Quantitative trait loci predicting circulating sex steroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3) Export

@article{citeulike:5865601, abstract = {Twin studies suggest a heritable component to circulating sex steroid hormones and sex hormone-binding globulin (SHBG). In the NCI-Breast and Prostate Cancer Cohort Consortium, 874 SNPs in 37 candidate genes in the sex steroid hormone pathway were examined in relation to circulating levels of SHBG (N = 4720), testosterone (N = 4678), 3{alpha}-androstanediol-glucuronide (N = 4767) and 17{beta}-estradiol (N = 2014) in Caucasian men. rs1799941 in SHBG is highly significantly associated with circulating levels of SHBG (P = 4.52 x 10-21), consistent with previous studies, and testosterone (P = 7.54 x 10-15), with mean difference of 26.9 and 14.3\%, respectively, comparing wild-type to homozygous variant carriers. Further noteworthy novel findings were observed between SNPs in ESR1 with testosterone levels (rs722208, mean difference = 8.8\%, P = 7.37 x 10-6) and SRD5A2 with 3{alpha}-androstanediol-glucuronide (rs2208532, mean difference = 11.8\%, P = 1.82 x 10-6). Genetic variation in genes in the sex steroid hormone pathway is associated with differences in circulating SHBG and sex steroid hormones. 10.1093/hmg/ddp302}, author = {Ahn, Jiyoung and Schumacher, Fredrick R. and Berndt, Sonja I. and Pfeiffer, Ruth and Albanes, Demetrius and Andriole, Gerald L. and Ardanaz, Eva and Boeing, Heiner and Bueno-de-Mesquita, Bas and Chanock, Stephen J. and Clavel-Chapelon, Francoise and Diver, W. Ryan and Feigelson, Heather S. and Gaziano, J. Michael and Giovannucci, Edward and Haiman, Christopher A. and Henderson, Brian E. and Hoover, Robert N. and Kolonel, Laurence N. and Kraft, Peter and Ma, Jing and Le Marchand, Loic and Overvad, Kim and Palli, Domenico and Stattin, Par and Stampfer, Meir and Stram, Daniel O. and Thomas, Gilles and Thun, Michael J. and Travis, Ruth C. and Trichopoulos, Dimitrios and Virtamo, Jarmo and Weinstein, Stephanie J. and Yeager, Meredith and Kaaks, Rudolf and Hunter, David J. and Hayes, Richard B.}, citeulike-article-id = {5865601}, citeulike-linkout-0 = {http://dx.doi.org/10.1093/hmg/ddp302}, citeulike-linkout-1 = {http://hmg.oxfordjournals.org/content/18/19/3749.abstract}, citeulike-linkout-2 = {http://hmg.oxfordjournals.org/content/18/19/3749.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/19574343}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=19574343}, day = {1}, doi = {10.1093/hmg/ddp302}, journal = {Hum. Mol. Genet.}, keywords = {prostate, qtl, steroid, steroid\_hormone}, month = {October}, number = {19}, pages = {3749--3757}, posted-at = {2009-10-01 06:18:41}, priority = {2}, title = {Quantitative trait loci predicting circulating sex steroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3)}, url = {http://dx.doi.org/10.1093/hmg/ddp302}, volume = {18}, year = {2009} }

TY - JOUR ID - citeulike:5865601 L3 - citeulike-article-id:5865601 N2 - Twin studies suggest a heritable component to circulating sex steroid hormones and sex hormone-binding globulin (SHBG). In the NCI-Breast and Prostate Cancer Cohort Consortium, 874 SNPs in 37 candidate genes in the sex steroid hormone pathway were examined in relation to circulating levels of SHBG (N = 4720), testosterone (N = 4678), 3{alpha}-androstanediol-glucuronide (N = 4767) and 17{beta}-estradiol (N = 2014) in Caucasian men. rs1799941 in SHBG is highly significantly associated with circulating levels of SHBG (P = 4.52 x 10-21), consistent with previous studies, and testosterone (P = 7.54 x 10-15), with mean difference of 26.9 and 14.3%, respectively, comparing wild-type to homozygous variant carriers. Further noteworthy novel findings were observed between SNPs in ESR1 with testosterone levels (rs722208, mean difference = 8.8%, P = 7.37 x 10-6) and SRD5A2 with 3{alpha}-androstanediol-glucuronide (rs2208532, mean difference = 11.8%, P = 1.82 x 10-6). Genetic variation in genes in the sex steroid hormone pathway is associated with differences in circulating SHBG and sex steroid hormones. 10.1093/hmg/ddp302 IS - 19 JF - Hum. Mol. Genet. EP - 3757 TI - Quantitative trait loci predicting circulating sex steroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3) VL - 18 SP - 3749 KW - prostate KW - qtl KW - steroid KW - steroid_hormone AU - Ahn, Jiyoung AU - Schumacher, Fredrick AU - Berndt, Sonja AU - Pfeiffer, Ruth AU - Albanes, Demetrius AU - Andriole, Gerald AU - Ardanaz, Eva AU - Boeing, Heiner AU - Bueno-de-Mesquita, Bas AU - Chanock, Stephen AU - Clavel-Chapelon, Francoise AU - Diver, Ryan AU - Feigelson, Heather AU - Gaziano, Michael AU - Giovannucci, Edward AU - Haiman, Christopher AU - Henderson, Brian AU - Hoover, Robert AU - Kolonel, Laurence AU - Kraft, Peter AU - Ma, Jing AU - Le Marchand, Loic AU - Overvad, Kim AU - Palli, Domenico AU - Stattin, Par AU - Stampfer, Meir AU - Stram, Daniel AU - Thomas, Gilles AU - Thun, Michael AU - Travis, Ruth AU - Trichopoulos, Dimitrios AU - Virtamo, Jarmo AU - Weinstein, Stephanie AU - Yeager, Meredith AU - Kaaks, Rudolf AU - Hunter, David AU - Hayes, Richard PY - 2009/10/01/ UR - http://dx.doi.org/10.1093/hmg/ddp302 ER -