Parallel patterns of evolution in the genomes and transcriptomes of humans and chimpanzees. Export

@article{citeulike:771646, abstract = {The determination of the chimpanzee genome sequence provides a means to study both structural and functional aspects of the evolution of the human genome. Here we compare humans and chimpanzees with respect to differences in expression levels and protein-coding sequences for genes active in brain, heart, liver, kidney, and testis. We find that the patterns of differences in gene expression and gene sequences are markedly similar. In particular, there is a gradation of selective constraints among the tissues so that the brain shows the least differences between the species whereas liver shows the most. Furthermore, expression levels as well as amino acid sequences of genes active in more tissues have diverged less between the species than have genes active in fewer tissues. In general, these patterns are consistent with a model of neutral evolution with negative selection. However, for X-chromosomal genes expressed in testis, patterns suggestive of positive selection on sequence changes as well as expression changes are seen. Furthermore, although genes expressed in the brain have changed less than have genes expressed in other tissues, in agreement with previous work we find that genes active in brain have accumulated more changes on the human than on the chimpanzee lineage.}, address = {Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103 Leipzig, Germany.}, author = {Khaitovich, Philipp and Hellmann, Ines and Enard, Wolfgang and Nowick, Katja and Leinweber, Marcus and Franz, Henriette and Weiss, Gunter and Lachmann, Michael and P\"{a}\"{a}bo, Svante}, citeulike-article-id = {771646}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1108296}, citeulike-linkout-1 = {http://www.sciencemag.org/content/309/5742/1850.abstract}, citeulike-linkout-2 = {http://www.sciencemag.org/content/309/5742/1850.full.pdf}, citeulike-linkout-3 = {http://www.sciencemag.org/cgi/content/abstract/309/5742/1850}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/16141373}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=16141373}, day = {16}, doi = {10.1126/science.1108296}, issn = {1095-9203}, journal = {Science (New York, N.Y.)}, keywords = {co-expression, comparative\_study, human, mammal, transcriptome}, month = {September}, number = {5742}, pages = {1850--1854}, posted-at = {2008-09-22 02:29:15}, priority = {2}, title = {Parallel patterns of evolution in the genomes and transcriptomes of humans and chimpanzees.}, url = {http://dx.doi.org/10.1126/science.1108296}, volume = {309}, year = {2005} }

TY - JOUR ID - citeulike:771646 L3 - citeulike-article-id:771646 N2 - The determination of the chimpanzee genome sequence provides a means to study both structural and functional aspects of the evolution of the human genome. Here we compare humans and chimpanzees with respect to differences in expression levels and protein-coding sequences for genes active in brain, heart, liver, kidney, and testis. We find that the patterns of differences in gene expression and gene sequences are markedly similar. In particular, there is a gradation of selective constraints among the tissues so that the brain shows the least differences between the species whereas liver shows the most. Furthermore, expression levels as well as amino acid sequences of genes active in more tissues have diverged less between the species than have genes active in fewer tissues. In general, these patterns are consistent with a model of neutral evolution with negative selection. However, for X-chromosomal genes expressed in testis, patterns suggestive of positive selection on sequence changes as well as expression changes are seen. Furthermore, although genes expressed in the brain have changed less than have genes expressed in other tissues, in agreement with previous work we find that genes active in brain have accumulated more changes on the human than on the chimpanzee lineage. IS - 5742 JF - Science (New York, N.Y.) SN - 1095-9203 AD - Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103 Leipzig, Germany. EP - 1854 TI - Parallel patterns of evolution in the genomes and transcriptomes of humans and chimpanzees. VL - 309 SP - 1850 KW - co-expression KW - comparative_study KW - human KW - mammal KW - transcriptome AU - Khaitovich, Philipp AU - Hellmann, Ines AU - Enard, Wolfgang AU - Nowick, Katja AU - Leinweber, Marcus AU - Franz, Henriette AU - Weiss, Gunter AU - Lachmann, Michael AU - Pääbo, Svante PY - 2005/09/16/ UR - http://dx.doi.org/10.1126/science.1108296 ER -