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Efficient mapping of Applied Biosystems SOLiD sequence data to a reference genome for functional genomic applications Export

Bioinformatics, Vol. 24, No. 23. (1 December 2008), pp. 2776-2777.

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abi_solid genomics mapping sequencing

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Summary: Here, we report the development of SOCS (short oligonucleotide color space), a program designed for efficient and flexible mapping of Applied Biosystems SOLiD sequence data onto a reference genome. SOCS performs its mapping within the context of color space', and it maximizes usable data by allowing a user-specified number of mismatches. Sequence census functions facilitate a variety of functional genomics applications, including transcriptome mapping and profiling, as well as ChIP-Seq. Availability: Executables, source code, and sample data are available at http://socs.biology.gatech.edu/ Contact: nickbergman@gatech.edu Supplementary information: Supplementary data are available at Bioinformatics Online. 10.1093/bioinformatics/btn512


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