Altered resting state networks in mild cognitive impairment and mild Alzheimer's disease: An fMRI study Export

@article{citeulike:677819, abstract = {Activity and reactivity of the default mode network in the brain was studied using functional magnetic resonance imaging (fMRI) in 28 nondemented individuals with mild cognitive impairment (MCI), 18 patients with mild Alzheimer's disease (AD), and 41 healthy elderly controls (HC). The default mode network was interrogated by means of decreases in brain activity, termed deactivations, during a visual encoding task and during a nonspatial working memory task. Deactivation was found in the default mode network involving the anterior frontal, precuneus, and posterior cingulate cortex. MCI patients showed less deactivation than HC, but more than AD. The most pronounced differences between MCI, HC, and AD occurred in the very early phase of deactivation, reflecting the reactivity and adaptation of the network. The default mode network response in the anterior frontal cortex significantly distinguished MCI from both HC (in the medial frontal) and AD (in the anterior cingulate cortex). The response in the precuneus could only distinguish between patients and HC, not between MCI and AD. These findings may be consistent with the notion that MCI is a transitional state between healthy aging and dementia and with the proposed early changes in MCI in the posterior cingulate cortex and precuneus. These findings suggest that altered activity in the default mode network may act as an early marker for AD pathology. Hum Brain Mapp, 2005. {\copyright} 2005 Wiley-Liss, Inc.}, address = {Department of Physics \& Medical Technology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands; Department of Radiology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands; Department of Neurology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands; Department of Clinical Neurophysiology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands}, author = {Rombouts, Serge A. R. B. and Barkhof, Frederik and Goekoop, Rutger and Stam, Cornelis J. and Scheltens, Philip}, citeulike-article-id = {677819}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/hbm.20160}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15954139}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15954139}, citeulike-linkout-3 = {http://www3.interscience.wiley.com/cgi-bin/abstract/110531804/ABSTRACT}, doi = {10.1002/hbm.20160}, journal = {Human Brain Mapping}, keywords = {alzheimer, resting-state}, number = {4}, pages = {231--239}, posted-at = {2006-10-14 07:23:02}, priority = {3}, title = {Altered resting state networks in mild cognitive impairment and mild Alzheimer's disease: An fMRI study}, url = {http://dx.doi.org/10.1002/hbm.20160}, volume = {26}, year = {2005} }

TY - JOUR ID - citeulike:677819 L3 - citeulike-article-id:677819 N2 - Activity and reactivity of the default mode network in the brain was studied using functional magnetic resonance imaging (fMRI) in 28 nondemented individuals with mild cognitive impairment (MCI), 18 patients with mild Alzheimer's disease (AD), and 41 healthy elderly controls (HC). The default mode network was interrogated by means of decreases in brain activity, termed deactivations, during a visual encoding task and during a nonspatial working memory task. Deactivation was found in the default mode network involving the anterior frontal, precuneus, and posterior cingulate cortex. MCI patients showed less deactivation than HC, but more than AD. The most pronounced differences between MCI, HC, and AD occurred in the very early phase of deactivation, reflecting the reactivity and adaptation of the network. The default mode network response in the anterior frontal cortex significantly distinguished MCI from both HC (in the medial frontal) and AD (in the anterior cingulate cortex). The response in the precuneus could only distinguish between patients and HC, not between MCI and AD. These findings may be consistent with the notion that MCI is a transitional state between healthy aging and dementia and with the proposed early changes in MCI in the posterior cingulate cortex and precuneus. These findings suggest that altered activity in the default mode network may act as an early marker for AD pathology. Hum Brain Mapp, 2005. © 2005 Wiley-Liss, Inc. IS - 4 JF - Human Brain Mapping AD - Department of Physics & Medical Technology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands; Department of Radiology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands; Department of Neurology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands; Department of Clinical Neurophysiology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands EP - 239 TI - Altered resting state networks in mild cognitive impairment and mild Alzheimer's disease: An fMRI study VL - 26 SP - 231 KW - alzheimer KW - resting-state AU - Rombouts, Serge AU - Barkhof, Frederik AU - Goekoop, Rutger AU - Stam, Cornelis AU - Scheltens, Philip PY - 2005/// UR - http://dx.doi.org/10.1002/hbm.20160 ER -