Impact of stroma on the growth, microcirculation, and metabolism of experimental prostate tumors. Export

@article{citeulike:1689305, abstract = {In prostate cancers (PCa), the formation of malignant stroma may substantially influence tumor phenotype and aggressiveness. Thus, the impact of the orthotopic and subcutaneous implantations of hormone-sensitive (H), hormone-insensitive (HI), and anaplastic (AT1) Dunning PCa in rats on growth, microcirculation, and metabolism was investigated. For this purpose, dynamic contrast-enhanced magnetic resonance imaging and (1)H magnetic resonance spectroscopy ([(1)H]MRS) were applied in combination with histology. Consistent observations revealed that orthotopic H tumors grew significantly slower compared to subcutaneous ones, whereas the growth of HI and AT1 tumors was comparable at both locations. Histologic analysis indicated that glandular differentiation and a close interaction of tumor cells and smooth muscle cells (SMC) were associated with slow tumor growth. Furthermore, there was a significantly lower SMC density in subcutaneous H tumors than in orthotopic H tumors. Perfusion was observed to be significantly lower in orthotopic H tumors than in subcutaneous H tumors. Regional blood volume and permeability-surface area product showed no significant differences between tumor models and their implantation sites. Differences in growth between subcutaneous and orthotopic H tumors can be attributed to tumor-stroma interaction and perfusion. Here, SMC, may stabilize glandular structures and contribute to the maintenance of differentiated phenotype.}, address = {Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.}, author = {Zechmann, C. M. and Woenne, E. C. and Brix, G. and Radzwill, N. and Ilg, M. and Bachert, P. and Peschke, P. and Kirsch, S. and Kauczor, H. U. and Delorme, S. and Semmler, W. and Kiessling, F.}, citeulike-article-id = {1689305}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/17325744}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=17325744}, issn = {1476-5586}, journal = {Neoplasia}, keywords = {cancer, prostate, rodent, tumor}, month = {January}, number = {1}, pages = {57--67}, posted-at = {2007-09-24 12:49:50}, priority = {5}, title = {Impact of stroma on the growth, microcirculation, and metabolism of experimental prostate tumors.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/17325744}, volume = {9}, year = {2007} }

TY - JOUR ID - citeulike:1689305 L3 - citeulike-article-id:1689305 N2 - In prostate cancers (PCa), the formation of malignant stroma may substantially influence tumor phenotype and aggressiveness. Thus, the impact of the orthotopic and subcutaneous implantations of hormone-sensitive (H), hormone-insensitive (HI), and anaplastic (AT1) Dunning PCa in rats on growth, microcirculation, and metabolism was investigated. For this purpose, dynamic contrast-enhanced magnetic resonance imaging and (1)H magnetic resonance spectroscopy ([(1)H]MRS) were applied in combination with histology. Consistent observations revealed that orthotopic H tumors grew significantly slower compared to subcutaneous ones, whereas the growth of HI and AT1 tumors was comparable at both locations. Histologic analysis indicated that glandular differentiation and a close interaction of tumor cells and smooth muscle cells (SMC) were associated with slow tumor growth. Furthermore, there was a significantly lower SMC density in subcutaneous H tumors than in orthotopic H tumors. Perfusion was observed to be significantly lower in orthotopic H tumors than in subcutaneous H tumors. Regional blood volume and permeability-surface area product showed no significant differences between tumor models and their implantation sites. Differences in growth between subcutaneous and orthotopic H tumors can be attributed to tumor-stroma interaction and perfusion. Here, SMC, may stabilize glandular structures and contribute to the maintenance of differentiated phenotype. IS - 1 JF - Neoplasia SN - 1476-5586 AD - Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. EP - 67 TI - Impact of stroma on the growth, microcirculation, and metabolism of experimental prostate tumors. VL - 9 SP - 57 KW - cancer KW - prostate KW - rodent KW - tumor AU - Zechmann, CM AU - Woenne, EC AU - Brix, G AU - Radzwill, N AU - Ilg, M AU - Bachert, P AU - Peschke, P AU - Kirsch, S AU - Kauczor, HU AU - Delorme, S AU - Semmler, W AU - Kiessling, F PY - 2007/01// UR - http://view.ncbi.nlm.nih.gov/pubmed/17325744 ER -