A method for interleaved acquisition of a vascular input function for dynamic contrast-enhanced MRI in experimental rat tumours Export

@article{citeulike:711429, abstract = {Dynamic contrast-enhanced MRI is widely used for the evaluation of the response of experimental rodent tumours to antitumour therapy, particularly for the newly developing antiangiogenic and antivascular agents. However, standard models require a time-course for the plasma concentration of contrast agent (usually referred to as the arterial input function) to calculate the transfer constant Ktrans from the dynamic time-course data. Ideally, the plasma concentration time-course should be measured during each experiment to obtain the most accurate measure of Ktrans. This is technically difficult in rodents, so assumed values are generally used. A method is presented here using interleaved acquisitions from a tail coil to obtain the plasma concentration simultaneously with DCE-MRI data obtained from a solenoid coil around the tumour. The SNR of the resulting vascular input function data is high compared with methods using a volume coil to acquire plasma concentrations from the aorta and vena cava. Copyright {\copyright} 2004 John Wiley \& Sons, Ltd.}, address = {Cancer Research UK Biomedical MR Research Group, Department of Basic Medical Sciences, St George's Hospital Medical School, Cranmer Terrace, Tooting, London SW17 0RE, UK}, author = {Mcintyre, Dominick J. O. and Ludwig, Christian and Pasan, Amit and Griffiths, John R.}, citeulike-article-id = {711429}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/nbm.868}, citeulike-linkout-1 = {http://www3.interscience.wiley.com/cgi-bin/abstract/108561591/ABSTRACT}, doi = {10.1002/nbm.868}, journal = {NMR in Biomedicine}, keywords = {dce-mri, mri, perfusion}, number = {3}, pages = {132--143}, posted-at = {2006-06-26 16:00:34}, priority = {2}, title = {A method for interleaved acquisition of a vascular input function for dynamic contrast-enhanced MRI in experimental rat tumours}, url = {http://dx.doi.org/10.1002/nbm.868}, volume = {17}, year = {2004} }

TY - JOUR ID - citeulike:711429 L3 - citeulike-article-id:711429 N2 - Dynamic contrast-enhanced MRI is widely used for the evaluation of the response of experimental rodent tumours to antitumour therapy, particularly for the newly developing antiangiogenic and antivascular agents. However, standard models require a time-course for the plasma concentration of contrast agent (usually referred to as the arterial input function) to calculate the transfer constant Ktrans from the dynamic time-course data. Ideally, the plasma concentration time-course should be measured during each experiment to obtain the most accurate measure of Ktrans. This is technically difficult in rodents, so assumed values are generally used. A method is presented here using interleaved acquisitions from a tail coil to obtain the plasma concentration simultaneously with DCE-MRI data obtained from a solenoid coil around the tumour. The SNR of the resulting vascular input function data is high compared with methods using a volume coil to acquire plasma concentrations from the aorta and vena cava. Copyright © 2004 John Wiley & Sons, Ltd. IS - 3 JF - NMR in Biomedicine AD - Cancer Research UK Biomedical MR Research Group, Department of Basic Medical Sciences, St George's Hospital Medical School, Cranmer Terrace, Tooting, London SW17 0RE, UK EP - 143 TI - A method for interleaved acquisition of a vascular input function for dynamic contrast-enhanced MRI in experimental rat tumours VL - 17 SP - 132 KW - dce-mri KW - mri KW - perfusion AU - Mcintyre, Dominick AU - Ludwig, Christian AU - Pasan, Amit AU - Griffiths, John PY - 2004/// UR - http://dx.doi.org/10.1002/nbm.868 ER -