Dissociable Intrinsic Connectivity Networks for Salience Processing and Executive Control Export

@article{citeulike:1178601, abstract = {Variations in neural circuitry, inherited or acquired, may underlie important individual differences in thought, feeling, and action patterns. Here, we used task-free connectivity analyses to isolate and characterize two distinct networks typically coactivated during functional MRI tasks. We identified a "salience network," anchored by dorsal anterior cingulate (dACC) and orbital frontoinsular cortices with robust connectivity to subcortical and limbic structures, and an "executive-control network" that links dorsolateral frontal and parietal neocortices. These intrinsic connectivity networks showed dissociable correlations with functions measured outside the scanner. Prescan anxiety ratings correlated with intrinsic functional connectivity of the dACC node of the salience network, but with no region in the executive-control network, whereas executive task performance correlated with lateral parietal nodes of the executive-control network, but with no region in the salience network. Our findings suggest that task-free analysis of intrinsic connectivity networks may help elucidate the neural architectures that support fundamental aspects of human behavior. 10.1523/JNEUROSCI.5587-06.2007}, author = {Seeley, William W. and Menon, Vinod and Schatzberg, Alan F. and Keller, Jennifer and Glover, Gary H. and Kenna, Heather and Reiss, Allan L. and Greicius, Michael D.}, citeulike-article-id = {1178601}, citeulike-linkout-0 = {http://dx.doi.org/10.1523/JNEUROSCI.5587}, citeulike-linkout-1 = {http://www.jneurosci.org/cgi/content/abstract/27/9/2349}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17329432}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17329432}, day = {28}, doi = {10.1523/JNEUROSCI.5587}, journal = {J. Neurosci.}, keywords = {fmri, functional-connectivity, ica}, month = {February}, number = {9}, pages = {2349--2356}, posted-at = {2007-05-01 06:05:06}, priority = {0}, title = {Dissociable Intrinsic Connectivity Networks for Salience Processing and Executive Control}, url = {http://dx.doi.org/10.1523/JNEUROSCI.5587}, volume = {27}, year = {2007} }

TY - JOUR ID - citeulike:1178601 L3 - citeulike-article-id:1178601 N2 - Variations in neural circuitry, inherited or acquired, may underlie important individual differences in thought, feeling, and action patterns. Here, we used task-free connectivity analyses to isolate and characterize two distinct networks typically coactivated during functional MRI tasks. We identified a "salience network," anchored by dorsal anterior cingulate (dACC) and orbital frontoinsular cortices with robust connectivity to subcortical and limbic structures, and an "executive-control network" that links dorsolateral frontal and parietal neocortices. These intrinsic connectivity networks showed dissociable correlations with functions measured outside the scanner. Prescan anxiety ratings correlated with intrinsic functional connectivity of the dACC node of the salience network, but with no region in the executive-control network, whereas executive task performance correlated with lateral parietal nodes of the executive-control network, but with no region in the salience network. Our findings suggest that task-free analysis of intrinsic connectivity networks may help elucidate the neural architectures that support fundamental aspects of human behavior. 10.1523/JNEUROSCI.5587-06.2007 IS - 9 JF - J. Neurosci. EP - 2356 TI - Dissociable Intrinsic Connectivity Networks for Salience Processing and Executive Control VL - 27 SP - 2349 KW - fmri KW - functional-connectivity KW - ica AU - Seeley, William AU - Menon, Vinod AU - Schatzberg, Alan AU - Keller, Jennifer AU - Glover, Gary AU - Kenna, Heather AU - Reiss, Allan AU - Greicius, Michael PY - 2007/02/28/ UR - http://dx.doi.org/10.1523/JNEUROSCI.5587 ER -