CCR5-Delta32 allele frequencies in Ashkenazi Jews. Export

@article{citeulike:1777606, abstract = {This study was carried out to determine the 32-bp deletion allele frequencies in the CCR5 gene (CCR5-Delta32) in various populations of Jews of eastern European origin (Ashkenazi Jews). The total population sample (n = 351) represented Ashkenazi Jews originating from seven geographic groups in Europe. The overall frequency of the CCR5-Delta32 allele was elevated (13.7\%), although some important differences in frequencies occurred among the seven countries included in the survey; the frequency was highest (25.9\%) in those of Lithuanian origin. There is an apparent trend (r = 0.74) involving a lowering of the Delta32 allele frequencies moving from north to south in the seven populations tested. The Delta32 frequencies obtained were compared to those already published for non-Jewish populations inhabiting the same countries and the differences in frequencies were not significant, with the exception of Lithuania (chi(2) = 2.20, p < 0.03). Founder effect and genetic drift are proposed to explain the elevated values observed in Ashkenazi Jews and those originating from Lithuania.}, address = {Center of Neurogenetics, Paris, France. Lucotte@hotmail.com}, author = {Lucotte, G. and Smets, P.}, citeulike-article-id = {1777606}, citeulike-linkout-0 = {http://dx.doi.org/10.1089/109065703322783716}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15000812}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15000812}, doi = {10.1089/109065703322783716}, issn = {1090-6576}, journal = {Genet Test}, keywords = {ashkenazi, ccr5delta32}, number = {4}, pages = {333--337}, posted-at = {2007-11-06 19:59:58}, priority = {2}, title = {CCR5-Delta32 allele frequencies in Ashkenazi Jews.}, url = {http://dx.doi.org/10.1089/109065703322783716}, volume = {7}, year = {2003} }

TY - JOUR ID - citeulike:1777606 L3 - citeulike-article-id:1777606 N2 - This study was carried out to determine the 32-bp deletion allele frequencies in the CCR5 gene (CCR5-Delta32) in various populations of Jews of eastern European origin (Ashkenazi Jews). The total population sample (n = 351) represented Ashkenazi Jews originating from seven geographic groups in Europe. The overall frequency of the CCR5-Delta32 allele was elevated (13.7%), although some important differences in frequencies occurred among the seven countries included in the survey; the frequency was highest (25.9%) in those of Lithuanian origin. There is an apparent trend (r = 0.74) involving a lowering of the Delta32 allele frequencies moving from north to south in the seven populations tested. The Delta32 frequencies obtained were compared to those already published for non-Jewish populations inhabiting the same countries and the differences in frequencies were not significant, with the exception of Lithuania (chi(2) = 2.20, p < 0.03). Founder effect and genetic drift are proposed to explain the elevated values observed in Ashkenazi Jews and those originating from Lithuania. IS - 4 JF - Genet Test SN - 1090-6576 AD - Center of Neurogenetics, Paris, France. Lucotte@hotmail.com EP - 337 TI - CCR5-Delta32 allele frequencies in Ashkenazi Jews. VL - 7 SP - 333 KW - ashkenazi KW - ccr5delta32 AU - Lucotte, G AU - Smets, P PY - 2003/// UR - http://dx.doi.org/10.1089/109065703322783716 ER -