Genome-Wide Prediction of C. elegans Genetic Interactions Export

@article{citeulike:543344, abstract = {To obtain a global view of functional interactions among genes in a metazoan genome, we computationally integrated interactome data, gene expression data, phenotype data, and functional annotation data from three model organisms--Saccharomyces cerevisiae, Caenorhabditis elegans, and Drosophila melanogaster--and predicted genome-wide genetic interactions in C. elegans. The resulting genetic interaction network (consisting of 18,183 interactions) provides a framework for system-level understanding of gene functions. We experimentally tested the predicted interactions for two human disease-related genes and identified 14 new modifiers.}, author = {Zhong, Weiwei and Sternberg, Paul W.}, citeulike-article-id = {543344}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1123287}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/311/5766/1481}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/16527984}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=16527984}, citeulike-linkout-4 = {http://www.wormbase.org/db/misc/paper?name=WBPaper00027155}, day = {10}, doi = {10.1126/science.1123287}, journal = {Science}, keywords = {c, elegans, genome, genome\_alignment, human\_genome, interactions}, month = {March}, number = {5766}, pages = {1481--1484}, posted-at = {2006-03-11 04:12:04}, priority = {3}, title = {Genome-Wide Prediction of C. elegans Genetic Interactions}, url = {http://dx.doi.org/10.1126/science.1123287}, volume = {311}, year = {2006} }

TY - JOUR ID - citeulike:543344 L3 - citeulike-article-id:543344 N2 - To obtain a global view of functional interactions among genes in a metazoan genome, we computationally integrated interactome data, gene expression data, phenotype data, and functional annotation data from three model organisms--Saccharomyces cerevisiae, Caenorhabditis elegans, and Drosophila melanogaster--and predicted genome-wide genetic interactions in C. elegans. The resulting genetic interaction network (consisting of 18,183 interactions) provides a framework for system-level understanding of gene functions. We experimentally tested the predicted interactions for two human disease-related genes and identified 14 new modifiers. IS - 5766 JF - Science EP - 1484 TI - Genome-Wide Prediction of C. elegans Genetic Interactions VL - 311 SP - 1481 KW - c KW - elegans KW - genome KW - genome_alignment KW - human_genome KW - interactions AU - Zhong, Weiwei AU - Sternberg, Paul PY - 2006/03/10/ UR - http://dx.doi.org/10.1126/science.1123287 ER -