Multiparametric differentiation of posterior fossa tumors in children using diffusion-weighted imaging and short echo-time <SUP><FONT SIZE='-1'>1</FONT></SUP>H-MR spectroscopy Export

@article{citeulike:1959335, abstract = {To assess the combined value of diffusion-weighted imaging (DWI) and proton magnetic resonance spectroscopy (1H-MRS) in differentiating medulloblastoma, ependymoma, pilocytic astrocytoma, and infiltrating glioma in a pediatric population.A total of 17 children with untreated posterior fossa tumors (seven medulloblastoma, four infiltrating glioma, two ependymoma, and four pilocytic astrocytoma), were investigated with conventional MRI, DWI, and MRS using a single-voxel technique. Within the nonnecrotic tumor core, apparent diffusion coefficient (ADC) values using a standardized region of interest (ROI) were retrieved. Quantification of water signal and analysis of metabolite signals from MRS measurements in the same tumorous area were reviewed using multivariant linear discriminant analysis.Combination of ADC values and metabolites, which were normalized using water as an internal standard, allowed discrimination between the four tumor groups with a likelihood below 1 × 10-9. Positive predictive value was 1 in all cases. Tumors could not be discriminated when using metabolite ratios or ADC values alone, nor could they be differentiated using creatine (Cr) as an internal reference even in combination with ADC values.Linear discriminant analysis using DWI and MRS using water as internal reference, fully discriminates the four most frequent posterior fossa tumors in children. J. Magn. Reson. Imaging. {\copyright} 2007 Wiley-Liss, Inc.}, address = {Centre de R\'{e}sonance Magn\'{e}tique Biologique et M\'{e}dicale, Unit\'{e} Mixte de Recherche-Centre National de la Recherche Scientifique (UMR-CNRS) 6612, Facult\'{e} de M\'{e}decine, Universit\'{e} de la M\'{e}diterran\'{e}e, Marseille, France; Department of Neuroradiology, H\^{o}pital la Timone, Universit\'{e} de la M\'{e}diterran\'{e}e, Marseille, France; Department of Pathology and Neuropathology, H\^{o}pital la Timone, Universit\'{e} de la M\'{e}diterran\'{e}e, Marseille, France; Department of Pediatric Radiology, University Children's Hospital Universit\"{a}ts Kinderspital beider Basel (UKBB), Basel, Switzerland}, author = {Schneider, J. F. and Confort-Gouny, S. and Viola, A. and Le Fur, Y. and Viout, P. and Bennathan, M. and Chapon, F. and Figarella-Branger, D. and Cozzone, P. and Girard, N.}, citeulike-article-id = {1959335}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/jmri.21185}, citeulike-linkout-1 = {http://www3.interscience.wiley.com/cgi-bin/abstract/116835673/ABSTRACT}, doi = {10.1002/jmri.21185}, journal = {Journal of Magnetic Resonance Imaging}, keywords = {cancer, dw-mri, mr-spectro}, number = {9999}, pages = {NA+}, posted-at = {2007-11-22 14:02:54}, priority = {5}, title = {Multiparametric differentiation of posterior fossa tumors in children using diffusion-weighted imaging and short echo-time <SUP><FONT SIZE='-1'>1</FONT></SUP>H-MR spectroscopy}, url = {http://dx.doi.org/10.1002/jmri.21185}, volume = {9999}, year = {2007} }

TY - JOUR ID - citeulike:1959335 L3 - citeulike-article-id:1959335 N2 - To assess the combined value of diffusion-weighted imaging (DWI) and proton magnetic resonance spectroscopy (1H-MRS) in differentiating medulloblastoma, ependymoma, pilocytic astrocytoma, and infiltrating glioma in a pediatric population.A total of 17 children with untreated posterior fossa tumors (seven medulloblastoma, four infiltrating glioma, two ependymoma, and four pilocytic astrocytoma), were investigated with conventional MRI, DWI, and MRS using a single-voxel technique. Within the nonnecrotic tumor core, apparent diffusion coefficient (ADC) values using a standardized region of interest (ROI) were retrieved. Quantification of water signal and analysis of metabolite signals from MRS measurements in the same tumorous area were reviewed using multivariant linear discriminant analysis.Combination of ADC values and metabolites, which were normalized using water as an internal standard, allowed discrimination between the four tumor groups with a likelihood below 1 × 10-9. Positive predictive value was 1 in all cases. Tumors could not be discriminated when using metabolite ratios or ADC values alone, nor could they be differentiated using creatine (Cr) as an internal reference even in combination with ADC values.Linear discriminant analysis using DWI and MRS using water as internal reference, fully discriminates the four most frequent posterior fossa tumors in children. J. Magn. Reson. Imaging. © 2007 Wiley-Liss, Inc. IS - 9999 JF - Journal of Magnetic Resonance Imaging AD - Centre de Résonance Magnétique Biologique et Médicale, Unité Mixte de Recherche-Centre National de la Recherche Scientifique (UMR-CNRS) 6612, Faculté de Médecine, Université de la Méditerranée, Marseille, France; Department of Neuroradiology, Hôpital la Timone, Université de la Méditerranée, Marseille, France; Department of Pathology and Neuropathology, Hôpital la Timone, Université de la Méditerranée, Marseille, France; Department of Pediatric Radiology, University Children's Hospital Universitäts Kinderspital beider Basel (UKBB), Basel, Switzerland TI - Multiparametric differentiation of posterior fossa tumors in children using diffusion-weighted imaging and short echo-time <SUP><FONT SIZE='-1'>1</FONT></SUP>H-MR spectroscopy VL - 9999 SP - NA KW - cancer KW - dw-mri KW - mr-spectro AU - Schneider, JF AU - Confort-Gouny, S AU - Viola, A AU - Le Fur, Y AU - Viout, P AU - Bennathan, M AU - Chapon, F AU - Figarella-Branger, D AU - Cozzone, P AU - Girard, N PY - 2007/// UR - http://dx.doi.org/10.1002/jmri.21185 ER -