Antisense transcription in the mammalian transcriptome. Export

@article{citeulike:697743, abstract = {Antisense transcription (transcription from the opposite strand to a protein-coding or sense strand) has been ascribed roles in gene regulation involving degradation of the corresponding sense transcripts (RNA interference), as well as gene silencing at the chromatin level. Global transcriptome analysis provides evidence that a large proportion of the genome can produce transcripts from both strands, and that antisense transcripts commonly link neighboring "genes" in complex loci into chains of linked transcriptional units. Expression profiling reveals frequent concordant regulation of sense/antisense pairs. We present experimental evidence that perturbation of an antisense RNA can alter the expression of sense messenger RNAs, suggesting that antisense transcription contributes to control of transcriptional outputs in mammals.}, address = {Laboratory for Genome Exploration Research Group, RIKEN Genomic Sciences Centre (GSC), RIKEN Yokohama Institute, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, 230-0045, Japan.}, author = {Katayama, S. and Tomaru, Y. and Kasukawa, T. and Waki, K. and Nakanishi, M. and Nakamura, M. and Nishida, H. and Yap, C. C. and Suzuki, M. and Kawai, J. and Suzuki, H. and Carninci, P. and Hayashizaki, Y. and Wells, C. and Frith, M. and Ravasi, T. and Pang, K. C. and Hallinan, J. and Mattick, J. and Hume, D. A. and Lipovich, L. and Batalov, S. and Engstr\"{o}m, P. G. and Mizuno, Y. and Faghihi, M. A. and Sandelin, A. and Chalk, A. M. and Mottagui-Tabar, S. and Liang, Z. and Lenhard, B. and Wahlestedt, C. and {RIKEN Genome Exploration Research Group} and {Genome Science Group (Genome Network Project Core Group)} and {FANTOM Consortium}}, citeulike-article-id = {697743}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1112009}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/309/5740/1564}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/16141073}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=16141073}, day = {2}, doi = {10.1126/science.1112009}, issn = {1095-9203}, journal = {Science (New York, N.Y.)}, keywords = {antisense, human\_genome, mammal, sense}, month = {September}, number = {5740}, pages = {1564--1566}, posted-at = {2006-06-16 03:10:37}, priority = {3}, title = {Antisense transcription in the mammalian transcriptome.}, url = {http://dx.doi.org/10.1126/science.1112009}, volume = {309}, year = {2005} }

TY - JOUR ID - citeulike:697743 L3 - citeulike-article-id:697743 N2 - Antisense transcription (transcription from the opposite strand to a protein-coding or sense strand) has been ascribed roles in gene regulation involving degradation of the corresponding sense transcripts (RNA interference), as well as gene silencing at the chromatin level. Global transcriptome analysis provides evidence that a large proportion of the genome can produce transcripts from both strands, and that antisense transcripts commonly link neighboring "genes" in complex loci into chains of linked transcriptional units. Expression profiling reveals frequent concordant regulation of sense/antisense pairs. We present experimental evidence that perturbation of an antisense RNA can alter the expression of sense messenger RNAs, suggesting that antisense transcription contributes to control of transcriptional outputs in mammals. IS - 5740 JF - Science (New York, N.Y.) SN - 1095-9203 AD - Laboratory for Genome Exploration Research Group, RIKEN Genomic Sciences Centre (GSC), RIKEN Yokohama Institute, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, 230-0045, Japan. EP - 1566 TI - Antisense transcription in the mammalian transcriptome. VL - 309 SP - 1564 KW - antisense KW - human_genome KW - mammal KW - sense AU - Katayama, S AU - Tomaru, Y AU - Kasukawa, T AU - Waki, K AU - Nakanishi, M AU - Nakamura, M AU - Nishida, H AU - Yap, CC AU - Suzuki, M AU - Kawai, J AU - Suzuki, H AU - Carninci, P AU - Hayashizaki, Y AU - Wells, C AU - Frith, M AU - Ravasi, T AU - Pang, KC AU - Hallinan, J AU - Mattick, J AU - Hume, DA AU - Lipovich, L AU - Batalov, S AU - Engström, PG AU - Mizuno, Y AU - Faghihi, MA AU - Sandelin, A AU - Chalk, AM AU - Mottagui-Tabar, S AU - Liang, Z AU - Lenhard, B AU - Wahlestedt, C PY - 2005/09/02/ UR - http://dx.doi.org/10.1126/science.1112009 ER -