AMP-activated protein kinase: the energy charge hypothesis revisited. Export

@article{citeulike:2728279, abstract = {The AMP-activated protein kinase cascade is a sensor of cellular energy charge, and its existence provides strong support for the energy charge hypothesis first proposed by Daniel Atkinson in the 1960s. The system is activated in an ultrasensitive manner by cellular stresses that deplete ATP (and consequently elevate AMP), either by inhibiting ATP production (e.g., hypoxia), or by accelerating ATP consumption (e.g., exercise in muscle). Once activated, it switches on catabolic pathways, both acutely by phosphorylation of metabolic enzymes and chronically by effects on gene expression, and switches off many ATP-consuming processes. Recent work suggests that activation of AMPK is responsible for many of the effects of physical exercise, both the rapid metabolic effects and the adaptations that occur during training. Dominant mutations in regulatory subunit isoforms (gamma2 and gamma3) of AMPK, which appear to increase the basal activity in the absence of AMP, lead to hypertrophy of cardiac and skeletal muscle respectively.}, address = {Wellcome Trust Biocentre, Division of Molecular Physiology, Dundee University, Dundee, Scotland, UK. d.g.hardie@dundee.ac.uk}, author = {Hardie, D. G. and Hawley, S. A.}, citeulike-article-id = {2728279}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/bies.10009}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/11746230}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=11746230}, comment = {AMPKは細胞内のエネルギー状態，酸素状態，ストレス状態を反映すると考えられるAMP/ATP比を鋭敏に感知して活性化する． 細胞内の代謝センサー・燃料ゲージとよばれ細胞での糖脂質代謝の方向を調節する．}, doi = {10.1002/bies.10009}, issn = {0265-9247}, journal = {BioEssays : news and reviews in molecular, cellular and developmental biology}, keywords = {ampk, annual2004, metabolism}, month = {December}, number = {12}, pages = {1112--1119}, posted-at = {2008-04-28 08:24:08}, priority = {2}, title = {AMP-activated protein kinase: the energy charge hypothesis revisited.}, url = {http://dx.doi.org/10.1002/bies.10009}, volume = {23}, year = {2001} }

TY - JOUR ID - citeulike:2728279 L3 - citeulike-article-id:2728279 N2 - The AMP-activated protein kinase cascade is a sensor of cellular energy charge, and its existence provides strong support for the energy charge hypothesis first proposed by Daniel Atkinson in the 1960s. The system is activated in an ultrasensitive manner by cellular stresses that deplete ATP (and consequently elevate AMP), either by inhibiting ATP production (e.g., hypoxia), or by accelerating ATP consumption (e.g., exercise in muscle). Once activated, it switches on catabolic pathways, both acutely by phosphorylation of metabolic enzymes and chronically by effects on gene expression, and switches off many ATP-consuming processes. Recent work suggests that activation of AMPK is responsible for many of the effects of physical exercise, both the rapid metabolic effects and the adaptations that occur during training. Dominant mutations in regulatory subunit isoforms (gamma2 and gamma3) of AMPK, which appear to increase the basal activity in the absence of AMP, lead to hypertrophy of cardiac and skeletal muscle respectively. IS - 12 JF - BioEssays : news and reviews in molecular, cellular and developmental biology SN - 0265-9247 AD - Wellcome Trust Biocentre, Division of Molecular Physiology, Dundee University, Dundee, Scotland, UK. d.g.hardie@dundee.ac.uk EP - 1119 TI - AMP-activated protein kinase: the energy charge hypothesis revisited. VL - 23 SP - 1112 KW - ampk KW - annual2004 KW - metabolism N1 - AMPKは細胞内のエネルギー状態，酸素状態，ストレス状態を反映すると考えられるAMP/ATP比を鋭敏に感知して活性化する． 細胞内の代謝センサー・燃料ゲージとよばれ細胞での糖脂質代謝の方向を調節する． AU - Hardie, DG AU - Hawley, SA PY - 2001/12// UR - http://dx.doi.org/10.1002/bies.10009 ER -