Increased adiponectin secretion by highly purified eicosapentaenoic acid in rodent models of obesity and human obese subjects Export

@article{Itoh:2007p69, abstract = {OBJECTIVES: Fish oil rich in n-3 polyunsaturated fatty acids (PUFAs) or n-3 PUFAs have been shown to reduce the incidence of coronary heart disease. Here we investigated the effect of highly purified eicosapentaenoic acid (EPA) on production of adiponectin, the only established antiatherogenic and antiinflammatory adipocytokine, in rodent models of obesity and human obese subjects. METHODS AND RESULTS: We demonstrated that EPA increases adiponectin secretion in genetically obese ob/ob mice and high-fat diet-induced obese mice. In the in vitro coculture of adipocytes and macrophages, EPA reversed the coculture-induced decrease in adiponectin secretion at least in part through downregulation of tumor necrosis factor-alpha in macrophages. We also showed significant increase in plasma adiponectin concentrations in human obese subjects after a 3-month treatment with EPA (1.8 g daily). Multivariate regression analysis revealed that EPA treatment is the only independent determinant of plasma adiponectin concentrations. CONCLUSION: This study demonstrates that EPA increases adiponectin secretion in rodent models of obesity and human obese subjects, possibly through the improvement of the inflammatory changes in obese adipose tissue. Because EPA has reduced the risk of major coronary events in a large-scale, prospective, randomized clinical trial, this study provides important insight into its therapeutic implication in obesity-related metabolic sequelae.}, author = {Itoh, Michiko and Suganami, Takayoshi and Satoh, Noriko and Koyama, Kanami T. and Yuan, Xunmei and Tanaka, Miyako and Kawano, Hiroyuki and Yano, Takashi and Aoe, Seiichiro and Takeya, Motohiro and Shimatsu, Akira and Kuzuya, Hideshi and Kamei, Yasutomi and Ogawa, Yoshihiro}, citeulike-article-id = {3046180}, citeulike-linkout-0 = {http://atvb.ahajournals.org/cgi/content/full/27/9/1918}, citeulike-linkout-1 = {http://dx.doi.org/10.1161/ATVBAHA.106.136853}, doi = {10.1161/ATVBAHA.106.136853}, journal = {Arterioscler Thromb Vasc Biol}, keywords = {acid, adipocytes, adiponectin, adipose, aged, agents, animals, anti-obesity, coculture, eicosapentaenoic, fatty, female, file-import-08-07-27, humans, hyperlipidemias, inflammation, liver, macrophages, male, mice, middle, obese, obesity, techniques, tissue, triglycerides, white}, local-url = {file://localhost/Users/ken/Documents/Papers/2007/Itoh/Arterioscler\%20Thromb\%20Vasc\%20Biol\%202007\%20Itoh.pdf}, month = {Sep}, number = {9}, pages = {1918--25}, posted-at = {2008-07-27 14:45:59}, priority = {2}, title = {Increased adiponectin secretion by highly purified eicosapentaenoic acid in rodent models of obesity and human obese subjects}, url = {http://dx.doi.org/10.1161/ATVBAHA.106.136853}, volume = {27}, year = {2007} }

TY - JOUR ID - Itoh:2007p69 L3 - citeulike-article-id:3046180 N2 - OBJECTIVES: Fish oil rich in n-3 polyunsaturated fatty acids (PUFAs) or n-3 PUFAs have been shown to reduce the incidence of coronary heart disease. Here we investigated the effect of highly purified eicosapentaenoic acid (EPA) on production of adiponectin, the only established antiatherogenic and antiinflammatory adipocytokine, in rodent models of obesity and human obese subjects. METHODS AND RESULTS: We demonstrated that EPA increases adiponectin secretion in genetically obese ob/ob mice and high-fat diet-induced obese mice. In the in vitro coculture of adipocytes and macrophages, EPA reversed the coculture-induced decrease in adiponectin secretion at least in part through downregulation of tumor necrosis factor-alpha in macrophages. We also showed significant increase in plasma adiponectin concentrations in human obese subjects after a 3-month treatment with EPA (1.8 g daily). Multivariate regression analysis revealed that EPA treatment is the only independent determinant of plasma adiponectin concentrations. CONCLUSION: This study demonstrates that EPA increases adiponectin secretion in rodent models of obesity and human obese subjects, possibly through the improvement of the inflammatory changes in obese adipose tissue. Because EPA has reduced the risk of major coronary events in a large-scale, prospective, randomized clinical trial, this study provides important insight into its therapeutic implication in obesity-related metabolic sequelae. IS - 9 JF - Arterioscler Thromb Vasc Biol EP - 25 TI - Increased adiponectin secretion by highly purified eicosapentaenoic acid in rodent models of obesity and human obese subjects VL - 27 SP - 1918 KW - acid KW - adipocytes KW - adiponectin KW - adipose KW - aged KW - agents KW - animals KW - anti-obesity KW - coculture KW - eicosapentaenoic KW - fatty KW - female KW - file-import-08-07-27 KW - humans KW - hyperlipidemias KW - inflammation KW - liver KW - macrophages KW - male KW - mice KW - middle KW - obese KW - obesity KW - techniques KW - tissue KW - triglycerides KW - white AU - Itoh, Michiko AU - Suganami, Takayoshi AU - Satoh, Noriko AU - Koyama, Kanami AU - Yuan, Xunmei AU - Tanaka, Miyako AU - Kawano, Hiroyuki AU - Yano, Takashi AU - Aoe, Seiichiro AU - Takeya, Motohiro AU - Shimatsu, Akira AU - Kuzuya, Hideshi AU - Kamei, Yasutomi AU - Ogawa, Yoshihiro PY - 2007/Sep// UR - http://dx.doi.org/10.1161/ATVBAHA.106.136853 ER -