Vascular dynamics and BOLD fMRI: CBF level effects and analysis considerations. Export

@article{citeulike:866512, abstract = {Changes in the cerebral blood flow (CBF) baseline produce significant changes to the hemodynamic response. This work shows that increases in the baseline blood flow level produce blood oxygenation-level dependent (BOLD) and blood flow responses that are slower and lower in amplitude, while decreases in the baseline blood flow level produce faster and higher amplitude hemodynamic responses. This effect was characterized using a vascular model of the hemodynamic response that separated arterial blood flow response from the venous blood volume response and linked the input stimulus to the vascular response. The model predicted the baseline blood flow level effects to be dominated by changes in the arterial vasculature. Specifically, it predicted changes in the arterial blood flow time constant and venous blood volume time constant parameters of +294\% and -24\%, respectively, for a 27\% increase in the baseline blood flow. The vascular model performance was compared to an empirical model of the hemodynamic response. The vascular and empirical hemodynamic models captured most of the baseline blood flow level effects observed and can be used to correct for these effects in fMRI data. While the empirical hemodynamic model is easy to implement, it did not incorporate any explicit physiological information.}, address = {Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.}, author = {Vazquez, A. L. and Cohen, E. R. and Gulani, V. and Hernandez-Garcia, L. and Zheng, Y. and Lee, G. R. and Kim, S. G. and Grotberg, J. B. and Noll, D. C.}, citeulike-article-id = {866512}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.neuroimage.2006.04.195}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16860574}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16860574}, day = {1}, doi = {10.1016/j.neuroimage.2006.04.195}, issn = {1053-8119}, journal = {Neuroimage}, keywords = {bold, cbf, resting-state}, month = {October}, number = {4}, pages = {1642--1655}, posted-at = {2006-09-24 07:33:52}, priority = {2}, title = {Vascular dynamics and BOLD fMRI: CBF level effects and analysis considerations.}, url = {http://dx.doi.org/10.1016/j.neuroimage.2006.04.195}, volume = {32}, year = {2006} }

TY - JOUR ID - citeulike:866512 L3 - citeulike-article-id:866512 N2 - Changes in the cerebral blood flow (CBF) baseline produce significant changes to the hemodynamic response. This work shows that increases in the baseline blood flow level produce blood oxygenation-level dependent (BOLD) and blood flow responses that are slower and lower in amplitude, while decreases in the baseline blood flow level produce faster and higher amplitude hemodynamic responses. This effect was characterized using a vascular model of the hemodynamic response that separated arterial blood flow response from the venous blood volume response and linked the input stimulus to the vascular response. The model predicted the baseline blood flow level effects to be dominated by changes in the arterial vasculature. Specifically, it predicted changes in the arterial blood flow time constant and venous blood volume time constant parameters of +294% and -24%, respectively, for a 27% increase in the baseline blood flow. The vascular model performance was compared to an empirical model of the hemodynamic response. The vascular and empirical hemodynamic models captured most of the baseline blood flow level effects observed and can be used to correct for these effects in fMRI data. While the empirical hemodynamic model is easy to implement, it did not incorporate any explicit physiological information. IS - 4 JF - Neuroimage SN - 1053-8119 AD - Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA. EP - 1655 TI - Vascular dynamics and BOLD fMRI: CBF level effects and analysis considerations. VL - 32 SP - 1642 KW - bold KW - cbf KW - resting-state AU - Vazquez, AL AU - Cohen, ER AU - Gulani, V AU - Hernandez-Garcia, L AU - Zheng, Y AU - Lee, GR AU - Kim, SG AU - Grotberg, JB AU - Noll, DC PY - 2006/10/01/ UR - http://dx.doi.org/10.1016/j.neuroimage.2006.04.195 ER -