Resting-State Functional Connectivity in Major Depression: Abnormally Increased Contributions from Subgenual Cingulate Cortex and Thalamus. Export

@article{citeulike:1068754, abstract = {BACKGROUND: Positron emission tomography (PET) studies of major depression have revealed resting-state abnormalities in the prefrontal and cingulate cortices. Recently, fMRI has been adapted to examine connectivity within a specific resting-state neural network-the default-mode network-that includes medial prefrontal and anterior cingulate cortices. The goal of this study was to examine resting-state, default-mode network functional connectivity in subjects with major depression and in healthy controls. METHODS: Twenty-eight subjects with major depression and 20 healthy controls underwent 5-min fMRI scans while resting quietly. Independent component analysis was used to isolate the default-mode network in each subject. Group maps of the default-mode network were compared. A within-group analysis was performed in the depressed group to explore effects of depression refractoriness on functional connectivity. RESULTS: Resting-state subgenual cingulate and thalamic functional connectivity with the default-mode network were significantly greater in the depressed subjects. Within the depressed group, the length of the current depressive episode correlated positively with functional connectivity in the subgenual cingulate. CONCLUSIONS: This is the first study to explore default-mode functional connectivity in major depression. The findings provide cross-modality confirmation of PET studies demonstrating increased thalamic and subgenual cingulate activity in major depression. Further, the within-subject connectivity analysis employed here brings these previously isolated regions of hypermetabolism into the context of a disordered neural network. The correlation between refractoriness and subgenual cingulate functional connectivity within the network suggests that a quantitative, resting-state fMRI measure could be used to guide therapy in individual subjects.}, address = {Department of Neurology and Neurological Sciences; Department of Psychiatry and Behavioral Sciences.}, author = {Greicius, Michael D D. and Flores, Benjamin H H. and Menon, Vinod and Glover, Gary H H. and Solvason, Hugh B B. and Kenna, Heather and Reiss, Allan L L. and Schatzberg, Alan F F.}, citeulike-article-id = {1068754}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.biopsych.2006.09.020}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17210143}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17210143}, citeulike-linkout-3 = {http://www.sciencedirect.com/science/article/B6T4S-4MS9R7R-7/2/4c559c09c483995f5e6ab30c5ec6676c}, day = {6}, doi = {10.1016/j.biopsych.2006.09.020}, issn = {0006-3223}, journal = {Biol Psychiatry}, keywords = {default-mode, depression, ica, resting-state}, month = {January}, posted-at = {2007-01-26 10:02:07}, priority = {0}, title = {Resting-State Functional Connectivity in Major Depression: Abnormally Increased Contributions from Subgenual Cingulate Cortex and Thalamus.}, url = {http://dx.doi.org/10.1016/j.biopsych.2006.09.020}, year = {2007} }

TY - JOUR ID - citeulike:1068754 L3 - citeulike-article-id:1068754 N2 - BACKGROUND: Positron emission tomography (PET) studies of major depression have revealed resting-state abnormalities in the prefrontal and cingulate cortices. Recently, fMRI has been adapted to examine connectivity within a specific resting-state neural network-the default-mode network-that includes medial prefrontal and anterior cingulate cortices. The goal of this study was to examine resting-state, default-mode network functional connectivity in subjects with major depression and in healthy controls. METHODS: Twenty-eight subjects with major depression and 20 healthy controls underwent 5-min fMRI scans while resting quietly. Independent component analysis was used to isolate the default-mode network in each subject. Group maps of the default-mode network were compared. A within-group analysis was performed in the depressed group to explore effects of depression refractoriness on functional connectivity. RESULTS: Resting-state subgenual cingulate and thalamic functional connectivity with the default-mode network were significantly greater in the depressed subjects. Within the depressed group, the length of the current depressive episode correlated positively with functional connectivity in the subgenual cingulate. CONCLUSIONS: This is the first study to explore default-mode functional connectivity in major depression. The findings provide cross-modality confirmation of PET studies demonstrating increased thalamic and subgenual cingulate activity in major depression. Further, the within-subject connectivity analysis employed here brings these previously isolated regions of hypermetabolism into the context of a disordered neural network. The correlation between refractoriness and subgenual cingulate functional connectivity within the network suggests that a quantitative, resting-state fMRI measure could be used to guide therapy in individual subjects. JF - Biol Psychiatry SN - 0006-3223 AD - Department of Neurology and Neurological Sciences; Department of Psychiatry and Behavioral Sciences. TI - Resting-State Functional Connectivity in Major Depression: Abnormally Increased Contributions from Subgenual Cingulate Cortex and Thalamus. KW - default-mode KW - depression KW - ica KW - resting-state AU - Greicius, Michael D AU - Flores, Benjamin H AU - Menon, Vinod AU - Glover, Gary H AU - Solvason, Hugh B AU - Kenna, Heather AU - Reiss, Allan L AU - Schatzberg, Alan F PY - 2007/01/06/ UR - http://dx.doi.org/10.1016/j.biopsych.2006.09.020 ER -