PPARgamma activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties Export

@article{Bouhlel:2007p1194, abstract = {Th1 cytokines promote monocyte differentiation into proatherogenic M1 macrophages, while Th2 cytokines lead to an "alternative" anti-inflammatory M2 macrophage phenotype. Here we show that in human atherosclerotic lesions, the expression of M2 markers and PPARgamma, a nuclear receptor controlling macrophage inflammation, correlate positively. Moreover, PPARgamma activation primes primary human monocytes into M2 differentiation, resulting in a more pronounced anti-inflammatory activity in M1 macrophages. However, PPARgamma activation does not influence M2 marker expression in resting or M1 macrophages, nor does PPARgamma agonist treatment influence the expression of M2 markers in atherosclerotic lesions, indicating that only native monocytes can be primed by PPARgamma activation to an enhanced M2 phenotype. Furthermore, PPARgamma activation significantly increases expression of the M2 marker MR in circulating peripheral blood mononuclear cells. These data demonstrate that PPARgamma activation skews human monocytes toward an anti-inflammatory M2 phenotype.}, author = {Bouhlel, Amine M. and Derudas, Bruno and Rigamonti, Elena and Di{\`{e}}vart, R{\'{e}}becca and Brozek, John and Haulon, St{\'{e}}phan and Zawadzki, Christophe and Jude, Brigitte and Torpier, G{\'{e}}rard and Marx, Nikolaus and Staels, Bart and Gbaguidi, Giulia C.}, citeulike-article-id = {3046188}, citeulike-linkout-0 = {http://linkinghub.elsevier.com/retrieve/pii/S1550-4131(07)00166-0}, citeulike-linkout-1 = {http://dx.doi.org/10.1016/j.cmet.2007.06.010}, doi = {10.1016/j.cmet.2007.06.010}, journal = {Cell Metab}, keywords = {artery, benzophenones, biological, blood, carotid, cell, cells, communication, cultured, differentiation, diseases, file-import-08-07-27, foam, gamma, humans, inflammation, macrophages, markers, monocytes, paracrine, phenotype, ppar, stem, tyrosine}, local-url = {file://localhost/Users/ken/Documents/Papers/2007/Bouhlel/Cell\%20Metab\%202007\%20Bouhlel.pdf}, month = {Aug}, number = {2}, pages = {137--43}, posted-at = {2008-07-27 14:46:02}, priority = {2}, title = {PPARgamma activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties}, url = {http://dx.doi.org/10.1016/j.cmet.2007.06.010}, volume = {6}, year = {2007} }

TY - JOUR ID - Bouhlel:2007p1194 L3 - citeulike-article-id:3046188 N2 - Th1 cytokines promote monocyte differentiation into proatherogenic M1 macrophages, while Th2 cytokines lead to an "alternative" anti-inflammatory M2 macrophage phenotype. Here we show that in human atherosclerotic lesions, the expression of M2 markers and PPARgamma, a nuclear receptor controlling macrophage inflammation, correlate positively. Moreover, PPARgamma activation primes primary human monocytes into M2 differentiation, resulting in a more pronounced anti-inflammatory activity in M1 macrophages. However, PPARgamma activation does not influence M2 marker expression in resting or M1 macrophages, nor does PPARgamma agonist treatment influence the expression of M2 markers in atherosclerotic lesions, indicating that only native monocytes can be primed by PPARgamma activation to an enhanced M2 phenotype. Furthermore, PPARgamma activation significantly increases expression of the M2 marker MR in circulating peripheral blood mononuclear cells. These data demonstrate that PPARgamma activation skews human monocytes toward an anti-inflammatory M2 phenotype. IS - 2 JF - Cell Metab EP - 43 TI - PPARgamma activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties VL - 6 SP - 137 KW - artery KW - benzophenones KW - biological KW - blood KW - carotid KW - cell KW - cells KW - communication KW - cultured KW - differentiation KW - diseases KW - file-import-08-07-27 KW - foam KW - gamma KW - humans KW - inflammation KW - macrophages KW - markers KW - monocytes KW - paracrine KW - phenotype KW - ppar KW - stem KW - tyrosine AU - Bouhlel, Amine AU - Derudas, Bruno AU - Rigamonti, Elena AU - Di{è}vart, R{é}becca AU - Brozek, John AU - Haulon, St{é}phan AU - Zawadzki, Christophe AU - Jude, Brigitte AU - Torpier, G{é}rard AU - Marx, Nikolaus AU - Staels, Bart AU - Gbaguidi, Giulia PY - 2007/Aug// UR - http://dx.doi.org/10.1016/j.cmet.2007.06.010 ER -