Diffusion-Weighted Magnetic Resonance Imaging for Predicting and Detecting Early Response to Chemoradiation Therapy of Squamous Cell Carcinomas of the Head and Neck Export

@article{citeulike:4292612, abstract = {Purpose: The aim of this study was to investigate the utility of apparent diffusion coefficient (ADC) for prediction and early detection of treatment response in head and neck squamous cell carcinomas (HNSCC). Experimental Design: Diffusion-weighted magnetic resonance imaging studies were performed on 40 patients with newly diagnosed HNSCC before, during, and after the end of chemoradiation therapy. Analysis was done on data from 33 patients after exclusion of 7 patients that had incomplete data. Results: Pretreatment ADC value of complete responders (1.04 {+/-} 0.19 x 10-3 mm2/s) was significantly lower (P < 0.05) than that from partial responders (1.35 {+/-} 0.30 x 10-3 mm2/s). A significant increase in ADC was observed in complete responders within 1 week of treatment (P < 0.01), which remained high until the end of the treatment. The complete responders also showed significantly higher increase in ADC than the partial responders by the first week of chemoradiation (P < 0.01). When pretreatment ADC value was used for predicting treatment response, the area under the receiver operating characteristic curve was 0.80 with a sensitivity of 65\% and a specificity of 86\%. However, change in ADC within the first week of chemoradiation therapy resulted in an area under the receiver operating characteristic curve of 0.88 with 86\% sensitivity and 83\% specificity for prediction of treatment response. Conclusions: These results suggest that ADC can be used as a marker for prediction and early detection of response to concurrent chemoradiation therapy in HNSCC. 10.1158/1078-0432.CCR-08-1287}, author = {Kim, Sungheon and Loevner, Laurie and Quon, Harry and Sherman, Eric and Weinstein, Gregory and Kilger, Alex and Poptani, Harish}, citeulike-article-id = {4292612}, citeulike-linkout-0 = {http://dx.doi.org/10.1158/1078-0432.CCR-08-1287}, citeulike-linkout-1 = {http://clincancerres.aacrjournals.org/cgi/content/abstract/15/3/986}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19188170}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19188170}, day = {1}, doi = {10.1158/1078-0432.CCR-08-1287}, journal = {Clin Cancer Res}, keywords = {adc, biomarker, cancer, chemotherapy, dw-mri, human, predictive}, month = {February}, number = {3}, pages = {986--994}, posted-at = {2009-04-08 21:59:44}, priority = {4}, title = {Diffusion-Weighted Magnetic Resonance Imaging for Predicting and Detecting Early Response to Chemoradiation Therapy of Squamous Cell Carcinomas of the Head and Neck}, url = {http://dx.doi.org/10.1158/1078-0432.CCR-08-1287}, volume = {15}, year = {2009} }

TY - JOUR ID - citeulike:4292612 L3 - citeulike-article-id:4292612 N2 - Purpose: The aim of this study was to investigate the utility of apparent diffusion coefficient (ADC) for prediction and early detection of treatment response in head and neck squamous cell carcinomas (HNSCC). Experimental Design: Diffusion-weighted magnetic resonance imaging studies were performed on 40 patients with newly diagnosed HNSCC before, during, and after the end of chemoradiation therapy. Analysis was done on data from 33 patients after exclusion of 7 patients that had incomplete data. Results: Pretreatment ADC value of complete responders (1.04 {+/-} 0.19 x 10-3 mm2/s) was significantly lower (P < 0.05) than that from partial responders (1.35 {+/-} 0.30 x 10-3 mm2/s). A significant increase in ADC was observed in complete responders within 1 week of treatment (P < 0.01), which remained high until the end of the treatment. The complete responders also showed significantly higher increase in ADC than the partial responders by the first week of chemoradiation (P < 0.01). When pretreatment ADC value was used for predicting treatment response, the area under the receiver operating characteristic curve was 0.80 with a sensitivity of 65% and a specificity of 86%. However, change in ADC within the first week of chemoradiation therapy resulted in an area under the receiver operating characteristic curve of 0.88 with 86% sensitivity and 83% specificity for prediction of treatment response. Conclusions: These results suggest that ADC can be used as a marker for prediction and early detection of response to concurrent chemoradiation therapy in HNSCC. 10.1158/1078-0432.CCR-08-1287 IS - 3 JF - Clin Cancer Res EP - 994 TI - Diffusion-Weighted Magnetic Resonance Imaging for Predicting and Detecting Early Response to Chemoradiation Therapy of Squamous Cell Carcinomas of the Head and Neck VL - 15 SP - 986 KW - adc KW - biomarker KW - cancer KW - chemotherapy KW - dw-mri KW - human KW - predictive AU - Kim, Sungheon AU - Loevner, Laurie AU - Quon, Harry AU - Sherman, Eric AU - Weinstein, Gregory AU - Kilger, Alex AU - Poptani, Harish PY - 2009/02/01/ UR - http://dx.doi.org/10.1158/1078-0432.CCR-08-1287 ER -