Transverse relaxation of cells labeled with magnetic nanoparticles

@article{citeulike:1206394, abstract = {We describe the NMR relaxation properties of magnetically labeled cells. The cells are labeled with magnetic nanoparticles (SPIO, USPIO), which generate susceptibility contrast. The geometry of the labeled cells and the surrounding tissue is considered. We assume that the magnetic nanoparticles accumulate to form a magnetic core of radius RC inside the cell. The correlation time ?, which describes the motion of spins around this core, is analyzed. Using the strong collision approach, explicit expressions are derived for the transverse relaxation rate R2* for tissue containing labeled cells as a function of the core radius, the diffusion coefficient, and the concentration of the nanoparticles. The predictions of this model agree well with numerical simulations and experimental data. Magn Reson Med, 2005. {\copyright} 2005 Wiley-Liss, Inc.}, address = {Bayerische Julius-Maximilians-Universit\"{a}t W\"{u}rzburg, Institut f\"{u}r Experimentelle Physik 5, Am Hubland, 97074 W\"{u}rzburg, Germany; Bayerische Julius-Maximilians-Universit\"{a}t W\"{u}rzburg, Medizinische Universit\"{a}tsklinik, Josef-Schneider-Strasse 2, 97080 W\"{u}rzburg, Germany}, author = {Ziener, C. H. and Bauer, W. R. and Jakob, P. M. }, citeulike-article-id = {1206394}, doi = {10.1002/mrm.20634}, journal = {Magnetic Resonance in Medicine}, keywords = {mri, nanoparticles, relaxation}, number = {3}, pages = {702--706}, posted-at = {2007-04-04 17:07:12}, priority = {5}, title = {Transverse relaxation of cells labeled with magnetic nanoparticles}, url = {http://dx.doi.org/10.1002/mrm.20634}, volume = {54}, year = {2005} }

TY - JOUR ID - citeulike:1206394 L3 - citeulike-article-id:1206394 TI - Transverse relaxation of cells labeled with magnetic nanoparticles JF - Magnetic Resonance in Medicine VL - 54 IS - 3 SP - 702 EP - 706 AD - Bayerische Julius-Maximilians-Universität Würzburg, Institut für Experimentelle Physik 5, Am Hubland, 97074 Würzburg, Germany; Bayerische Julius-Maximilians-Universität Würzburg, Medizinische Universitätsklinik, Josef-Schneider-Strasse 2, 97080 Würzburg, Germany N2 - We describe the NMR relaxation properties of magnetically labeled cells. The cells are labeled with magnetic nanoparticles (SPIO, USPIO), which generate susceptibility contrast. The geometry of the labeled cells and the surrounding tissue is considered. We assume that the magnetic nanoparticles accumulate to form a magnetic core of radius RC inside the cell. The correlation time ?, which describes the motion of spins around this core, is analyzed. Using the strong collision approach, explicit expressions are derived for the transverse relaxation rate R2* for tissue containing labeled cells as a function of the core radius, the diffusion coefficient, and the concentration of the nanoparticles. The predictions of this model agree well with numerical simulations and experimental data. Magn Reson Med, 2005. © 2005 Wiley-Liss, Inc. KW - mri KW - nanoparticles KW - relaxation AU - Ziener, CH AU - Bauer, WR AU - Jakob, PM PY - 2005/// UR - http://dx.doi.org/10.1002/mrm.20634 ER -