Apparent diffusion coefficients in oligodendroglial tumors characterized by genotype

@article{citeulike:2066084, abstract = {To investigate whether oligodendroglial tumors with or without 1p/19q loss differ in their diffusion-weighted imaging characteristics. Oligodendroglial tumors with or without 1p/19q loss differ in their therapeutic responsiveness and prognosis, and recent reports also suggest that these tumors may differ in their magnetic resonance characteristics and blood volume.Apparent diffusion coefficients (ADCs) were assessed in three grade II oligodendrogliomas, nine grade II and five grade III oligoastrocytomas with known 1p/19q status. Regions of interest (ROIs) were placed on ADC maps: 1) around tumor margins to generate pixel histograms; 2) over minimum and maximum tumor ADC; 3) on areas comparable to the highest choline (Cho)/creatine (Cr) ratio determined from chemical shift imaging (CSI); and 4) across tumor margins to measure the ADC transition coefficient (ATC).Tumor ADC was significantly different from normal brain (P \< 0.001). ADC in regions of highest Cho/Cr was greater than minimum ADC and did not correlate with the Cho/Cr ratio. ADC and ATC were not significantly different between oligodendroglial subtypes or grades. Tumors with intact 1p/19q had higher maximum (P = 0.021) and histogram ADC (P = 0.015), and greater ATC (P = 0.001) compared to those with 1p/19q loss, which may reflect differences in edema and cellularity.This preliminary study identified differences in ADC and ATC between oligodendroglial tumor genotypes that may reflect underlying biology. Confirmation in a larger series is warranted. J. Magn. Reson. Imaging 2007. {\copyright} 2007 Wiley-Liss, Inc.}, address = {Department of Neurosurgery, The Walton Centre for Neurology and Neurosurgery, Liverpool, UK; Department of Neuroradiology, The Walton Centre for Neurology and Neurosurgery, Liverpool, UK; Division of Neuroscience, University of Liverpool, Liverpool, UK; Clatterbridge Cancer Research Trust, JK Douglas Laboratories, Clatterbridge Hospital, Bebington, Wirral, UK; Leibniz-Institute for Neurobiology, Magdeburg, Germany}, author = {Jenkinson, Michael D. and Smith, Trevor S. and Brodbelt, Andrew R. and Joyce, Kathy A. and Warnke, Peter C. and Walker, Carol }, citeulike-article-id = {2066084}, doi = {http://dx.doi.org/10.1002/jmri.21062}, journal = {Journal of Magnetic Resonance Imaging}, keywords = {apparent-diffusion-coefficient, brain, cancer, dw-mri}, number = {6}, pages = {1405--1412}, posted-at = {2007-12-06 09:43:47}, priority = {5}, title = {Apparent diffusion coefficients in oligodendroglial tumors characterized by genotype}, url = {http://dx.doi.org/10.1002/jmri.21062}, volume = {26}, year = {2007} }

TY - JOUR ID - citeulike:2066084 L3 - citeulike-article-id:2066084 TI - Apparent diffusion coefficients in oligodendroglial tumors characterized by genotype JF - Journal of Magnetic Resonance Imaging VL - 26 IS - 6 SP - 1405 EP - 1412 AD - Department of Neurosurgery, The Walton Centre for Neurology and Neurosurgery, Liverpool, UK; Department of Neuroradiology, The Walton Centre for Neurology and Neurosurgery, Liverpool, UK; Division of Neuroscience, University of Liverpool, Liverpool, UK; Clatterbridge Cancer Research Trust, JK Douglas Laboratories, Clatterbridge Hospital, Bebington, Wirral, UK; Leibniz-Institute for Neurobiology, Magdeburg, Germany N2 - To investigate whether oligodendroglial tumors with or without 1p/19q loss differ in their diffusion-weighted imaging characteristics. Oligodendroglial tumors with or without 1p/19q loss differ in their therapeutic responsiveness and prognosis, and recent reports also suggest that these tumors may differ in their magnetic resonance characteristics and blood volume.Apparent diffusion coefficients (ADCs) were assessed in three grade II oligodendrogliomas, nine grade II and five grade III oligoastrocytomas with known 1p/19q status. Regions of interest (ROIs) were placed on ADC maps: 1) around tumor margins to generate pixel histograms; 2) over minimum and maximum tumor ADC; 3) on areas comparable to the highest choline (Cho)/creatine (Cr) ratio determined from chemical shift imaging (CSI); and 4) across tumor margins to measure the ADC transition coefficient (ATC).Tumor ADC was significantly different from normal brain (P < 0.001). ADC in regions of highest Cho/Cr was greater than minimum ADC and did not correlate with the Cho/Cr ratio. ADC and ATC were not significantly different between oligodendroglial subtypes or grades. Tumors with intact 1p/19q had higher maximum (P = 0.021) and histogram ADC (P = 0.015), and greater ATC (P = 0.001) compared to those with 1p/19q loss, which may reflect differences in edema and cellularity.This preliminary study identified differences in ADC and ATC between oligodendroglial tumor genotypes that may reflect underlying biology. Confirmation in a larger series is warranted. J. Magn. Reson. Imaging 2007. © 2007 Wiley-Liss, Inc. KW - apparent-diffusion-coefficient KW - brain KW - cancer KW - dw-mri AU - Jenkinson, Michael AU - Smith, Trevor AU - Brodbelt, Andrew AU - Joyce, Kathy AU - Warnke, Peter AU - Walker, Carol PY - 2007/// UR - http://dx.doi.org/10.1002/jmri.21062 ER -