Identification of seven new prostate cancer susceptibility loci through a genome-wide association study Export

@article{citeulike:5822077, abstract = {Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-wide association study in which 541,129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and in 1,894 controls. We have now extended the study to evaluate promising associations in a second stage in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls and in a third stage involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to replicating previous associations, we identified seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11 and 22 (with P = 1.6 10-8 to P = 2.7 10-33).}, author = {Eeles, Rosalind A. and Kote-Jarai, Zsofia and Al Olama, Ali A. and Giles, Graham G. and Guy, Michelle and Severi, Gianluca and Muir, Kenneth and Hopper, John L. and Henderson, Brian E. and Haiman, Christopher A. and Schleutker, Johanna and Hamdy, Freddie C. and Neal, David E. and Donovan, Jenny L. and Stanford, Janet L. and Ostrander, Elaine A. and Ingles, Sue A. and John, Esther M. and Thibodeau, Stephen N. and Schaid, Daniel and Park, Jong Y. and Spurdle, Amanda and Clements, Judith and Dickinson, Joanne L. and Maier, Christiane and Vogel, Walther and Dork, Thilo and Rebbeck, Timothy R. and Cooney, Kathleen A. and Cannon-Albright, Lisa and Chappuis, Pierre O. and Hutter, Pierre and Zeegers, Maurice and Kaneva, Radka and Zhang, Hong-Wei and Lu, Yong-Jie and Foulkes, William D. and English, Dallas R. and Leongamornlert, Daniel A. and Tymrakiewicz, Malgorzata and Morrison, Jonathan and Ardern-Jones, Audrey T. and Hall, Amanda L. and O'Brien, Lynne T. and Wilkinson, Rosemary A. and Saunders, Edward J. and Page, Elizabeth C. and Sawyer, Emma J. and Edwards, Stephen M. and Dearnaley, David P. and Horwich, Alan and Huddart, Robert A. and Khoo, Vincent S. and Parker, Christopher C. and Van As, Nicholas and Woodhouse, Christopher J. and Thompson, Alan and Christmas, Tim and Ogden, Chris and Cooper, Colin S. and Southey, Melissa C. and Lophatananon, Artitaya and Liu, Jo-Fen and Kolonel, Laurence N. and Le Marchand, Loic and Wahlfors, Tiina and Tammela, Teuvo L. and Auvinen, Anssi and Lewis, Sarah J. and Cox, Angela and FitzGerald, Liesel M. and Koopmeiners, Joseph S. and Karyadi, Danielle M. and Kwon, Erika M. and Stern, Mariana C. and Corral, Roman and Joshi, Amit D. and Shahabi, Ahva and McDonnell, Shannon K. and Sellers, Thomas A. and Pow-Sang, Julio and Chambers, Suzanne and Aitken, Joanne and Gardiner, R. A. Frank and Batra, Jyotsna and Kedda, Mary A. and Lose, Felicity and Polanowski, Andrea and Patterson, Briony and Serth, Jurgen and Meyer, Andreas and Luedeke, Manuel and Stefflova, Klara and Ray, Anna M. and Lange, Ethan M. and Farnham, Jim and Khan, Humera and Slavov, Chavdar and Mitkova, Atanaska and Cao, Guangwen and Easton, Douglas F.}, citeulike-article-id = {5822077}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/ng.450}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/ng.450}, day = {20}, doi = {10.1038/ng.450}, issn = {1061-4036}, journal = {Nature Genetics}, keywords = {gwas, prostate\_cancer}, month = {September}, number = {10}, pages = {1116--1121}, posted-at = {2009-09-22 18:00:09}, priority = {2}, publisher = {Nature Publishing Group}, title = {Identification of seven new prostate cancer susceptibility loci through a genome-wide association study}, url = {http://dx.doi.org/10.1038/ng.450}, volume = {41}, year = {2009} }

TY - JOUR ID - citeulike:5822077 L3 - citeulike-article-id:5822077 N2 - Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-wide association study in which 541,129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and in 1,894 controls. We have now extended the study to evaluate promising associations in a second stage in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls and in a third stage involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to replicating previous associations, we identified seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11 and 22 (with P = 1.6 10-8 to P = 2.7 10-33). IS - 10 JF - Nature Genetics SN - 1061-4036 EP - 1121 TI - Identification of seven new prostate cancer susceptibility loci through a genome-wide association study PB - Nature Publishing Group VL - 41 SP - 1116 KW - gwas KW - prostate_cancer AU - Eeles, Rosalind AU - Kote-Jarai, Zsofia AU - Al Olama, Ali AU - Giles, Graham AU - Guy, Michelle AU - Severi, Gianluca AU - Muir, Kenneth AU - Hopper, John AU - Henderson, Brian AU - Haiman, Christopher AU - Schleutker, Johanna AU - Hamdy, Freddie AU - Neal, David AU - Donovan, Jenny AU - Stanford, Janet AU - Ostrander, Elaine AU - Ingles, Sue AU - John, Esther AU - Thibodeau, Stephen AU - Schaid, Daniel AU - Park, Jong AU - Spurdle, Amanda AU - Clements, Judith AU - Dickinson, Joanne AU - Maier, Christiane AU - Vogel, Walther AU - Dork, Thilo AU - Rebbeck, Timothy AU - Cooney, Kathleen AU - Cannon-Albright, Lisa AU - Chappuis, Pierre AU - Hutter, Pierre AU - Zeegers, Maurice AU - Kaneva, Radka AU - Zhang, Hong-Wei AU - Lu, Yong-Jie AU - Foulkes, William AU - English, Dallas AU - Leongamornlert, Daniel AU - Tymrakiewicz, Malgorzata AU - Morrison, Jonathan AU - Ardern-Jones, Audrey AU - Hall, Amanda AU - O'Brien, Lynne AU - Wilkinson, Rosemary AU - Saunders, Edward AU - Page, Elizabeth AU - Sawyer, Emma AU - Edwards, Stephen AU - Dearnaley, David AU - Horwich, Alan AU - Huddart, Robert AU - Khoo, Vincent AU - Parker, Christopher AU - Van As, Nicholas AU - Woodhouse, Christopher AU - Thompson, Alan AU - Christmas, Tim AU - Ogden, Chris AU - Cooper, Colin AU - Southey, Melissa AU - Lophatananon, Artitaya AU - Liu, Jo-Fen AU - Kolonel, Laurence AU - Le Marchand, Loic AU - Wahlfors, Tiina AU - Tammela, Teuvo AU - Auvinen, Anssi AU - Lewis, Sarah AU - Cox, Angela AU - FitzGerald, Liesel AU - Koopmeiners, Joseph AU - Karyadi, Danielle AU - Kwon, Erika AU - Stern, Mariana AU - Corral, Roman AU - Joshi, Amit AU - Shahabi, Ahva AU - McDonnell, Shannon AU - Sellers, Thomas AU - Pow-Sang, Julio AU - Chambers, Suzanne AU - Aitken, Joanne AU - Gardiner, Frank AU - Batra, Jyotsna AU - Kedda, Mary AU - Lose, Felicity AU - Polanowski, Andrea AU - Patterson, Briony AU - Serth, Jurgen AU - Meyer, Andreas AU - Luedeke, Manuel AU - Stefflova, Klara AU - Ray, Anna AU - Lange, Ethan AU - Farnham, Jim AU - Khan, Humera AU - Slavov, Chavdar AU - Mitkova, Atanaska AU - Cao, Guangwen AU - Easton, Douglas PY - 2009/09/20/ UR - http://dx.doi.org/10.1038/ng.450 ER -