Cingulate-Precuneus Interactions: A New Locus of Dysfunction in Adult Attention-Deficit/Hyperactivity Disorder. Export

@article{citeulike:1703333, abstract = {BACKGROUND: Pathophysiologic models of attention-deficit/hyperactivity disorder (ADHD) have focused on frontal-striatal circuitry with alternative hypotheses relatively unexplored. On the basis of evidence that negative interactions between frontal foci involved in cognitive control and the non-goal-directed "default-mode" network prevent attentional lapses, we hypothesized abnormalities in functional connectivity of these circuits in ADHD. METHODS: Resting-state blood oxygen level-dependent functional magnetic resonance imaging (fMRI) scans were obtained at 3.0-Tesla in 20 adults with ADHD and 20 age- and sex-matched healthy volunteers. RESULTS: Examination of healthy control subjects verified presence of an antiphasic or negative relationship between activity in dorsal anterior cingulate cortex (centered at x = 8, y = 7, z = 38) and in default-mode network components. Group analyses revealed ADHD-related compromises in this relationship, with decreases in the functional connectivity between the anterior cingulate and precuneus/posterior cingulate cortex regions (p < .0004, corrected). Secondary analyses revealed an extensive pattern of ADHD-related decreases in connectivity between precuneus and other default-mode network components, including ventromedial prefrontal cortex (p < 3 x 10(-11), corrected) and portions of posterior cingulate (p < .02, corrected). CONCLUSIONS: Together with prior unbiased anatomic evidence of posterior volumetric abnormalities, our findings suggest that the long-range connections linking dorsal anterior cingulate to posterior cingulate and precuneus should be considered as a candidate locus of dysfunction in ADHD.}, address = {Phyllis Green and Randolph Cōwen Institute for Pediatric NeuroscienceNew York University Child Study Center; Nathan Kline Institute for Psychiatric ResearchOrangeburg, New York.}, author = {Castellanos, F Xavier X. and Margulies, Daniel S S. and Kelly, Clare and Uddin, Lucina Q Q. and Ghaffari, Manely and Kirsch, Andrew and Shaw, David and Shehzad, Zarrar and Di Martino, Adriana and Biswal, Bharat and Sonuga-Barke, Edmund J S J. and Rotrosen, John and Adler, Lenard A A. and Milham, Michael P P.}, citeulike-article-id = {1703333}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.biopsych.2007.06.025}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17888409}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17888409}, citeulike-linkout-3 = {http://www.scopus.com/record/display.url?view=extended&origin=resultslist&eid=2-s2.0-38049078773}, citeulike-linkout-4 = {http://www.sciencedirect.com/science/article/B6T4S-4PPWMGT-3/2/e6758a8298111fb2a151787194fada83}, day = {20}, doi = {10.1016/j.biopsych.2007.06.025}, issn = {0006-3223}, journal = {Biol Psychiatry}, keywords = {adhd, attention-system, cingulate}, month = {September}, posted-at = {2007-09-28 01:35:38}, priority = {5}, title = {Cingulate-Precuneus Interactions: A New Locus of Dysfunction in Adult Attention-Deficit/Hyperactivity Disorder.}, url = {http://dx.doi.org/10.1016/j.biopsych.2007.06.025}, year = {2007} }

TY - JOUR ID - citeulike:1703333 L3 - citeulike-article-id:1703333 N2 - BACKGROUND: Pathophysiologic models of attention-deficit/hyperactivity disorder (ADHD) have focused on frontal-striatal circuitry with alternative hypotheses relatively unexplored. On the basis of evidence that negative interactions between frontal foci involved in cognitive control and the non-goal-directed "default-mode" network prevent attentional lapses, we hypothesized abnormalities in functional connectivity of these circuits in ADHD. METHODS: Resting-state blood oxygen level-dependent functional magnetic resonance imaging (fMRI) scans were obtained at 3.0-Tesla in 20 adults with ADHD and 20 age- and sex-matched healthy volunteers. RESULTS: Examination of healthy control subjects verified presence of an antiphasic or negative relationship between activity in dorsal anterior cingulate cortex (centered at x = 8, y = 7, z = 38) and in default-mode network components. Group analyses revealed ADHD-related compromises in this relationship, with decreases in the functional connectivity between the anterior cingulate and precuneus/posterior cingulate cortex regions (p < .0004, corrected). Secondary analyses revealed an extensive pattern of ADHD-related decreases in connectivity between precuneus and other default-mode network components, including ventromedial prefrontal cortex (p < 3 x 10(-11), corrected) and portions of posterior cingulate (p < .02, corrected). CONCLUSIONS: Together with prior unbiased anatomic evidence of posterior volumetric abnormalities, our findings suggest that the long-range connections linking dorsal anterior cingulate to posterior cingulate and precuneus should be considered as a candidate locus of dysfunction in ADHD. JF - Biol Psychiatry SN - 0006-3223 AD - Phyllis Green and Randolph Cōwen Institute for Pediatric NeuroscienceNew York University Child Study Center; Nathan Kline Institute for Psychiatric ResearchOrangeburg, New York. TI - Cingulate-Precuneus Interactions: A New Locus of Dysfunction in Adult Attention-Deficit/Hyperactivity Disorder. KW - adhd KW - attention-system KW - cingulate AU - Castellanos, F Xavier AU - Margulies, Daniel S AU - Kelly, Clare AU - Uddin, Lucina Q AU - Ghaffari, Manely AU - Kirsch, Andrew AU - Shaw, David AU - Shehzad, Zarrar AU - Di Martino, Adriana AU - Biswal, Bharat AU - Sonuga-Barke, Edmund J S AU - Rotrosen, John AU - Adler, Lenard A AU - Milham, Michael P PY - 2007/09/20/ UR - http://dx.doi.org/10.1016/j.biopsych.2007.06.025 ER -