Quantitative correlation between (1)H MRS and dynamic contrast-enhanced MRI of human breast cancer. Export

@article{citeulike:3916819, abstract = {Proton magnetic resonance spectroscopy ((1)H MRS) and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) provide functional information, including vascular volume, vascular permeability and choline (Cho) metabolism. In this study, we applied these two imaging modalities to quantitatively characterize 36 malignant breast lesions in 32 patients and analyzed the correlation between them. Cho concentration was quantified by single-voxel (1)H MRS using water as an internal reference. The measured Cho levels ranged from 0.32 to 10.47 mmol/kg, consistent with previously reported values. In 25 mass-type lesions, the Cho concentration was significantly correlated with tumor size (r=.69, P<.0002). In addition, the Cho level was found to be significantly higher in lesions presenting as mass-type lesions compared to non-mass-type diffuse enhancements (P=.035). The enhancement kinetics from tissues covered within each MRS voxel were measured and analyzed with a two-compartmental model to obtain pharmacokinetic parameters K(trans) and k(ep). A significant correlation was found between the Cho level and the pharmacokinetic parameter k(ep) (r=.62, P<.0001), indicating that tissues with a high Cho level have higher wash-out rates in DCE MRI. The results suggest a correlation between Cho metabolism and angiogenesis activity, which might be explained by the association of Cho with cell replication and angiogenesis required to support tumor growth.}, author = {Baek, H. M. and Yu, H. J. and Chen, J. H. and Nalcioglu, O. and Su, M. Y.}, citeulike-article-id = {3916819}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.mri.2007.10.002}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18060716}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18060716}, doi = {10.1016/j.mri.2007.10.002}, issn = {0730-725X}, journal = {Magnetic resonance imaging}, keywords = {breast, cancer, choline, dce-mri, mri, spectroscopy}, month = {May}, number = {4}, pages = {523--531}, posted-at = {2009-01-20 21:23:14}, priority = {5}, title = {Quantitative correlation between (1)H MRS and dynamic contrast-enhanced MRI of human breast cancer.}, url = {http://dx.doi.org/10.1016/j.mri.2007.10.002}, volume = {26}, year = {2008} }

TY - JOUR ID - citeulike:3916819 L3 - citeulike-article-id:3916819 N2 - Proton magnetic resonance spectroscopy ((1)H MRS) and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) provide functional information, including vascular volume, vascular permeability and choline (Cho) metabolism. In this study, we applied these two imaging modalities to quantitatively characterize 36 malignant breast lesions in 32 patients and analyzed the correlation between them. Cho concentration was quantified by single-voxel (1)H MRS using water as an internal reference. The measured Cho levels ranged from 0.32 to 10.47 mmol/kg, consistent with previously reported values. In 25 mass-type lesions, the Cho concentration was significantly correlated with tumor size (r=.69, P<.0002). In addition, the Cho level was found to be significantly higher in lesions presenting as mass-type lesions compared to non-mass-type diffuse enhancements (P=.035). The enhancement kinetics from tissues covered within each MRS voxel were measured and analyzed with a two-compartmental model to obtain pharmacokinetic parameters K(trans) and k(ep). A significant correlation was found between the Cho level and the pharmacokinetic parameter k(ep) (r=.62, P<.0001), indicating that tissues with a high Cho level have higher wash-out rates in DCE MRI. The results suggest a correlation between Cho metabolism and angiogenesis activity, which might be explained by the association of Cho with cell replication and angiogenesis required to support tumor growth. IS - 4 JF - Magnetic resonance imaging SN - 0730-725X EP - 531 TI - Quantitative correlation between (1)H MRS and dynamic contrast-enhanced MRI of human breast cancer. VL - 26 SP - 523 KW - breast KW - cancer KW - choline KW - dce-mri KW - mri KW - spectroscopy AU - Baek, HM AU - Yu, HJ AU - Chen, JH AU - Nalcioglu, O AU - Su, MY PY - 2008/05// UR - http://dx.doi.org/10.1016/j.mri.2007.10.002 ER -