Phasic dopamine release evoked by abused substances requires cannabinoid receptor activation.

@article{citeulike:2800326, abstract = {Transient surges of dopamine in the nucleus accumbens are associated with drug seeking. Using a voltammetric sensor with high temporal and spatial resolution, we demonstrate differences in the temporal profile of dopamine concentration transients caused by acute doses of nicotine, ethanol, and cocaine in the nucleus accumbens shell of freely moving rats. Despite differential release dynamics, all drug effects are uniformly inhibited by administration of rimonabant, a cannabinoid receptor (CB1) antagonist, suggesting that an increase in endocannabinoid tone facilitates the effects of commonly abused drugs on subsecond dopamine release. These time-resolved chemical measurements provide unique insight into the neurobiological effectiveness of rimonabant in treating addictive disorders.}, address = {Department of Chemistry and Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290, USA.}, author = {Cheer, J. F. and Wassum, K. M. and Sombers, L. A. and Heien, M. L. and Ariansen, J. L. and Aragona, B. J. and Phillips, P. E. and Wightman, R. M.}, citeulike-article-id = {2800326}, doi = {10.1523/JNEUROSCI.4152-06.2007}, issn = {1529-2401}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, keywords = {abuse, accumbens, antagonist, cannabinoid, cannabis, cb1, cocaine, dopamine, drug, na, nucleus, receptor, recreational, rimonabant}, month = {January}, number = {4}, pages = {791--795}, posted-at = {2008-05-15 01:02:26}, priority = {2}, title = {Phasic dopamine release evoked by abused substances requires cannabinoid receptor activation.}, url = {http://dx.doi.org/10.1523/JNEUROSCI.4152-06.2007}, volume = {27}, year = {2007} }

TY - JOUR ID - citeulike:2800326 L3 - citeulike-article-id:2800326 N2 - Transient surges of dopamine in the nucleus accumbens are associated with drug seeking. Using a voltammetric sensor with high temporal and spatial resolution, we demonstrate differences in the temporal profile of dopamine concentration transients caused by acute doses of nicotine, ethanol, and cocaine in the nucleus accumbens shell of freely moving rats. Despite differential release dynamics, all drug effects are uniformly inhibited by administration of rimonabant, a cannabinoid receptor (CB1) antagonist, suggesting that an increase in endocannabinoid tone facilitates the effects of commonly abused drugs on subsecond dopamine release. These time-resolved chemical measurements provide unique insight into the neurobiological effectiveness of rimonabant in treating addictive disorders. IS - 4 JF - The Journal of neuroscience : the official journal of the Society for Neuroscience SN - 1529-2401 AD - Department of Chemistry and Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290, USA. EP - 795 TI - Phasic dopamine release evoked by abused substances requires cannabinoid receptor activation. VL - 27 SP - 791 KW - abuse KW - accumbens KW - antagonist KW - cannabinoid KW - cannabis KW - cb1 KW - cocaine KW - dopamine KW - drug KW - na KW - nucleus KW - receptor KW - recreational KW - rimonabant AU - Cheer, JF AU - Wassum, KM AU - Sombers, LA AU - Heien, ML AU - Ariansen, JL AU - Aragona, BJ AU - Phillips, PE AU - Wightman, RM PY - 2007/01/24/ UR - http://dx.doi.org/10.1523/JNEUROSCI.4152-06.2007 ER -