Prognostic significance of prostate cancer susceptibility variants on prostate-specific antigen recurrence after radical prostatectomy. Export

@article{citeulike:6102314, abstract = {Recent genomewide association studies have identified several prostate cancer susceptibility variants. However, the association between these variants and biochemical failure in prostate cancer patients receiving radical prostatectomy has not been determined. We systematically evaluated 20 prostate cancer-associated single-nucleotide polymorphisms in a cohort of 320 localized prostate cancer patients receiving radical prostatectomy. Each single-nucleotide polymorphism found to be associated with the recurrence of prostate-specific antigen was further analyzed by Kaplan-Meier analysis and Cox regression model. Three prostate cancer susceptibility single-nucleotide polymorphisms (rs1447295 at 8q24, rs7920517 and rs10993994 at 10q11) were associated with prostate-specific antigen recurrence (P < 0.02). Of these, rs7920517 and rs10993994, which were in strong linkage disequilibrium (r(2) = 0.91), also showed significant associations with poor prostate-specific antigen-free survival following radical prostatectomy (log-rank test; P < 0.01). The associations remained significant in our multivariate Cox proportional hazards analysis after adjusting for other clinicopathologic risk covariates (P < 0.01). In conclusion, loci associated with risk for prostate cancer, such as rs7920517 and rs10993994, might also be used to predict the recurrence of prostate-specific antigen in prostate cancer patients receiving radical prostatectomy. (Cancer Epidemiol Biomarkers Prev 2009;18(11):3068-74).}, author = {Huang, Shu-Pin P. and Huang, Li-Chia C. and Ting, Wen-Chien C. and Chen, Lu-Min M. and Chang, Ta-Yuan Y. and Lu, Te-Ling L. and Lan, Yu-Hsuan H. and Liu, Chia-Chu C. and Yang, Wen-Hui H. and Lee, Hong-Zin Z. and Hsieh, Chi-Jeng J. and Bao, Bo-Ying Y.}, citeulike-article-id = {6102314}, citeulike-linkout-0 = {http://dx.doi.org/10.1158/1055-9965.EPI-09-0665}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19900942}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19900942}, doi = {10.1158/1055-9965.EPI-09-0665}, issn = {1538-7755}, journal = {Cancer epidemiology, biomarkers \& prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology}, keywords = {10q11, 8q24, prognosis, prostatectomy, recurrence, rs10993994}, month = {November}, number = {11}, pages = {3068--3074}, posted-at = {2009-11-12 16:18:36}, priority = {2}, title = {Prognostic significance of prostate cancer susceptibility variants on prostate-specific antigen recurrence after radical prostatectomy.}, url = {http://dx.doi.org/10.1158/1055-9965.EPI-09-0665}, volume = {18}, year = {2009} }

TY - JOUR ID - citeulike:6102314 L3 - citeulike-article-id:6102314 N2 - Recent genomewide association studies have identified several prostate cancer susceptibility variants. However, the association between these variants and biochemical failure in prostate cancer patients receiving radical prostatectomy has not been determined. We systematically evaluated 20 prostate cancer-associated single-nucleotide polymorphisms in a cohort of 320 localized prostate cancer patients receiving radical prostatectomy. Each single-nucleotide polymorphism found to be associated with the recurrence of prostate-specific antigen was further analyzed by Kaplan-Meier analysis and Cox regression model. Three prostate cancer susceptibility single-nucleotide polymorphisms (rs1447295 at 8q24, rs7920517 and rs10993994 at 10q11) were associated with prostate-specific antigen recurrence (P < 0.02). Of these, rs7920517 and rs10993994, which were in strong linkage disequilibrium (r(2) = 0.91), also showed significant associations with poor prostate-specific antigen-free survival following radical prostatectomy (log-rank test; P < 0.01). The associations remained significant in our multivariate Cox proportional hazards analysis after adjusting for other clinicopathologic risk covariates (P < 0.01). In conclusion, loci associated with risk for prostate cancer, such as rs7920517 and rs10993994, might also be used to predict the recurrence of prostate-specific antigen in prostate cancer patients receiving radical prostatectomy. (Cancer Epidemiol Biomarkers Prev 2009;18(11):3068-74). IS - 11 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology SN - 1538-7755 EP - 3074 TI - Prognostic significance of prostate cancer susceptibility variants on prostate-specific antigen recurrence after radical prostatectomy. VL - 18 SP - 3068 KW - 10q11 KW - 8q24 KW - prognosis KW - prostatectomy KW - recurrence KW - rs10993994 AU - Huang, Shu-Pin AU - Huang, Li-Chia AU - Ting, Wen-Chien AU - Chen, Lu-Min AU - Chang, Ta-Yuan AU - Lu, Te-Ling AU - Lan, Yu-Hsuan AU - Liu, Chia-Chu AU - Yang, Wen-Hui AU - Lee, Hong-Zin AU - Hsieh, Chi-Jeng AU - Bao, Bo-Ying PY - 2009/11// UR - http://dx.doi.org/10.1158/1055-9965.EPI-09-0665 ER -