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Gene Expression Profiling after Radiation-Induced DNA Damage Is Strongly Predictive of BRCA1 Mutation Carrier Status

by: Zsofia Kote-Jarai, Richard D. Williams, Nicola Cattini, Maria Copeland, Ian Giddings, Richard Wooster, Robert H. tePoele, Paul Workman, Barry Gusterson, John Peacock, Gerald Gui, Colin Campbell, Ros Eeles
Clinical Cancer Research, Vol. 10, No. 3. (01 February 2004), pp. 958-963, doi:10.1158/1078-0432.ccr-1067-3  Key: citeulike:11265648

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Abstract

Purpose: The impact of the presence of a germ-line BRCA1 mutation on gene expression in normal breast fibroblasts after radiation-induced DNA damage has been investigated.


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