Server To Identify Similarity of Amino Acid Motifs to Compounds (SAAMCO) [My Copy] Journal of Chemical Information and Modeling, Vol. 48, No. 7. (1 July 2008), pp. 1524-1529. by Fergal P. Casey, Norman E. Davey, Ivan Baran, Radka S. Varekova, Denis C. Shields posted to webserver theory pharmacology ligands drug by xdeupi on 2009-10-05 18:46:59 as along with 1 person higueruelo
	Hot-Spots-Guided Receptor-Based Pharmacophores (HS-Pharm): A Knowledge-Based Approach to Identify Ligand-Anchoring Atoms in Protein Cavities and Prioritize Structure-Based Pharmacophores [My Copy] Journal of Chemical Information and Modeling, Vol. 48, No. 7. (1 July 2008), pp. 1396-1410. by Caterina Barillari, Gilles Marcou, Didier Rognan posted to theory pharmacology ligands drug docking binding b2ar agonist by xdeupi on 2009-10-05 18:45:05 as along with 3 people tbinbal superpyrin higueruelo
	Sequence-Derived Three-Dimensional Pharmacophore Models for G-Protein-Coupled Receptors and Their Application in Virtual Screening [My Copy] Journal of Medicinal Chemistry, Vol. 0, No. 0. (0000) by Thomas Klabunde, Clemens Giegerich, Andreas Evers posted to agonist antagonist binding drug ligands modeling pharmacology by xdeupi on 2009-05-06 09:59:59 as along with 1 person reyez
	Development of low molecular weight CXCR4 antagonists by exploratory structural tuning of cyclic tetra- and pentapeptide-scaffolds towards the treatment of HIV infection, cancer metastasis and rheumatoid arthritis. [My Copy] Current medicinal chemistry, Vol. 14, No. 1. (2007), pp. 93-102. by H. Tamamura, H. Tsutsumi, H. Masuno, N. Fujii posted to antagonist cancer chemokine disease drug by xdeupi on 2009-01-12 15:53:35 as
	A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor. [My Copy] Structure (London, England : 1993), Vol. 16, No. 6. (June 2008), pp. 897-905. by M. A. Hanson, V. Cherezov, M. T. Griffith, et al.C. B. Roth, V. P. Jaakola, E. Y. Chien, J. Velasquez, P. Kuhn, R. C. Stevens posted to b2ar cholesterol crystallography drug ligands structure by xdeupi on 2009-01-09 12:05:17 as along with 1 person and 1 group merj LabCompMed
	Physiological relevance of GPCR oligomerization and its impact on drug discovery. [My Copy] Drug discovery today, Vol. 13, No. 23-24. (14 December 2008), pp. 1059-1066. by Rosemarie Panetta, Michael T. Greenwood posted to dimer disease drug gpcr ligands pharmacology review by xdeupi on 2008-10-16 09:57:50 as along with 1 person guhjy
	Fluorescent GPCR ligands as new tools in pharmacology. [My Copy] Current medicinal chemistry, Vol. 15, No. 21. (2008), pp. 2132-2143. by K. Kuder, K. Kieć-Kononowicz posted to activation agonist binding drug fluorescence imaging ligands by xdeupi on 2008-10-15 10:30:17 as
	Structure of a β1-adrenergic G-protein-coupled receptor [My Copy] Nature (25 June 2008) by Tony Warne, Maria J. Serrano-Vega, Jillian G. Baker, et al.Rouslan Moukhametzianov, Patricia C. Edwards, Richard Henderson, Andrew G. W. Leslie, Christopher G. Tate, Gebhard F. X. Schertler posted to b2ar binding docking drug ligands structure xray by xdeupi on 2008-09-16 10:15:17 as along with 2 people and 2 groups merj TonyIvetac LabCompMed McCammon
	Clinical consequences of ADR2 polymorphisms [My Copy] Pharmacogenomics, Vol. 9, No. 3. (March 2008), pp. 349-358. by Hawkins, A. Gregory, Weiss, T. Scott, Bleecker, R. Eugene posted to b2ar disease drug genome pharmacology polymorphism review by xdeupi on 2008-05-03 17:12:39 as
	Functional assays as prismatic views of drug activity: relevance to new drug discovery. [My Copy] Journal of receptor and signal transduction research, Vol. 28, No. 1. (2008), pp. 109-125. by T. Kenakin posted to biased_agonism chemokine drug pharmacology review by xdeupi on 2008-05-03 17:03:08 as
	Chemogenomic approaches to rational drug design [My Copy] Br J Pharmacol, Vol. 152, No. 1. (29 May 2007), pp. 38-52. by D. Rognan posted to agonist binding drug ligands pharmacology priviledged_structures by xdeupi on 2008-03-28 15:54:47 as along with 4 people and 3 groups jmrivort jerome_ucsf_slb guhjy tjimenez LabCompMed G-quadruplex Supramolecular
	Chloroethylclonidine and 2-aminoethyl methanethiosulfonate recognize two different conformations of the human alpha(2A)-adrenergic receptor. [My Copy] J Biol Chem, Vol. 274, No. 31. (30 July 1999), pp. 21867-21872. by A. Marjamäki, H. Frang, M. Pihlavisto, et al.A. M. Hoffrén, T. Salminen, M. S. Johnson, J. Kallio, J. A. Javitch, M. Scheinin posted to activation binding cys_scanning drug ligands tm5 by xdeupi on 2008-03-07 15:14:37 as along with 1 group LabCompMed
	beta-Arrestin-biased Agonism at the beta2-Adrenergic Receptor. [My Copy] J Biol Chem, Vol. 283, No. 9. (29 February 2008), pp. 5669-5676. by M. T. Drake, J. D. Violin, E. J. Whalen, J. W. Wisler, S. K. Shenoy, R. J. Lefkowitz posted to activation agonist arrestin b2ar biased_agonism drug gproteins imaging internalization ligands pharmacology by xdeupi on 2008-02-27 10:39:07 as along with 1 group LabCompMed
	Smart drug discovery leveraging innovative technologies and predictive knowledge. [My Copy] Nat Chem Biol, Vol. 2, No. 12. (December 2006), pp. 646-648. by T. K. Sawyer posted to drug pharmacology by xdeupi on 2007-04-23 16:56:56 as along with 1 group LabCompMed
	Chemical Biology & Drug Design: First Anniversary - 2007! [My Copy] Chem Biol Drug Des, Vol. 69, No. 1. (January 2007), pp. 1-2. by Tomi K K. Sawyer posted to drug pharmacology review by xdeupi on 2007-04-23 16:56:17 as along with 1 group LabCompMed
	Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR. [My Copy] The EMBO journal, Vol. 26, No. 1. (10 January 2007), pp. 53-64. by Yutong Sun, Jianyun Huang, Yang Xiang, et al.Murat Bastepe, Harald Jüppner, Brian K. Kobilka, Jillian J. Zhang, Xin-Yun Y. Huang posted to activation b2ar drug pharmacology switch by xdeupi on 2007-03-21 11:13:23 as along with 2 people and 1 group diod Guff32 LabCompMed
	Subclassification and nomenclature of alpha- and beta-adrenoceptors. [My Copy] Curr Top Med Chem, Vol. 7, No. 2. (2007), pp. 129-134. by J. P. Hieble posted to agonist b2ar drug genome ligands pharmacology review by xdeupi on 2007-03-12 14:33:19 as along with 1 group LabCompMed
	Recent advances in identification and characterization of beta-adrenoceptor agonists and antagonists. [My Copy] Curr Top Med Chem, Vol. 7, No. 2. (2007), pp. 207-216. by J. P. Hieble posted to agonist b2ar drug ligands pharmacology by xdeupi on 2007-03-12 14:32:04 as along with 1 group LabCompMed
	Drugs, their targets and the nature and number of drug targets [My Copy] Nature Reviews Drug Discovery, Vol. 5, No. 10., pp. 821-834. by Peter Imming, Christian Sinning, Achim Meyer posted to review ligands gpcr genome drug by xdeupi on 2007-01-22 17:55:08 as along with 4 people and 1 group kuhn massivemayhem Ao_Li2007 yaredo LabCompMed
	Latest development in drug discovery on G protein-coupled receptors. [My Copy] Curr Protein Pept Sci, Vol. 7, No. 5. (October 2006), pp. 465-470. by K. Lundstrom posted to cancer drug gpcr review by xdeupi on 2006-11-04 12:42:42 as along with 1 person and 1 group denissohy LabCompMed
	I want a new drug: G-protein-coupled receptors in drug development. [My Copy] Drug Discov Today, Vol. 11, No. 11-12. (June 2006), pp. 481-493. by S. Schlyer, R. Horuk posted to cancer drug gpcr ligands pharmacology review by xdeupi on 2006-11-04 12:41:53 as along with 1 person and 1 group zimbo1 LabCompMed
	dummy [My Copy] by Dummy posted to 5ht1a activation agonist amber amine arrestin b2ar bimane binding cam ccr5 channel chemokine chimera crystallography cterm cxcr1 d250 dimer disease drug dry dynamics ecl2 evolution expression fluorescence folding fret genome gly gpcr gproteins hbond helix helix8 histamine hormone icl3 imaging internalization ionic leukotriene lhr ligands lipids lock loops md membrane modeling mutation n745 n749 nmr npxxy nterm opioid pharmacology polymorphism pro-kink protonation review rhodopsin s542 sequence ser spin_labeling structure switch thr thyrotropin tm2 tm3 tm5 tm6 tm7 toggle transmembrane trp txp w648 by xdeupi on 2006-10-30 12:30:16 as along with 2 people and 1 group jessicaopacic ivanrt LabCompMed
	Modeling and active site refinement for G protein-coupled receptors: application to the beta-2 adrenergic receptor. [My Copy] J Comput Aided Mol Des (13 October 2006) by Stanley R. Krystek, S R. Kimura, Andrew J. Tebben posted to b2ar binding drug ligands modeling pharmacology by xdeupi on 2006-10-27 09:43:03 as along with 1 person and 1 group daevans LabCompMed
	A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure. [My Copy] Proc Natl Acad Sci U S A, Vol. 103, No. 30. (25 July 2006), pp. 11288-11293. by S. B. Liggett, J. Mialet-Perez, S. Thaneemit-Chen, et al.S. A. Weber, S. M. Greene, D. Hodne, B. Nelson, J. Morrison, M. J. Domanski, L. E. Wagoner, W. T. Abraham, J. L. Anderson, J. F. Carlquist, H. J. Krause-Steinrauf, L. C. Lazzeroni, J. D. Port, P. W. Lavori, M. R. Bristow posted to b2ar disease drug genome helix8 ligands polymorphism by xdeupi on 2006-09-05 11:38:25 as along with 1 group LabCompMed
	Novel mutants of the human beta1-adrenergic receptor reveal amino acids relevant for receptor activation. [My Copy] J Biol Chem, Vol. 281, No. 26. (30 June 2006), pp. 18120-18125. by B. Behr, C. Hoffmann, G. Ottolina, K. N. Klotz posted to activation agonist b2ar binding drug ligands modeling mutation pharmacology structure by xdeupi on 2006-09-05 11:05:20 as along with 1 group LabCompMed
	G proteins in drug screening: from analysis of receptor-G protein specificity to manipulation of GPCR-mediated signalling pathways. [My Copy] Curr Pharm Des, Vol. 12, No. 14. (2006), pp. 1703-1715. by E. Kostenis posted to activation cterm drug ecl2 gpcr gproteins pharmacology by xdeupi on 2006-09-05 09:59:05 as along with 1 group LabCompMed
	Determining the Potency and Molecular Mechanism of Action of Insurmountable Antagonists. [My Copy] J Pharmacol Exp Ther (20 July 2006) by Terry P P. Kenakin, Stephen Jenkinson, Christian Watson posted to activation drug ligands agonist pharmacology by xdeupi on 2006-09-05 09:51:58 as along with 1 group LabCompMed
	GPCR agonists and antagonists in the clinic. [My Copy] Med Chem, Vol. 1, No. 4. (July 2005), pp. 405-421. by J. D. Tyndall, R. Sandilya posted to agonist drug gpcr ligands pharmacology by xdeupi on 2006-07-24 10:18:01 as along with 1 group LabCompMed
	Data-Driven Analysis in Drug Discovery [My Copy] Journal of Receptors and Signal Transduction, Vol. 26, No. 4. (August 2006), pp. 299-327. by Terry Kenakin posted to agonist binding drug ligands pharmacology by xdeupi on 2006-07-17 16:28:05 as along with 1 group LabCompMed
	The identification of ligands at orphan G-protein coupled receptors. [My Copy] Annu Rev Pharmacol Toxicol, Vol. 44 (2004), pp. 43-66. by A. Wise, S. C. Jupe, S. Rees posted to drug gpcr ligands by xdeupi on 2006-03-01 16:35:26 as along with 1 group LabCompMed
	GPCR antitarget modeling: pharmacophore models for biogenic amine binding GPCRs to avoid GPCR-mediated side effects. [My Copy] Chembiochem, Vol. 6, No. 5. (May 2005), pp. 876-889. by T. Klabunde, A. Evers posted to amine drug by xdeupi on 2006-01-11 11:25:41 as along with 1 group LabCompMed
	GLIDA: GPCR-ligand database for chemical genomic drug discovery. [My Copy] Nucleic Acids Res, Vol. 34, No. Database issue. (1 January 2006) by Y. Okuno, J. Yang, K. Taneishi, H. Yabuuchi, G. Tsujimoto posted to drug by xdeupi on 2006-01-11 11:22:31 as along with 1 person and 1 group kuhn LabCompMed

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activation	171
gpcr	110
structure	89
rhodopsin	79
review	64
modeling	62
b2ar	58
dynamics	56
helix	50
transmembrane	47
agonist	46
binding	44
theory	42
ligands	41
drug	36
md	35
switch	34
membrane_proteins	31
crystallography	30
nmr	30
pharmacology	30
membrane	26
gproteins	23
dimer	20
fluorescence	18
sequence	17
ser	17
active-state	15
folding	14
fret	14
genome	14
loops	14
pro-kink	14
flexibility	13
disease	12
tm6	12
cterm	11
mutation	11
retinal	11
amber	10
evolution	10
toggle	10
docking	9
energy_landscape	9
kinetics	9
lipids	9
neurokinin	9
tm5	9
arrestin	8
chemokine	8
gpcrs	8
hbond	8
helix8	8
imaging	8
bimane	7
cancer	7
channel	7
ecl2	7
gly	7
icl3	7
ionic	7
lmc_101	7
plasticity	7
protonation	7
tm3	7
w648	7
cation-pi	6
ccr5	6
cys_scanning	6
d250	6
internalization	6
npxxy	6
opioid	6
thyrotropin	6
tm2	6
xray	6
amine	5
binding_kinetics	5
conformational_changes	5
dimerization	5
dry	5
expression	5
lock	5
polymorphism	5
spectroscopy	5
thr	5
trp	5
antagonist	4
cam	4
cholesterol	4
disorder	4
hormone	4
n749	4
nterm	4
pathway	4
tm7	4
water	4
angiotensin	3
biased_agonism	3
cxcr1	3
grk	3
histamine	3
n745	3
oligomerization	3
spin_labeling	3
toac	3
webserver	3
5ht1a	2
chimera	2
crosslinking	2
em	2
leukotriene	2
lhr	2
networks	2
pathways	2
phylogeny	2
s542	2
solvation	2
tm1	2
tmhs	2
txp	2
b1ar	1
binding_site	1
class_c	1
efficacy	1
gaba	1
induced_fit	1
inverse_agonist	1
kinase	1
kinks	1
metai	1
oligomers	1
peptide	1
priviledged_structures	1
proline	1
protein_docking	1
sequence_alignment	1
tm4	1
transducin	1
vasopressin	1

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