The clonal evolution of tumor cell populations. Export

@article{citeulike:3171693, abstract = {It is proposed that most neoplasms arise from a single cell of origin, and tumor progression results from acquired genetic variability within the original clone allowing sequential selection of more aggressive sublines. Tumor cell populations are apparently more genetically unstable than normal cells, perhaps from activation of specific gene loci in the neoplasm, continued presence of carcinogen, or even nutritional deficiencies within the tumor. The acquired genetic insta0ility and associated selection process, most readily recognized cytogenetically, results in advanced human malignancies being highly individual karyotypically and biologically. Hence, each patient's cancer may require individual specific therapy, and even this may be thwarted by emergence of a genetically variant subline resistant to the treatment. More research should be directed toward understanding and controlling the evolutionary process in tumors before it reaches the late stage usually seen in clinical cancer.}, author = {Nowell, P. C.}, citeulike-article-id = {3171693}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.959840}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/194/4260/23}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/959840}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=959840}, day = {1}, doi = {10.1126/science.959840}, issn = {0036-8075}, journal = {Science (New York, N.Y.)}, keywords = {cancer\_evolution, clonal, evolution, historical, review, theory}, month = {October}, number = {4260}, pages = {23--28}, posted-at = {2009-03-26 21:40:09}, priority = {2}, title = {The clonal evolution of tumor cell populations.}, url = {http://dx.doi.org/10.1126/science.959840}, volume = {194}, year = {1976} }

TY - JOUR ID - citeulike:3171693 L3 - citeulike-article-id:3171693 N2 - It is proposed that most neoplasms arise from a single cell of origin, and tumor progression results from acquired genetic variability within the original clone allowing sequential selection of more aggressive sublines. Tumor cell populations are apparently more genetically unstable than normal cells, perhaps from activation of specific gene loci in the neoplasm, continued presence of carcinogen, or even nutritional deficiencies within the tumor. The acquired genetic insta0ility and associated selection process, most readily recognized cytogenetically, results in advanced human malignancies being highly individual karyotypically and biologically. Hence, each patient's cancer may require individual specific therapy, and even this may be thwarted by emergence of a genetically variant subline resistant to the treatment. More research should be directed toward understanding and controlling the evolutionary process in tumors before it reaches the late stage usually seen in clinical cancer. IS - 4260 JF - Science (New York, N.Y.) SN - 0036-8075 EP - 28 TI - The clonal evolution of tumor cell populations. VL - 194 SP - 23 KW - cancer_evolution KW - clonal KW - evolution KW - historical KW - review KW - theory AU - Nowell, PC PY - 1976/10/01/ UR - http://dx.doi.org/10.1126/science.959840 ER -