The extent of linkage disequilibrium in Arabidopsis thaliana. Export

@article{citeulike:420743, abstract = {Linkage disequilibrium (LD), the nonrandom occurrence of alleles in haplotypes, has long been of interest to population geneticists. Recently, the rapidly increasing availability of genomic polymorphism data has fueled interest in LD as a tool for fine-scale mapping, in particular for human disease loci. The chromosomal extent of LD is crucial in this context, because it determines how dense a map must be for associations to be detected and, conversely, limits how finely loci may be mapped. Arabidopsis thaliana is expected to harbor unusually extensive LD because of its high degree of selfing. Several polymorphism studies have found very strong LD within individual loci, but also evidence of some recombination. Here we investigate the pattern of LD on a genomic scale and show that in global samples, LD decays within approximately 1 cM, or 250 kb. We also show that LD in local populations may be much stronger than that of global populations, presumably as a result of founder events. The combination of a relatively high level of polymorphism and extensive haplotype structure bodes well for developing a genome-wide LD map in A. thaliana.}, address = {Department of Biological Sciences, University of Southern California, Los Angeles, California 90089, USA.}, author = {Nordborg, M. and Borevitz, J. O. and Bergelson, J. and Berry, C. C. and Chory, J. and Hagenblad, J. and Kreitman, M. and Maloof, J. N. and Noyes, T. and Oefner, P. J. and Stahl, E. A. and Weigel, D.}, citeulike-article-id = {420743}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/ng813}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/11780140}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=11780140}, doi = {10.1038/ng813}, issn = {1061-4036}, journal = {Nat Genet}, month = {February}, number = {2}, pages = {190--193}, posted-at = {2005-12-03 09:00:33}, priority = {3}, title = {The extent of linkage disequilibrium in Arabidopsis thaliana.}, url = {http://dx.doi.org/10.1038/ng813}, volume = {30}, year = {2002} }

TY - JOUR ID - citeulike:420743 L3 - citeulike-article-id:420743 N2 - Linkage disequilibrium (LD), the nonrandom occurrence of alleles in haplotypes, has long been of interest to population geneticists. Recently, the rapidly increasing availability of genomic polymorphism data has fueled interest in LD as a tool for fine-scale mapping, in particular for human disease loci. The chromosomal extent of LD is crucial in this context, because it determines how dense a map must be for associations to be detected and, conversely, limits how finely loci may be mapped. Arabidopsis thaliana is expected to harbor unusually extensive LD because of its high degree of selfing. Several polymorphism studies have found very strong LD within individual loci, but also evidence of some recombination. Here we investigate the pattern of LD on a genomic scale and show that in global samples, LD decays within approximately 1 cM, or 250 kb. We also show that LD in local populations may be much stronger than that of global populations, presumably as a result of founder events. The combination of a relatively high level of polymorphism and extensive haplotype structure bodes well for developing a genome-wide LD map in A. thaliana. IS - 2 JF - Nat Genet SN - 1061-4036 AD - Department of Biological Sciences, University of Southern California, Los Angeles, California 90089, USA. EP - 193 TI - The extent of linkage disequilibrium in Arabidopsis thaliana. VL - 30 SP - 190 AU - Nordborg, M AU - Borevitz, JO AU - Bergelson, J AU - Berry, CC AU - Chory, J AU - Hagenblad, J AU - Kreitman, M AU - Maloof, JN AU - Noyes, T AU - Oefner, PJ AU - Stahl, EA AU - Weigel, D PY - 2002/02// UR - http://dx.doi.org/10.1038/ng813 ER -