The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer Export

@article{citeulike:5034497, abstract = {An inherited variant on chromosome 8q24, rs6983267, is significantly associated with cancer pathogenesis. We present evidence that the region harboring this variant is a transcriptional enhancer, that the alleles of rs6983267 differentially bind transcription factor 7-like 2 (TCF7L2) and that the risk region physically interacts with the MYC proto-oncogene. These data provide strong support for a biological mechanism underlying this non-protein-coding risk variant.}, author = {Pomerantz, Mark M. and Ahmadiyeh, Nasim and Jia, Li and Herman, Paula and Verzi, Michael P. and Doddapaneni, Harshavardhan and Beckwith, Christine A. and Chan, Jennifer A. and Hills, Adam and Davis, Matt and Yao, Keluo and Kehoe, Sarah M. and Lenz, Heinz-Josef and Haiman, Christopher A. and Yan, Chunli and Henderson, Brian E. and Frenkel, Baruch and Barretina, Jordi and Bass, Adam and Tabernero, Josep and Baselga, Jose and Regan, Meredith M. and Manak, J. Robert and Shivdasani, Ramesh and Coetzee, Gerhard A. and Freedman, Matthew L.}, citeulike-article-id = {5034497}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/ng.403}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/ng.403}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19561607}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19561607}, day = {28}, doi = {10.1038/ng.403}, issn = {1061-4036}, journal = {Nature Genetics}, keywords = {8q24, colon, myc, rs6983267}, month = {June}, number = {8}, pages = {882--884}, posted-at = {2009-07-01 17:16:06}, priority = {2}, publisher = {Nature Publishing Group}, title = {The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer}, url = {http://dx.doi.org/10.1038/ng.403}, volume = {41}, year = {2009} }

TY - JOUR ID - citeulike:5034497 L3 - citeulike-article-id:5034497 N2 - An inherited variant on chromosome 8q24, rs6983267, is significantly associated with cancer pathogenesis. We present evidence that the region harboring this variant is a transcriptional enhancer, that the alleles of rs6983267 differentially bind transcription factor 7-like 2 (TCF7L2) and that the risk region physically interacts with the MYC proto-oncogene. These data provide strong support for a biological mechanism underlying this non-protein-coding risk variant. IS - 8 JF - Nature Genetics SN - 1061-4036 EP - 884 TI - The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer PB - Nature Publishing Group VL - 41 SP - 882 KW - 8q24 KW - colon KW - myc KW - rs6983267 AU - Pomerantz, Mark AU - Ahmadiyeh, Nasim AU - Jia, Li AU - Herman, Paula AU - Verzi, Michael AU - Doddapaneni, Harshavardhan AU - Beckwith, Christine AU - Chan, Jennifer AU - Hills, Adam AU - Davis, Matt AU - Yao, Keluo AU - Kehoe, Sarah AU - Lenz, Heinz-Josef AU - Haiman, Christopher AU - Yan, Chunli AU - Henderson, Brian AU - Frenkel, Baruch AU - Barretina, Jordi AU - Bass, Adam AU - Tabernero, Josep AU - Baselga, Jose AU - Regan, Meredith AU - Manak, Robert AU - Shivdasani, Ramesh AU - Coetzee, Gerhard AU - Freedman, Matthew PY - 2009/06/28/ UR - http://dx.doi.org/10.1038/ng.403 ER -